Single cell type - BIRC5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BIRC5
Gene descriptionⁱ Full gene name according to HGNC.	Baculoviral IAP repeat containing 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes, Erythroid cells, Extravillous trophoblasts, Early spermatids, Cytotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (T-reg)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes, Erythroid cells, Extravillous trophoblasts, Early spermatids, Cytotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BIRC5 is part of cluster 12 Non-specific - Cell cycle regulation with confidenceⁱ 1
294 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HMMR	Hyaluronan mediated motility receptor	0.9306	12
DLGAP5	DLG associated protein 5	0.9134	12
TYMS	Thymidylate synthetase	0.9013	12
HJURP	Holliday junction recognition protein	0.9001	12
PLK1	Polo like kinase 1	0.8995	12
KIF23	Kinesin family member 23	0.8991	12
TPX2	TPX2 microtubule nucleation factor	0.8974	12
TROAP	Trophinin associated protein	0.8954	12
CDC20	Cell division cycle 20	0.8936	12
SKA1	Spindle and kinetochore associated complex subunit 1	0.8809	12
FOXM1	Forkhead box M1	0.8757	12
GTSE1	G2 and S-phase expressed 1	0.8756	12
SKA3	Spindle and kinetochore associated complex subunit 3	0.8745	12
CCNA2	Cyclin A2	0.8735	12
SPC25	SPC25 component of NDC80 kinetochore complex	0.8721	12

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	1.2 nTPM
Breast	1.8 nTPM
Adipose tissue	0.5 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	20.0 nTPM
Lung	20.0 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	15.9 nTPM
Liver	141.5 nTPM
Colon	9.6 nTPM
Breast	2.6 nTPM
PBMC	1.4 nTPM
Lymph node	1.4 nTPM
Stomach	1.4 nTPM
Spleen	0.7 nTPM
Kidney	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM

Dendritic cells	3.3 nTPM
Adipose tissue	7.0 nTPM
Breast	2.9 nTPM
PBMC	0.0 nTPM

Endothelial cells	8.8 nTPM
Placenta	31.3 nTPM
Ovary	30.0 nTPM
Lung	24.9 nTPM
Endometrium	20.4 nTPM
Esophagus	5.2 nTPM
Breast	4.0 nTPM
Skin	3.0 nTPM
Testis	1.4 nTPM
Skeletal muscle	1.3 nTPM
Liver	0.9 nTPM
Prostate	0.6 nTPM
Heart muscle	0.5 nTPM
Eye	0.0 nTPM
Pancreas	0.0 nTPM

Erythroid cells	166.7 nTPM
Liver	261.9 nTPM
Bone marrow	71.4 nTPM

Fibroblasts	15.1 nTPM
Ovary	105.1 nTPM
Placenta	33.9 nTPM
Lung	11.1 nTPM
Heart muscle	4.2 nTPM
Skin	4.0 nTPM
Breast	3.5 nTPM
Esophagus	1.8 nTPM
Stomach	1.5 nTPM
Skeletal muscle	0.8 nTPM
Adipose tissue	0.3 nTPM
Prostate	0.2 nTPM

Intestinal goblet cells	17.1 nTPM
Small intestine	26.7 nTPM
Colon	21.5 nTPM
Rectum	3.2 nTPM

Macrophages	9.6 nTPM
Pancreas	38.3 nTPM
Endometrium	18.1 nTPM
Esophagus	17.3 nTPM
Lung	17.0 nTPM
Testis	11.1 nTPM
Prostate	10.3 nTPM
Kidney	9.1 nTPM
Breast	6.3 nTPM
Bone marrow	6.2 nTPM
Skeletal muscle	3.8 nTPM
Adipose tissue	3.0 nTPM
Ovary	2.6 nTPM
Spleen	1.0 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	2.5 nTPM
Small intestine	3.7 nTPM
Rectum	3.7 nTPM
Colon	0.0 nTPM

Plasma cells	50.2 nTPM
Spleen	150.2 nTPM
Bone marrow	90.6 nTPM
Stomach	9.5 nTPM
Adipose tissue	0.6 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	2.6 nTPM
Lung	4.4 nTPM
Bronchus	0.8 nTPM

Smooth muscle cells	15.2 nTPM
Pancreas	112.2 nTPM
Endometrium	24.9 nTPM
Ovary	23.3 nTPM
Bronchus	2.9 nTPM
Esophagus	1.5 nTPM
Prostate	1.3 nTPM
Skin	0.7 nTPM
Heart muscle	0.4 nTPM
Breast	0.2 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM

Basal keratinocytes	8.2 nTPM
Skin	8.2 nTPM

Basal respiratory cells	12.2 nTPM
Bronchus	12.2 nTPM

Basal squamous epithelial cells	2.8 nTPM
Esophagus	2.8 nTPM

Cholangiocytes	2.8 nTPM
Liver	2.8 nTPM

T-cells	10.1 nTPM
Esophagus	45.9 nTPM
Liver	30.6 nTPM
Colon	16.6 nTPM
Lung	13.6 nTPM
Endometrium	11.3 nTPM
Ovary	11.1 nTPM
Skin	8.8 nTPM
Lymph node	6.5 nTPM
Kidney	6.2 nTPM
Skeletal muscle	4.4 nTPM
Adipose tissue	4.4 nTPM
Bone marrow	3.6 nTPM
PBMC	3.5 nTPM
Spleen	3.4 nTPM
Breast	1.2 nTPM
Stomach	0.8 nTPM
Prostate	0.0 nTPM

Undifferentiated cells	38.8 nTPM
Small intestine	51.2 nTPM
Colon	41.1 nTPM
Rectum	24.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC