Single cell type - LPCAT2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LPCAT2
Gene descriptionⁱ Full gene name according to HGNC.	Lysophosphatidylcholine acyltransferase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulocytes - Receptor signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Microglial cells, granulocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil, basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2, HaCaT, HL-60, HMC-1, hTERT-RPE1, WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Microglial cells, granulocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

LPCAT2 is part of cluster 60 Granulocytes - Receptor signaling with confidenceⁱ 1
79 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SIGLEC8	Sialic acid binding Ig like lectin 8	0.6178	60
RGS2	Regulator of G protein signaling 2	0.5990	60
IL1RL1	Interleukin 1 receptor like 1	0.5828	60
TPSAB1	Tryptase alpha/beta 1	0.5774	60
DUSP6	Dual specificity phosphatase 6	0.5717	60
HPGDS	Hematopoietic prostaglandin D synthase	0.5716	60
TPSB2	Tryptase beta 2	0.5680	60
RGS13	Regulator of G protein signaling 13	0.5520	60
CMA1	Chymase 1	0.5519	60
TPSD1	Tryptase delta 1	0.5513	60
MS4A2	Membrane spanning 4-domains A2	0.5490	60
AC107959.5	Novel protein	0.5475	60
MAS1L	MAS1 proto-oncogene like, G protein-coupled receptor	0.5473	60
CPA3	Carboxypeptidase A3	0.5454	60
TNFRSF10C	TNF receptor superfamily member 10c	0.5396	60

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	68.6 nTPM
Adipose tissue	80.8 nTPM
Breast	56.4 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	25.7 nTPM
Lung	25.7 nTPM

Astrocytes	2.9 nTPM
Brain	2.9 nTPM

B-cells	1.1 nTPM
Liver	2.6 nTPM
Breast	2.6 nTPM
Bone marrow	1.7 nTPM
Colon	1.6 nTPM
Lymph node	1.1 nTPM
Spleen	1.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM

Dendritic cells	3.3 nTPM
PBMC	8.0 nTPM
Breast	1.1 nTPM
Adipose tissue	0.9 nTPM

Endothelial cells	41.0 nTPM
Ovary	99.1 nTPM
Eye	80.9 nTPM
Testis	72.6 nTPM
Skin	49.3 nTPM
Esophagus	45.5 nTPM
Breast	45.3 nTPM
Skeletal muscle	40.2 nTPM
Heart muscle	35.7 nTPM
Endometrium	26.1 nTPM
Placenta	24.5 nTPM
Prostate	19.4 nTPM
Lung	18.7 nTPM
Pancreas	11.6 nTPM
Liver	5.5 nTPM

Fibroblasts	20.7 nTPM
Heart muscle	65.0 nTPM
Skeletal muscle	39.9 nTPM
Placenta	25.4 nTPM
Esophagus	22.2 nTPM
Prostate	15.6 nTPM
Adipose tissue	13.9 nTPM
Lung	13.4 nTPM
Stomach	10.4 nTPM
Skin	9.9 nTPM
Breast	8.4 nTPM
Ovary	3.4 nTPM

Intestinal goblet cells	12.2 nTPM
Rectum	16.8 nTPM
Small intestine	11.4 nTPM
Colon	8.5 nTPM

Macrophages	74.4 nTPM
Testis	173.7 nTPM
Prostate	127.2 nTPM
Breast	107.4 nTPM
Esophagus	88.1 nTPM
Adipose tissue	80.1 nTPM
Stomach	79.1 nTPM
Lung	76.2 nTPM
Bone marrow	73.7 nTPM
Endometrium	64.2 nTPM
Spleen	63.2 nTPM
Skeletal muscle	56.8 nTPM
Kidney	52.9 nTPM
Pancreas	51.0 nTPM
Ovary	22.0 nTPM
PBMC	0.0 nTPM

Paneth cells	23.0 nTPM
Rectum	35.2 nTPM
Small intestine	33.8 nTPM
Colon	0.0 nTPM

Plasma cells	1.0 nTPM
Adipose tissue	3.3 nTPM
Stomach	0.9 nTPM
Spleen	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	8.1 nTPM
Bronchus	13.4 nTPM
Lung	2.9 nTPM

Smooth muscle cells	4.2 nTPM
Heart muscle	13.3 nTPM
Prostate	9.7 nTPM
Bronchus	5.6 nTPM
Breast	4.9 nTPM
Skeletal muscle	3.1 nTPM
Pancreas	2.8 nTPM
Endometrium	2.4 nTPM
Esophagus	1.5 nTPM
Skin	1.4 nTPM
Adipose tissue	0.9 nTPM
Ovary	0.5 nTPM

T-cells	5.6 nTPM
Prostate	37.9 nTPM
Lung	22.8 nTPM
Esophagus	19.7 nTPM
Skin	3.6 nTPM
Endometrium	2.9 nTPM
PBMC	1.9 nTPM
Skeletal muscle	1.5 nTPM
Breast	1.5 nTPM
Kidney	1.4 nTPM
Colon	1.0 nTPM
Bone marrow	0.5 nTPM
Adipose tissue	0.3 nTPM
Liver	0.2 nTPM
Lymph node	0.2 nTPM
Spleen	0.2 nTPM
Ovary	0.0 nTPM
Stomach	0.0 nTPM

Basal keratinocytes	15.4 nTPM
Skin	15.4 nTPM

Basal prostatic cells	37.2 nTPM
Prostate	37.2 nTPM

Basal respiratory cells	68.3 nTPM
Bronchus	68.3 nTPM

Basal squamous epithelial cells	17.1 nTPM
Esophagus	17.1 nTPM

Undifferentiated cells	11.6 nTPM
Rectum	12.7 nTPM
Small intestine	11.1 nTPM
Colon	10.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC