Single cell type - OAS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OAS1
Gene descriptionⁱ Full gene name according to HGNC.	2'-5'-oligoadenylate synthetase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	22

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Distal enterocytes, Paneth cells, Hofbauer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (non-classical monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, OE19, U-266/70, U-266/84)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Distal enterocytes, Paneth cells, Hofbauer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OAS1 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CLCA4	Chloride channel accessory 4	0.8420	53
CEACAM1	CEA cell adhesion molecule 1	0.8351	53
TRIM31	Tripartite motif containing 31	0.8334	53
ARRDC4	Arrestin domain containing 4	0.8186	53
CD177	CD177 molecule	0.8016	53
AQP8	Aquaporin 8	0.7902	53
CEACAM7	CEA cell adhesion molecule 7	0.7877	53
RSAD2	Radical S-adenosyl methionine domain containing 2	0.7856	53
KRTAP13-2	Keratin associated protein 13-2	0.7782	53
TMPRSS2	Transmembrane serine protease 2	0.7767	53
MYO15B	Myosin XVB	0.7742	53
MIER3	MIER family member 3	0.7696	53
MS4A12	Membrane spanning 4-domains A12	0.7683	53
PLAC8	Placenta associated 8	0.7681	53
SIRT6	Sirtuin 6	0.7677	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	23.0 nTPM
Breast	38.3 nTPM
Adipose tissue	7.7 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	2.2 nTPM
Lung	2.2 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	21.1 nTPM
Liver	50.0 nTPM
PBMC	37.1 nTPM
Kidney	28.5 nTPM
Breast	22.8 nTPM
Bone marrow	17.2 nTPM
Spleen	15.3 nTPM
Stomach	15.0 nTPM
Lymph node	13.1 nTPM
Colon	6.4 nTPM
Adipose tissue	5.5 nTPM

Dendritic cells	31.5 nTPM
PBMC	71.8 nTPM
Breast	20.0 nTPM
Adipose tissue	2.7 nTPM

Endothelial cells	17.2 nTPM
Ovary	32.3 nTPM
Liver	30.2 nTPM
Eye	24.2 nTPM
Placenta	18.8 nTPM
Lung	18.7 nTPM
Heart muscle	17.8 nTPM
Skeletal muscle	17.8 nTPM
Prostate	17.4 nTPM
Breast	16.2 nTPM
Testis	14.5 nTPM
Esophagus	12.7 nTPM
Skin	9.3 nTPM
Pancreas	7.7 nTPM
Endometrium	2.5 nTPM

Fibroblasts	11.1 nTPM
Esophagus	23.9 nTPM
Breast	17.7 nTPM
Ovary	16.3 nTPM
Stomach	13.4 nTPM
Skeletal muscle	11.7 nTPM
Skin	8.8 nTPM
Adipose tissue	8.1 nTPM
Heart muscle	6.8 nTPM
Placenta	6.4 nTPM
Prostate	5.9 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	59.3 nTPM
Colon	82.9 nTPM
Rectum	60.0 nTPM
Small intestine	35.1 nTPM

Macrophages	52.9 nTPM
Ovary	190.3 nTPM
Testis	114.5 nTPM
Kidney	96.8 nTPM
Bone marrow	65.0 nTPM
Lung	60.5 nTPM
Skeletal muscle	48.7 nTPM
Breast	47.4 nTPM
Stomach	38.1 nTPM
Spleen	32.1 nTPM
Adipose tissue	28.5 nTPM
Esophagus	28.3 nTPM
Prostate	19.5 nTPM
Endometrium	16.4 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	127.9 nTPM
Colon	306.3 nTPM
Small intestine	48.8 nTPM
Rectum	28.5 nTPM

Plasma cells	24.1 nTPM
Bone marrow	39.5 nTPM
Spleen	38.1 nTPM
Stomach	26.1 nTPM
Esophagus	12.3 nTPM
Adipose tissue	4.5 nTPM

Respiratory ciliated cells	17.5 nTPM
Bronchus	21.8 nTPM
Lung	13.1 nTPM

Smooth muscle cells	7.5 nTPM
Bronchus	20.6 nTPM
Ovary	20.2 nTPM
Esophagus	10.9 nTPM
Prostate	9.1 nTPM
Breast	7.5 nTPM
Skeletal muscle	5.8 nTPM
Adipose tissue	3.3 nTPM
Skin	2.1 nTPM
Endometrium	1.9 nTPM
Pancreas	1.1 nTPM
Heart muscle	0.7 nTPM

T-cells	9.1 nTPM
Ovary	24.5 nTPM
Lung	18.2 nTPM
Kidney	14.4 nTPM
Breast	12.3 nTPM
Bone marrow	12.2 nTPM
PBMC	11.3 nTPM
Colon	10.9 nTPM
Liver	10.8 nTPM
Skeletal muscle	9.0 nTPM
Spleen	8.6 nTPM
Stomach	6.0 nTPM
Lymph node	5.3 nTPM
Endometrium	4.4 nTPM
Adipose tissue	4.4 nTPM
Skin	3.3 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM

Basal prostatic cells	16.6 nTPM
Prostate	16.6 nTPM

Basal respiratory cells	24.0 nTPM
Bronchus	24.0 nTPM

Cholangiocytes	14.3 nTPM
Liver	14.3 nTPM

Cytotrophoblasts	12.6 nTPM
Placenta	12.6 nTPM

Undifferentiated cells	14.6 nTPM
Colon	21.5 nTPM
Small intestine	12.9 nTPM
Rectum	9.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC