Single cell type - RCOR1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RCOR1
Gene descriptionⁱ Full gene name according to HGNC.	REST corepressor 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RCOR1 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MED13	Mediator complex subunit 13	0.6380	44
SPEN	Spen family transcriptional repressor	0.6093	44
BTAF1	B-TFIID TATA-box binding protein associated factor 1	0.5955	44
SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	0.5859	44
KMT2C	Lysine methyltransferase 2C	0.5824	44
EP300	E1A binding protein p300	0.5821	44
OXSR1	Oxidative stress responsive kinase 1	0.5558	41
JARID2	Jumonji and AT-rich interaction domain containing 2	0.5355	41
KDM1B	Lysine demethylase 1B	0.5338	19
DAGLB	Diacylglycerol lipase beta	0.5313	44
MAP2K3	Mitogen-activated protein kinase kinase 3	0.5298	44
TSC22D2	TSC22 domain family member 2	0.5269	44
YTHDF3	YTH N6-methyladenosine RNA binding protein 3	0.5242	44
IPMK	Inositol polyphosphate multikinase	0.5237	41
NUP153	Nucleoporin 153	0.5197	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	15.8 nTPM
Adipose tissue	16.2 nTPM
Breast	15.5 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	40.0 nTPM
Lung	40.0 nTPM

Astrocytes	32.3 nTPM
Brain	32.3 nTPM

B-cells	27.3 nTPM
Adipose tissue	53.1 nTPM
Colon	46.4 nTPM
Lymph node	39.6 nTPM
Stomach	24.5 nTPM
Bone marrow	22.9 nTPM
Spleen	22.5 nTPM
Breast	21.3 nTPM
Kidney	19.0 nTPM
Liver	12.2 nTPM
PBMC	11.5 nTPM

Dendritic cells	39.1 nTPM
Adipose tissue	65.7 nTPM
Breast	31.7 nTPM
PBMC	20.0 nTPM

Endothelial cells	15.9 nTPM
Endometrium	28.0 nTPM
Lung	21.8 nTPM
Ovary	20.8 nTPM
Esophagus	20.7 nTPM
Prostate	17.9 nTPM
Skin	17.3 nTPM
Skeletal muscle	15.8 nTPM
Breast	15.3 nTPM
Placenta	13.7 nTPM
Liver	12.8 nTPM
Eye	11.3 nTPM
Heart muscle	10.6 nTPM
Testis	8.9 nTPM
Pancreas	7.7 nTPM

Fibroblasts	20.2 nTPM
Skin	30.4 nTPM
Stomach	28.2 nTPM
Ovary	27.1 nTPM
Adipose tissue	23.5 nTPM
Skeletal muscle	23.1 nTPM
Prostate	20.9 nTPM
Lung	17.9 nTPM
Heart muscle	13.6 nTPM
Breast	13.6 nTPM
Placenta	13.2 nTPM
Esophagus	10.8 nTPM

Intestinal goblet cells	16.8 nTPM
Colon	22.8 nTPM
Rectum	18.2 nTPM
Small intestine	9.5 nTPM

Macrophages	43.6 nTPM
Adipose tissue	87.7 nTPM
Skeletal muscle	61.5 nTPM
Stomach	61.5 nTPM
Spleen	61.1 nTPM
Prostate	57.3 nTPM
Endometrium	52.7 nTPM
Bone marrow	40.0 nTPM
Esophagus	39.3 nTPM
Breast	38.8 nTPM
Ovary	38.7 nTPM
Kidney	34.8 nTPM
Lung	33.3 nTPM
Pancreas	17.8 nTPM
Testis	16.3 nTPM
PBMC	13.6 nTPM

Paneth cells	15.2 nTPM
Colon	19.7 nTPM
Rectum	14.7 nTPM
Small intestine	11.3 nTPM

Plasma cells	14.8 nTPM
Adipose tissue	43.2 nTPM
Spleen	14.9 nTPM
Stomach	11.2 nTPM
Bone marrow	5.0 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	16.3 nTPM
Bronchus	19.6 nTPM
Lung	13.1 nTPM

Smooth muscle cells	19.6 nTPM
Endometrium	37.4 nTPM
Heart muscle	31.7 nTPM
Ovary	29.5 nTPM
Prostate	23.1 nTPM
Skin	20.9 nTPM
Adipose tissue	19.0 nTPM
Breast	15.8 nTPM
Skeletal muscle	13.4 nTPM
Bronchus	11.4 nTPM
Pancreas	6.8 nTPM
Esophagus	6.2 nTPM

T-cells	26.2 nTPM
Colon	58.5 nTPM
Adipose tissue	54.6 nTPM
Endometrium	42.3 nTPM
Breast	30.5 nTPM
Skin	29.9 nTPM
Lymph node	28.6 nTPM
Esophagus	26.2 nTPM
Stomach	25.4 nTPM
Spleen	25.3 nTPM
Skeletal muscle	24.7 nTPM
Lung	21.3 nTPM
Prostate	19.0 nTPM
Ovary	17.8 nTPM
Bone marrow	12.5 nTPM
PBMC	12.3 nTPM
Kidney	9.6 nTPM
Liver	7.3 nTPM

Basal keratinocytes	57.6 nTPM
Skin	57.6 nTPM

Basal prostatic cells	27.7 nTPM
Prostate	27.7 nTPM

Basal respiratory cells	12.0 nTPM
Bronchus	12.0 nTPM

Basal squamous epithelial cells	30.7 nTPM
Esophagus	30.7 nTPM

Undifferentiated cells	22.8 nTPM
Colon	28.0 nTPM
Rectum	21.6 nTPM
Small intestine	18.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC