Single cell type - IRAK3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IRAK3
Gene descriptionⁱ Full gene name according to HGNC.	Interleukin 1 receptor associated kinase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Macrophages, Kupffer cells, Microglial cells, monocytes, Adipocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (non-classical monocyte, intermediate monocyte, classical monocyte, neutrophil, basophil, myeloid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, ASC TERT1, HEL, HL-60, NB-4, THP-1, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Macrophages, Kupffer cells, Microglial cells, monocytes, Adipocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

IRAK3 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C5AR1	Complement C5a receptor 1	0.8918	41
LIPN	Lipase family member N	0.8722	41
C5AR2	Complement component 5a receptor 2	0.8645	41
EREG	Epiregulin	0.8634	41
FPR2	Formyl peptide receptor 2	0.8501	41
IL1B	Interleukin 1 beta	0.8468	41
CYSLTR2	Cysteinyl leukotriene receptor 2	0.8199	41
LILRB2	Leukocyte immunoglobulin like receptor B2	0.8119	19
LILRA5	Leukocyte immunoglobulin like receptor A5	0.7987	19
FCAR	Fc fragment of IgA receptor	0.7968	19
NLRP3	NLR family pyrin domain containing 3	0.7965	41
NAMPT	Nicotinamide phosphoribosyltransferase	0.7751	41
CCRL2	C-C motif chemokine receptor like 2	0.7720	41
TREM1	Triggering receptor expressed on myeloid cells 1	0.7689	41
BCL2A1	BCL2 related protein A1	0.7601	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	19.4 nTPM
Lung	19.4 nTPM

Astrocytes	1.3 nTPM
Brain	1.3 nTPM

B-cells	2.3 nTPM
Adipose tissue	7.0 nTPM
Breast	4.0 nTPM
Lymph node	3.1 nTPM
Spleen	2.4 nTPM
Liver	2.0 nTPM
Colon	1.6 nTPM
PBMC	1.4 nTPM
Stomach	1.4 nTPM
Kidney	0.0 nTPM
Bone marrow	0.0 nTPM

Basal keratinocytes	1.5 nTPM
Skin	1.5 nTPM

Dendritic cells	14.8 nTPM
Adipose tissue	38.4 nTPM
PBMC	4.0 nTPM
Breast	1.8 nTPM

Endothelial cells	38.5 nTPM
Skeletal muscle	81.7 nTPM
Liver	74.3 nTPM
Heart muscle	70.3 nTPM
Eye	54.2 nTPM
Lung	46.8 nTPM
Esophagus	41.1 nTPM
Prostate	33.9 nTPM
Testis	30.8 nTPM
Breast	29.9 nTPM
Endometrium	20.8 nTPM
Placenta	19.4 nTPM
Skin	17.0 nTPM
Ovary	15.2 nTPM
Pancreas	3.9 nTPM

Fibroblasts	22.3 nTPM
Adipose tissue	38.3 nTPM
Skeletal muscle	35.1 nTPM
Prostate	32.5 nTPM
Esophagus	27.0 nTPM
Heart muscle	25.9 nTPM
Placenta	19.5 nTPM
Skin	17.5 nTPM
Lung	15.7 nTPM
Stomach	13.4 nTPM
Breast	12.5 nTPM
Ovary	7.7 nTPM

Intestinal goblet cells	1.1 nTPM
Rectum	1.9 nTPM
Colon	1.4 nTPM
Small intestine	0.0 nTPM

Macrophages	126.3 nTPM
Adipose tissue	414.3 nTPM
Stomach	307.7 nTPM
Spleen	209.4 nTPM
Skeletal muscle	199.0 nTPM
Prostate	133.0 nTPM
Bone marrow	111.2 nTPM
Ovary	102.2 nTPM
Lung	101.0 nTPM
Testis	91.2 nTPM
Kidney	68.8 nTPM
Pancreas	40.8 nTPM
Endometrium	39.6 nTPM
Esophagus	34.6 nTPM
Breast	27.9 nTPM
PBMC	13.6 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	9.1 nTPM
Adipose tissue	44.6 nTPM
Stomach	0.5 nTPM
Spleen	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	35.1 nTPM
Bronchus	63.0 nTPM
Lung	7.3 nTPM

Smooth muscle cells	10.2 nTPM
Adipose tissue	19.9 nTPM
Skeletal muscle	19.8 nTPM
Heart muscle	15.1 nTPM
Esophagus	12.4 nTPM
Bronchus	10.5 nTPM
Prostate	9.7 nTPM
Breast	7.8 nTPM
Pancreas	7.5 nTPM
Skin	3.8 nTPM
Endometrium	3.2 nTPM
Ovary	2.6 nTPM

T-cells	3.5 nTPM
Prostate	23.6 nTPM
Lung	12.2 nTPM
PBMC	3.9 nTPM
Skeletal muscle	3.8 nTPM
Endometrium	3.3 nTPM
Skin	2.8 nTPM
Liver	2.6 nTPM
Adipose tissue	2.6 nTPM
Spleen	1.7 nTPM
Breast	1.0 nTPM
Lymph node	0.9 nTPM
Bone marrow	0.7 nTPM
Stomach	0.7 nTPM
Colon	0.5 nTPM
Kidney	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Early spermatids	6.4 nTPM
Testis	6.4 nTPM

Excitatory neurons	0.4 nTPM
Brain	0.4 nTPM

Exocrine glandular cells	1.2 nTPM
Pancreas	1.2 nTPM

Undifferentiated cells	0.7 nTPM
Colon	1.7 nTPM
Rectum	0.3 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC