Single cell type - AAMDC - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AAMDC
Gene descriptionⁱ Full gene name according to HGNC.	Adipogenesis associated Mth938 domain containing
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Theca cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CACO-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Theca cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AAMDC is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FLYWCH2	FLYWCH family member 2	0.5151	13
DIRAS3	DIRAS family GTPase 3	0.5057	52
HEBP1	Heme binding protein 1	0.5005	45
HOXD8	Homeobox D8	0.4959	66
BOD1	Biorientation of chromosomes in cell division 1	0.4944	52
EXOC3L1	Exocyst complex component 3 like 1	0.4817	14
BORCS7	BLOC-1 related complex subunit 7	0.4665	39
SCML1	Scm polycomb group protein like 1	0.4652	13
ZNF541	Zinc finger protein 541	0.4599	13
GPRASP2	G protein-coupled receptor associated sorting protein 2	0.4594	13
ADCK5	AarF domain containing kinase 5	0.4507	45
HSD3B2	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.4470	52
S100A13	S100 calcium binding protein A13	0.4467	52
HOMER3	Homer scaffold protein 3	0.4372	52
CYP17A1	Cytochrome P450 family 17 subfamily A member 1	0.4319	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	68.4 nTPM
Breast	76.6 nTPM
Adipose tissue	60.1 nTPM

Alveolar cells type 1	83.3 nTPM
Lung	83.3 nTPM

Alveolar cells type 2	25.4 nTPM
Lung	25.4 nTPM

Astrocytes	19.6 nTPM
Brain	19.6 nTPM

B-cells	10.0 nTPM
Kidney	28.5 nTPM
Breast	14.7 nTPM
Colon	12.8 nTPM
Liver	11.2 nTPM
PBMC	9.9 nTPM
Stomach	5.9 nTPM
Adipose tissue	5.0 nTPM
Lymph node	4.4 nTPM
Bone marrow	4.1 nTPM
Spleen	3.1 nTPM

Dendritic cells	11.8 nTPM
Breast	14.6 nTPM
PBMC	12.0 nTPM
Adipose tissue	8.8 nTPM

Endothelial cells	55.7 nTPM
Skin	84.5 nTPM
Liver	80.7 nTPM
Testis	75.3 nTPM
Breast	69.5 nTPM
Placenta	66.5 nTPM
Skeletal muscle	63.5 nTPM
Pancreas	54.0 nTPM
Ovary	52.3 nTPM
Prostate	47.9 nTPM
Esophagus	43.2 nTPM
Lung	40.6 nTPM
Heart muscle	35.8 nTPM
Endometrium	35.1 nTPM
Eye	30.7 nTPM

Fibroblasts	64.5 nTPM
Adipose tissue	101.2 nTPM
Lung	86.0 nTPM
Breast	73.0 nTPM
Placenta	72.5 nTPM
Skin	69.2 nTPM
Skeletal muscle	62.1 nTPM
Heart muscle	61.3 nTPM
Ovary	57.4 nTPM
Esophagus	54.6 nTPM
Prostate	38.5 nTPM
Stomach	34.1 nTPM

Intestinal goblet cells	48.7 nTPM
Small intestine	53.5 nTPM
Rectum	53.4 nTPM
Colon	39.3 nTPM

Macrophages	22.5 nTPM
Kidney	46.8 nTPM
Ovary	44.2 nTPM
Prostate	35.5 nTPM
Testis	27.8 nTPM
Breast	25.4 nTPM
Lung	23.8 nTPM
Stomach	20.5 nTPM
Endometrium	19.8 nTPM
Pancreas	17.8 nTPM
Esophagus	17.3 nTPM
Skeletal muscle	17.0 nTPM
Spleen	16.5 nTPM
Adipose tissue	15.5 nTPM
Bone marrow	10.0 nTPM
PBMC	0.0 nTPM

Paneth cells	132.2 nTPM
Colon	197.6 nTPM
Small intestine	105.1 nTPM
Rectum	94.0 nTPM

Plasma cells	10.2 nTPM
Esophagus	24.6 nTPM
Adipose tissue	12.2 nTPM
Spleen	5.3 nTPM
Bone marrow	5.0 nTPM
Stomach	3.9 nTPM

Respiratory ciliated cells	50.1 nTPM
Bronchus	52.2 nTPM
Lung	48.1 nTPM

Smooth muscle cells	65.8 nTPM
Skin	89.0 nTPM
Breast	84.2 nTPM
Prostate	80.7 nTPM
Adipose tissue	73.4 nTPM
Skeletal muscle	69.3 nTPM
Ovary	66.0 nTPM
Pancreas	62.2 nTPM
Bronchus	61.5 nTPM
Esophagus	57.4 nTPM
Heart muscle	45.0 nTPM
Endometrium	35.5 nTPM

T-cells	14.8 nTPM
Kidney	36.3 nTPM
Skin	31.8 nTPM
Prostate	23.6 nTPM
Breast	21.9 nTPM
Colon	20.9 nTPM
Skeletal muscle	18.7 nTPM
Liver	16.1 nTPM
Endometrium	15.2 nTPM
PBMC	13.8 nTPM
Adipose tissue	10.3 nTPM
Spleen	9.0 nTPM
Ovary	8.9 nTPM
Lymph node	8.2 nTPM
Stomach	7.2 nTPM
Bone marrow	5.6 nTPM
Lung	4.5 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	64.2 nTPM
Skin	64.2 nTPM

Basal prostatic cells	82.7 nTPM
Prostate	82.7 nTPM

Basal respiratory cells	51.0 nTPM
Bronchus	51.0 nTPM

Basal squamous epithelial cells	24.5 nTPM
Esophagus	24.5 nTPM

Undifferentiated cells	61.0 nTPM
Rectum	70.1 nTPM
Small intestine	64.9 nTPM
Colon	48.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC