Single cell type - KIZ - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KIZ
Gene descriptionⁱ Full gene name according to HGNC.	Kizuna centrosomal protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Oligodendrocyte precursor cells, Oligodendrocytes, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Hep G2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Oligodendrocyte precursor cells, Oligodendrocytes, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KIZ is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EFCAB11	EF-hand calcium binding domain 11	0.6435	34
PACRGL	Parkin coregulated like	0.5674	34
DXO	Decapping exoribonuclease	0.5663	34
SERP2	Stress associated endoplasmic reticulum protein family member 2	0.5536	34
CEP350	Centrosomal protein 350	0.5508	34
AMZ1	Archaelysin family metallopeptidase 1	0.5452	68
DEFB135	Defensin beta 135	0.5416	34
DYNLRB2	Dynein light chain roadblock-type 2	0.5410	34
ARID2	AT-rich interaction domain 2	0.5311	29
CEP57	Centrosomal protein 57	0.5279	34
TNKS	Tankyrase	0.5204	8
SOX6	SRY-box transcription factor 6	0.5200	68
C2orf73	Chromosome 2 open reading frame 73	0.5188	34
TP53TG3	TP53 target 3	0.5179	34
PSD3	Pleckstrin and Sec7 domain containing 3	0.5150	29

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.0 nTPM
Breast	11.2 nTPM
Adipose tissue	10.7 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	10.0 nTPM
Lung	10.0 nTPM

Astrocytes	41.1 nTPM
Brain	41.1 nTPM

B-cells	22.6 nTPM
Breast	32.1 nTPM
Stomach	30.9 nTPM
Lymph node	28.2 nTPM
Bone marrow	27.0 nTPM
PBMC	25.7 nTPM
Spleen	21.5 nTPM
Adipose tissue	19.5 nTPM
Liver	15.2 nTPM
Kidney	14.3 nTPM
Colon	11.2 nTPM

Dendritic cells	16.6 nTPM
Adipose tissue	17.2 nTPM
Breast	16.8 nTPM
PBMC	16.0 nTPM

Endothelial cells	8.7 nTPM
Eye	19.4 nTPM
Liver	16.5 nTPM
Testis	14.5 nTPM
Skeletal muscle	10.1 nTPM
Ovary	9.6 nTPM
Breast	8.0 nTPM
Pancreas	7.7 nTPM
Heart muscle	7.4 nTPM
Lung	6.2 nTPM
Prostate	5.9 nTPM
Placenta	5.7 nTPM
Esophagus	5.7 nTPM
Endometrium	4.7 nTPM
Skin	0.0 nTPM

Fibroblasts	19.4 nTPM
Heart muscle	28.1 nTPM
Ovary	25.8 nTPM
Lung	23.4 nTPM
Stomach	20.8 nTPM
Prostate	20.6 nTPM
Adipose tissue	20.6 nTPM
Breast	20.3 nTPM
Esophagus	19.3 nTPM
Skeletal muscle	18.0 nTPM
Placenta	17.0 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	9.1 nTPM
Small intestine	13.5 nTPM
Colon	7.2 nTPM
Rectum	6.8 nTPM

Macrophages	6.1 nTPM
Breast	13.0 nTPM
Ovary	12.6 nTPM
Lung	10.4 nTPM
Skeletal muscle	9.3 nTPM
Kidney	8.3 nTPM
Testis	6.9 nTPM
Adipose tissue	6.7 nTPM
Esophagus	6.3 nTPM
Bone marrow	6.2 nTPM
Endometrium	4.4 nTPM
Spleen	4.2 nTPM
Prostate	3.4 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	5.6 nTPM
Small intestine	11.3 nTPM
Rectum	5.5 nTPM
Colon	0.0 nTPM

Plasma cells	25.9 nTPM
Stomach	43.4 nTPM
Esophagus	30.7 nTPM
Spleen	29.0 nTPM
Bone marrow	13.2 nTPM
Adipose tissue	13.0 nTPM

Respiratory ciliated cells	10.2 nTPM
Lung	20.4 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	11.4 nTPM
Prostate	22.2 nTPM
Breast	18.2 nTPM
Skeletal muscle	18.0 nTPM
Ovary	13.6 nTPM
Adipose tissue	12.2 nTPM
Heart muscle	11.1 nTPM
Pancreas	10.8 nTPM
Endometrium	10.3 nTPM
Esophagus	9.3 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	17.8 nTPM
Ovary	28.9 nTPM
PBMC	28.2 nTPM
Esophagus	26.2 nTPM
Lymph node	25.9 nTPM
Breast	20.3 nTPM
Liver	19.9 nTPM
Bone marrow	19.2 nTPM
Adipose tissue	18.6 nTPM
Stomach	17.9 nTPM
Colon	17.6 nTPM
Spleen	16.3 nTPM
Lung	15.2 nTPM
Skeletal muscle	13.9 nTPM
Endometrium	13.3 nTPM
Kidney	11.6 nTPM
Prostate	9.5 nTPM
Skin	0.0 nTPM

Basal prostatic cells	9.2 nTPM
Prostate	9.2 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Collecting duct cells	18.4 nTPM
Kidney	18.4 nTPM

Cone photoreceptor cells	37.5 nTPM
Eye	37.5 nTPM

Undifferentiated cells	9.7 nTPM
Small intestine	21.7 nTPM
Rectum	5.1 nTPM
Colon	2.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC