Single cell type - MAPKAPK5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAPKAPK5
Gene descriptionⁱ Full gene name according to HGNC.	MAPK activated protein kinase 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MAPKAPK5 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CENPV	Centromere protein V	0.6017	53
ANXA13	Annexin A13	0.5880	27
PPP1R37	Protein phosphatase 1 regulatory subunit 37	0.5566	62
NUTM2A	NUT family member 2A	0.5564	53
ANKS4B	Ankyrin repeat and sterile alpha motif domain containing 4B	0.5427	45
GUCY2C	Guanylate cyclase 2C	0.5405	17
MNX1	Motor neuron and pancreas homeobox 1	0.5241	53
GPR160	G protein-coupled receptor 160	0.5212	53
MUC3A	Mucin 3A, cell surface associated	0.5193	45
HNF1A	HNF1 homeobox A	0.5106	45
LGALS4	Galectin 4	0.5065	53
SDHAF1	Succinate dehydrogenase complex assembly factor 1	0.5062	32
HPCAL1	Hippocalcin like 1	0.5046	27
SLC13A2	Solute carrier family 13 member 2	0.4997	67
SMPD3	Sphingomyelin phosphodiesterase 3	0.4978	62

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.9 nTPM
Adipose tissue	19.2 nTPM
Breast	14.6 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	23.1 nTPM
Lung	23.1 nTPM

Astrocytes	12.1 nTPM
Brain	12.1 nTPM

B-cells	22.3 nTPM
Breast	33.4 nTPM
Lymph node	28.7 nTPM
Stomach	27.3 nTPM
Spleen	23.6 nTPM
Adipose tissue	21.6 nTPM
PBMC	21.4 nTPM
Kidney	19.0 nTPM
Bone marrow	18.8 nTPM
Liver	18.2 nTPM
Colon	11.2 nTPM

Dendritic cells	32.4 nTPM
PBMC	39.8 nTPM
Breast	31.3 nTPM
Adipose tissue	26.0 nTPM

Endothelial cells	16.0 nTPM
Prostate	29.3 nTPM
Skeletal muscle	21.6 nTPM
Ovary	20.4 nTPM
Esophagus	19.2 nTPM
Heart muscle	17.4 nTPM
Placenta	17.0 nTPM
Endometrium	16.3 nTPM
Pancreas	15.5 nTPM
Testis	15.1 nTPM
Skin	14.8 nTPM
Breast	13.7 nTPM
Liver	12.8 nTPM
Eye	8.1 nTPM
Lung	3.1 nTPM

Fibroblasts	19.4 nTPM
Heart muscle	40.0 nTPM
Prostate	29.2 nTPM
Placenta	19.9 nTPM
Ovary	18.9 nTPM
Skeletal muscle	17.5 nTPM
Adipose tissue	16.4 nTPM
Stomach	16.3 nTPM
Esophagus	16.1 nTPM
Breast	15.5 nTPM
Skin	15.0 nTPM
Lung	8.9 nTPM

Intestinal goblet cells	47.3 nTPM
Rectum	57.9 nTPM
Colon	45.0 nTPM
Small intestine	39.0 nTPM

Macrophages	15.0 nTPM
Pancreas	25.5 nTPM
Testis	22.6 nTPM
Breast	22.0 nTPM
Ovary	19.4 nTPM
Esophagus	18.9 nTPM
Adipose tissue	17.3 nTPM
Lung	16.3 nTPM
Skeletal muscle	16.1 nTPM
Spleen	14.5 nTPM
Prostate	13.8 nTPM
Stomach	11.7 nTPM
Kidney	9.9 nTPM
Endometrium	9.2 nTPM
Bone marrow	7.5 nTPM
PBMC	0.0 nTPM

Paneth cells	27.4 nTPM
Rectum	41.8 nTPM
Colon	32.9 nTPM
Small intestine	7.5 nTPM

Plasma cells	21.6 nTPM
Adipose tissue	23.3 nTPM
Stomach	22.9 nTPM
Spleen	21.8 nTPM
Bone marrow	21.4 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	12.0 nTPM
Bronchus	13.7 nTPM
Lung	10.2 nTPM

Smooth muscle cells	19.8 nTPM
Pancreas	26.0 nTPM
Ovary	24.2 nTPM
Skeletal muscle	21.2 nTPM
Heart muscle	21.0 nTPM
Prostate	20.0 nTPM
Adipose tissue	19.3 nTPM
Skin	18.5 nTPM
Bronchus	17.8 nTPM
Breast	17.5 nTPM
Esophagus	17.0 nTPM
Endometrium	15.6 nTPM

T-cells	22.2 nTPM
PBMC	32.3 nTPM
Breast	29.4 nTPM
Lymph node	28.8 nTPM
Prostate	28.4 nTPM
Spleen	25.1 nTPM
Colon	24.2 nTPM
Liver	23.5 nTPM
Adipose tissue	23.5 nTPM
Skeletal muscle	22.9 nTPM
Kidney	22.6 nTPM
Bone marrow	21.9 nTPM
Stomach	20.8 nTPM
Ovary	20.1 nTPM
Skin	18.0 nTPM
Endometrium	18.0 nTPM
Lung	10.6 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	20.5 nTPM
Skin	20.5 nTPM

Basal respiratory cells	12.5 nTPM
Bronchus	12.5 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Undifferentiated cells	32.3 nTPM
Small intestine	37.0 nTPM
Rectum	35.6 nTPM
Colon	24.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC