Single cell type - GLG1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GLG1
Gene descriptionⁱ Full gene name according to HGNC.	Golgi glycoprotein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GLG1 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LRIG2	Leucine rich repeats and immunoglobulin like domains 2	0.5468	52
ABCA8	ATP binding cassette subfamily A member 8	0.5121	50
MTX3	Metaxin 3	0.4801	52
ATP8B2	ATPase phospholipid transporting 8B2	0.4764	36
LDLRAD2	Low density lipoprotein receptor class A domain containing 2	0.4749	40
CTSO	Cathepsin O	0.4685	50
PTPRA	Protein tyrosine phosphatase receptor type A	0.4630	50
TRIM56	Tripartite motif containing 56	0.4614	52
CLCC1	Chloride channel CLIC like 1	0.4532	47
EVC2	EvC ciliary complex subunit 2	0.4529	50
IGF2R	Insulin like growth factor 2 receptor	0.4518	65
COX18	Cytochrome c oxidase assembly factor COX18	0.4482	52
MFSD8	Major facilitator superfamily domain containing 8	0.4424	52
TXNDC15	Thioredoxin domain containing 15	0.4388	55
ABCA6	ATP binding cassette subfamily A member 6	0.4370	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	52.8 nTPM
Adipose tissue	62.2 nTPM
Breast	43.5 nTPM

Alveolar cells type 1	64.1 nTPM
Lung	64.1 nTPM

Alveolar cells type 2	50.7 nTPM
Lung	50.7 nTPM

Astrocytes	114.3 nTPM
Brain	114.3 nTPM

B-cells	46.4 nTPM
Bone marrow	66.2 nTPM
Stomach	65.9 nTPM
Liver	64.5 nTPM
Adipose tissue	55.7 nTPM
Lymph node	51.8 nTPM
PBMC	42.8 nTPM
Spleen	42.2 nTPM
Breast	40.2 nTPM
Kidney	28.5 nTPM
Colon	6.4 nTPM

Dendritic cells	75.6 nTPM
Adipose tissue	90.0 nTPM
PBMC	87.6 nTPM
Breast	49.2 nTPM

Endothelial cells	62.0 nTPM
Liver	123.8 nTPM
Heart muscle	87.1 nTPM
Eye	69.6 nTPM
Endometrium	69.6 nTPM
Ovary	68.0 nTPM
Skeletal muscle	67.3 nTPM
Placenta	66.0 nTPM
Lung	65.5 nTPM
Esophagus	52.8 nTPM
Testis	47.5 nTPM
Breast	45.6 nTPM
Pancreas	42.5 nTPM
Skin	35.0 nTPM
Prostate	27.2 nTPM

Fibroblasts	101.4 nTPM
Adipose tissue	148.2 nTPM
Esophagus	146.1 nTPM
Heart muscle	131.4 nTPM
Skeletal muscle	125.8 nTPM
Stomach	117.3 nTPM
Breast	107.1 nTPM
Ovary	91.0 nTPM
Placenta	74.5 nTPM
Skin	66.6 nTPM
Lung	58.1 nTPM
Prostate	49.8 nTPM

Intestinal goblet cells	31.9 nTPM
Rectum	47.4 nTPM
Small intestine	41.1 nTPM
Colon	7.2 nTPM

Macrophages	44.4 nTPM
Stomach	70.3 nTPM
Skeletal muscle	64.5 nTPM
Ovary	61.0 nTPM
Lung	59.9 nTPM
Adipose tissue	57.8 nTPM
Spleen	51.8 nTPM
Bone marrow	48.7 nTPM
Pancreas	43.4 nTPM
Endometrium	42.0 nTPM
Testis	40.1 nTPM
Kidney	35.6 nTPM
Esophagus	34.6 nTPM
Breast	29.0 nTPM
Prostate	27.5 nTPM
PBMC	0.0 nTPM

Paneth cells	28.8 nTPM
Rectum	53.2 nTPM
Small intestine	30.0 nTPM
Colon	3.3 nTPM

Plasma cells	100.2 nTPM
Stomach	127.7 nTPM
Adipose tissue	103.8 nTPM
Esophagus	98.5 nTPM
Bone marrow	87.4 nTPM
Spleen	83.5 nTPM

Respiratory ciliated cells	44.3 nTPM
Lung	58.3 nTPM
Bronchus	30.3 nTPM

Smooth muscle cells	59.9 nTPM
Skeletal muscle	90.1 nTPM
Adipose tissue	88.7 nTPM
Endometrium	74.4 nTPM
Esophagus	72.9 nTPM
Ovary	62.7 nTPM
Heart muscle	57.8 nTPM
Breast	55.7 nTPM
Prostate	49.1 nTPM
Pancreas	47.8 nTPM
Bronchus	31.1 nTPM
Skin	28.2 nTPM

T-cells	72.4 nTPM
Skeletal muscle	122.7 nTPM
PBMC	113.7 nTPM
Bone marrow	90.8 nTPM
Adipose tissue	85.9 nTPM
Skin	82.0 nTPM
Lymph node	80.1 nTPM
Ovary	75.7 nTPM
Liver	75.6 nTPM
Spleen	72.3 nTPM
Stomach	72.1 nTPM
Esophagus	72.0 nTPM
Lung	62.3 nTPM
Kidney	58.2 nTPM
Endometrium	56.3 nTPM
Prostate	52.1 nTPM
Breast	46.9 nTPM
Colon	11.9 nTPM

Basal keratinocytes	27.1 nTPM
Skin	27.1 nTPM

Basal respiratory cells	33.0 nTPM
Bronchus	33.0 nTPM

Basal squamous epithelial cells	55.8 nTPM
Esophagus	55.8 nTPM

Cholangiocytes	77.2 nTPM
Liver	77.2 nTPM

Undifferentiated cells	32.9 nTPM
Rectum	49.7 nTPM
Small intestine	37.8 nTPM
Colon	11.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC