Single cell type - CADPS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CADPS2
Gene descriptionⁱ Full gene name according to HGNC.	Calcium dependent secretion activator 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Excitatory neurons, Microglial cells, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HUVEC TERT2, Karpas-707, OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Microglial cells, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CADPS2 is part of cluster 21 Neurons & Oligodendrocytes - Neuronal signaling with confidenceⁱ 1
589 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ANO3	Anoctamin 3	0.9497	21
POU6F2	POU class 6 homeobox 2	0.9463	21
OR1J2	Olfactory receptor family 1 subfamily J member 2	0.9448	21
OR1Q1	Olfactory receptor family 1 subfamily Q member 1	0.9377	21
RALYL	RALY RNA binding protein like	0.9213	21
STXBP5L	Syntaxin binding protein 5 like	0.9069	21
OR2T8	Olfactory receptor family 2 subfamily T member 8	0.8956	21
NEUROD6	Neuronal differentiation 6	0.8831	21
CLSTN2	Calsyntenin 2	0.8736	21
CPNE4	Copine 4	0.8501	21
LDB2	LIM domain binding 2	0.8162	21
BTNL2	Butyrophilin like 2	0.8137	21
HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	0.8082	21
NAV3	Neuron navigator 3	0.8074	21
NRCAM	Neuronal cell adhesion molecule	0.8007	21

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	29.3 nTPM
Adipose tissue	31.8 nTPM
Breast	26.8 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	43.9 nTPM
Lung	43.9 nTPM

Astrocytes	85.2 nTPM
Brain	85.2 nTPM

B-cells	3.1 nTPM
Breast	21.3 nTPM
Kidney	4.8 nTPM
Liver	3.3 nTPM
Stomach	1.4 nTPM
Colon	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Dendritic cells	0.5 nTPM
Breast	1.5 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM

Endothelial cells	24.7 nTPM
Esophagus	49.2 nTPM
Testis	48.3 nTPM
Skeletal muscle	34.4 nTPM
Heart muscle	33.5 nTPM
Breast	27.2 nTPM
Prostate	25.5 nTPM
Lung	21.8 nTPM
Eye	21.0 nTPM
Ovary	19.6 nTPM
Liver	19.2 nTPM
Endometrium	17.6 nTPM
Skin	15.9 nTPM
Placenta	8.6 nTPM
Pancreas	3.9 nTPM

Fibroblasts	13.0 nTPM
Lung	35.7 nTPM
Esophagus	24.9 nTPM
Stomach	17.8 nTPM
Skeletal muscle	13.7 nTPM
Ovary	12.4 nTPM
Adipose tissue	9.9 nTPM
Breast	9.1 nTPM
Prostate	7.4 nTPM
Skin	6.1 nTPM
Heart muscle	3.3 nTPM
Placenta	2.3 nTPM

Intestinal goblet cells	13.2 nTPM
Colon	17.9 nTPM
Rectum	15.5 nTPM
Small intestine	6.4 nTPM

Macrophages	0.6 nTPM
Endometrium	2.0 nTPM
Breast	1.9 nTPM
Esophagus	1.6 nTPM
Lung	1.2 nTPM
Prostate	1.2 nTPM
Testis	1.2 nTPM
Skeletal muscle	0.4 nTPM
Ovary	0.1 nTPM
Adipose tissue	0.1 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	3.7 nTPM
Rectum	7.7 nTPM
Colon	3.3 nTPM
Small intestine	0.0 nTPM

Plasma cells	15.7 nTPM
Stomach	42.0 nTPM
Esophagus	18.4 nTPM
Adipose tissue	16.1 nTPM
Spleen	1.9 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	9.4 nTPM
Bronchus	10.1 nTPM
Lung	8.7 nTPM

Smooth muscle cells	6.2 nTPM
Endometrium	12.9 nTPM
Heart muscle	8.3 nTPM
Adipose tissue	7.9 nTPM
Breast	7.6 nTPM
Esophagus	6.2 nTPM
Prostate	6.0 nTPM
Ovary	5.6 nTPM
Skeletal muscle	5.0 nTPM
Skin	3.5 nTPM
Pancreas	2.9 nTPM
Bronchus	2.8 nTPM

T-cells	0.7 nTPM
Lung	4.5 nTPM
Endometrium	1.8 nTPM
Breast	1.8 nTPM
Stomach	0.9 nTPM
Kidney	0.7 nTPM
Skin	0.5 nTPM
Skeletal muscle	0.5 nTPM
Liver	0.4 nTPM
Spleen	0.2 nTPM
Colon	0.0 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM

Basal keratinocytes	2.2 nTPM
Skin	2.2 nTPM

Basal respiratory cells	7.3 nTPM
Bronchus	7.3 nTPM

Basal squamous epithelial cells	10.2 nTPM
Esophagus	10.2 nTPM

Cholangiocytes	11.5 nTPM
Liver	11.5 nTPM

Undifferentiated cells	8.0 nTPM
Rectum	9.8 nTPM
Small intestine	8.0 nTPM
Colon	6.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC