Single cell type - ABCB1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABCB1
Gene descriptionⁱ Full gene name according to HGNC.	ATP binding cassette subfamily B member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes CD markers Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Enterocytes - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Microglial cells, Proximal enterocytes, Distal enterocytes, Paneth cells, Cholangiocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (MAIT T-cell, NK-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CACO-2, HEK93, HEL, Hep G2, RPTEC TERT1, SH-SY5Y)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Microglial cells, Proximal enterocytes, Distal enterocytes, Paneth cells, Cholangiocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ABCB1 is part of cluster 45 Enterocytes - Digestion with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMIGD1	Transmembrane and immunoglobulin domain containing 1	0.7933	45
ABCG2	ATP binding cassette subfamily G member 2 (Junior blood group)	0.7808	45
TUBAL3	Tubulin alpha like 3	0.7662	45
SLC51B	Solute carrier family 51 subunit beta	0.7655	45
TMEM37	Transmembrane protein 37	0.7600	45
C11orf86	Chromosome 11 open reading frame 86	0.7597	45
AOC1	Amine oxidase copper containing 1	0.7494	45
RETSAT	Retinol saturase	0.7428	45
PDE9A	Phosphodiesterase 9A	0.7409	45
BTNL8	Butyrophilin like 8	0.7375	45
HHLA2	HERV-H LTR-associating 2	0.7365	53
SULT1A2	Sulfotransferase family 1A member 2	0.7218	45
GNA11	G protein subunit alpha 11	0.7215	45
BTNL3	Butyrophilin like 3	0.7168	45
CIDEC	Cell death inducing DFFA like effector c	0.7062	45

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.1 nTPM
Breast	18.9 nTPM
Adipose tissue	15.3 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	3.0 nTPM
Lung	3.0 nTPM

Astrocytes	3.9 nTPM
Brain	3.9 nTPM

B-cells	9.9 nTPM
Colon	19.2 nTPM
Stomach	18.2 nTPM
Lymph node	14.5 nTPM
PBMC	11.5 nTPM
Adipose tissue	10.5 nTPM
Kidney	9.5 nTPM
Bone marrow	6.6 nTPM
Spleen	5.5 nTPM
Liver	2.6 nTPM
Breast	1.3 nTPM

Dendritic cells	24.7 nTPM
Adipose tissue	44.8 nTPM
Breast	25.2 nTPM
PBMC	4.0 nTPM

Endothelial cells	52.9 nTPM
Eye	263.8 nTPM
Endometrium	98.4 nTPM
Testis	97.8 nTPM
Esophagus	69.4 nTPM
Prostate	50.2 nTPM
Breast	45.4 nTPM
Placenta	39.3 nTPM
Heart muscle	26.5 nTPM
Skin	20.8 nTPM
Lung	9.3 nTPM
Ovary	8.8 nTPM
Skeletal muscle	6.2 nTPM
Pancreas	3.9 nTPM
Liver	0.9 nTPM

Fibroblasts	3.7 nTPM
Stomach	13.4 nTPM
Prostate	8.1 nTPM
Esophagus	7.3 nTPM
Lung	6.7 nTPM
Skeletal muscle	3.1 nTPM
Heart muscle	1.5 nTPM
Breast	0.6 nTPM
Placenta	0.2 nTPM
Skin	0.2 nTPM
Adipose tissue	0.2 nTPM
Ovary	0.0 nTPM

Intestinal goblet cells	15.8 nTPM
Small intestine	38.8 nTPM
Colon	4.3 nTPM
Rectum	4.3 nTPM

Macrophages	1.6 nTPM
Kidney	6.1 nTPM
Prostate	4.6 nTPM
Esophagus	3.1 nTPM
Breast	3.0 nTPM
Spleen	2.1 nTPM
Endometrium	1.7 nTPM
Adipose tissue	1.5 nTPM
Testis	0.6 nTPM
Skeletal muscle	0.6 nTPM
Lung	0.4 nTPM
Ovary	0.2 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	106.2 nTPM
Colon	227.3 nTPM
Small intestine	82.6 nTPM
Rectum	8.8 nTPM

Plasma cells	4.6 nTPM
Adipose tissue	21.3 nTPM
Stomach	0.9 nTPM
Spleen	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	0.7 nTPM
Lung	1.5 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	1.3 nTPM
Breast	4.9 nTPM
Heart muscle	3.0 nTPM
Bronchus	2.9 nTPM
Endometrium	1.0 nTPM
Prostate	0.9 nTPM
Skin	0.7 nTPM
Pancreas	0.5 nTPM
Ovary	0.4 nTPM
Adipose tissue	0.4 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM

T-cells	24.5 nTPM
Endometrium	60.4 nTPM
Colon	60.3 nTPM
Stomach	49.3 nTPM
Liver	44.5 nTPM
Lung	28.8 nTPM
Breast	26.7 nTPM
Kidney	22.6 nTPM
Prostate	19.0 nTPM
Adipose tissue	18.3 nTPM
Bone marrow	16.6 nTPM
Ovary	15.6 nTPM
Skeletal muscle	12.7 nTPM
Spleen	12.3 nTPM
PBMC	11.9 nTPM
Lymph node	11.7 nTPM
Esophagus	6.6 nTPM
Skin	0.0 nTPM

Basal keratinocytes	0.8 nTPM
Skin	0.8 nTPM

Basal prostatic cells	0.1 nTPM
Prostate	0.1 nTPM

Basal squamous epithelial cells	1.2 nTPM
Esophagus	1.2 nTPM

Cholangiocytes	95.8 nTPM
Liver	95.8 nTPM

Undifferentiated cells	19.9 nTPM
Small intestine	56.2 nTPM
Colon	1.9 nTPM
Rectum	1.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC