Single cell type - EPB41L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EPB41L1
Gene descriptionⁱ Full gene name according to HGNC.	Erythrocyte membrane protein band 4.1 like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	18

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells, Inhibitory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (A549, HaCaT, OE19, SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells, Inhibitory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EPB41L1 is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 1
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TRPC6	Transient receptor potential cation channel subfamily C member 6	0.4493	8
SMTN	Smoothelin	0.4412	48
CDH6	Cadherin 6	0.4330	67
RNF152	Ring finger protein 152	0.4244	67
TGFB1I1	Transforming growth factor beta 1 induced transcript 1	0.4233	48
GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1	0.4213	48
THY1	Thy-1 cell surface antigen	0.4146	50
DACT3	Dishevelled binding antagonist of beta catenin 3	0.4140	48
ADRA1D	Adrenoceptor alpha 1D	0.4130	48
ARHGEF17	Rho guanine nucleotide exchange factor 17	0.4124	48
MCF2	MCF.2 cell line derived transforming sequence	0.4084	8
ADCY1	Adenylate cyclase 1	0.4047	9
TNPO2	Transportin 2	0.4019	9
NRIP2	Nuclear receptor interacting protein 2	0.4014	48
LRIT3	Leucine rich repeat, Ig-like and transmembrane domains 3	0.3997	9

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.5 nTPM
Breast	21.4 nTPM
Adipose tissue	7.5 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	22.1 nTPM
Lung	22.1 nTPM

Astrocytes	27.7 nTPM
Brain	27.7 nTPM

B-cells	0.4 nTPM
Liver	1.3 nTPM
Breast	1.3 nTPM
Lymph node	0.5 nTPM
Stomach	0.5 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Dendritic cells	0.8 nTPM
Breast	1.8 nTPM
Adipose tissue	0.4 nTPM
PBMC	0.0 nTPM

Endothelial cells	9.2 nTPM
Eye	25.1 nTPM
Lung	18.7 nTPM
Skeletal muscle	14.0 nTPM
Breast	13.5 nTPM
Liver	10.1 nTPM
Heart muscle	10.0 nTPM
Ovary	8.5 nTPM
Pancreas	7.7 nTPM
Testis	7.4 nTPM
Esophagus	4.2 nTPM
Skin	3.7 nTPM
Endometrium	3.3 nTPM
Prostate	1.7 nTPM
Placenta	0.6 nTPM

Fibroblasts	11.0 nTPM
Stomach	17.8 nTPM
Adipose tissue	13.7 nTPM
Breast	13.5 nTPM
Skeletal muscle	13.4 nTPM
Esophagus	13.4 nTPM
Lung	11.1 nTPM
Ovary	10.8 nTPM
Placenta	9.1 nTPM
Heart muscle	6.9 nTPM
Skin	6.8 nTPM
Prostate	4.8 nTPM

Intestinal goblet cells	6.0 nTPM
Rectum	8.5 nTPM
Small intestine	7.4 nTPM
Colon	2.2 nTPM

Macrophages	6.0 nTPM
Lung	28.4 nTPM
Esophagus	17.3 nTPM
Ovary	15.8 nTPM
Skeletal muscle	11.2 nTPM
Adipose tissue	9.6 nTPM
Breast	2.6 nTPM
Kidney	2.3 nTPM
Endometrium	1.7 nTPM
Testis	0.6 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	15.7 nTPM
Small intestine	18.8 nTPM
Rectum	18.3 nTPM
Colon	9.9 nTPM

Plasma cells	2.1 nTPM
Esophagus	6.1 nTPM
Stomach	4.2 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	21.9 nTPM
Lung	29.1 nTPM
Bronchus	14.7 nTPM

Smooth muscle cells	35.1 nTPM
Heart muscle	83.2 nTPM
Skeletal muscle	68.4 nTPM
Adipose tissue	60.5 nTPM
Ovary	45.3 nTPM
Endometrium	33.5 nTPM
Breast	32.0 nTPM
Esophagus	26.4 nTPM
Bronchus	15.0 nTPM
Skin	9.8 nTPM
Prostate	8.4 nTPM
Pancreas	3.6 nTPM

T-cells	0.8 nTPM
Kidney	6.2 nTPM
Endometrium	1.9 nTPM
Lung	1.5 nTPM
Skeletal muscle	1.5 nTPM
Skin	1.4 nTPM
Breast	0.8 nTPM
Liver	0.2 nTPM
Adipose tissue	0.2 nTPM
Stomach	0.2 nTPM
PBMC	0.1 nTPM
Colon	0.0 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	2.9 nTPM
Skin	2.9 nTPM

Basal prostatic cells	5.0 nTPM
Prostate	5.0 nTPM

Basal squamous epithelial cells	30.7 nTPM
Esophagus	30.7 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Undifferentiated cells	13.2 nTPM
Rectum	16.3 nTPM
Colon	13.4 nTPM
Small intestine	9.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC