Single cell type - DPYSL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DPYSL2
Gene descriptionⁱ Full gene name according to HGNC.	Dihydropyrimidinase like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Adipocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (intermediate monocyte, myeloid DC, classical monocyte, non-classical monocyte, plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Adipocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DPYSL2 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SPOP	Speckle type BTB/POZ protein	0.6105	65
TACC1	Transforming acidic coiled-coil containing protein 1	0.5607	14
GALNT15	Polypeptide N-acetylgalactosaminyltransferase 15	0.5493	50
TCF4	Transcription factor 4	0.5280	14
ZDHHC17	Zinc finger DHHC-type palmitoyltransferase 17	0.5226	65
PDE2A	Phosphodiesterase 2A	0.5049	14
NRN1	Neuritin 1	0.4999	14
ITM2A	Integral membrane protein 2A	0.4966	14
SASH1	SAM and SH3 domain containing 1	0.4960	68
CD34	CD34 molecule	0.4893	14
KLF7	Kruppel like factor 7	0.4860	41
CLIC2	Chloride intracellular channel 2	0.4816	41
PTEN	Phosphatase and tensin homolog	0.4815	48
C5orf58	Chromosome 5 open reading frame 58	0.4732	50
PPDPFL	Pancreatic progenitor cell differentiation and proliferation factor like	0.4721	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	131.4 nTPM
Lung	131.4 nTPM

Alveolar cells type 2	71.7 nTPM
Lung	71.7 nTPM

Astrocytes	193.9 nTPM
Brain	193.9 nTPM

B-cells	11.5 nTPM
Adipose tissue	27.0 nTPM
Colon	17.6 nTPM
Liver	16.4 nTPM
Breast	13.4 nTPM
PBMC	11.5 nTPM
Stomach	9.6 nTPM
Bone marrow	8.1 nTPM
Lymph node	5.9 nTPM
Spleen	5.2 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	40.4 nTPM
Skin	40.4 nTPM

Adipocytes	362.9 nTPM
Adipose tissue	495.1 nTPM
Breast	230.6 nTPM

Dendritic cells	64.8 nTPM
PBMC	143.4 nTPM
Adipose tissue	33.7 nTPM
Breast	17.1 nTPM

Endothelial cells	154.6 nTPM
Liver	338.4 nTPM
Breast	267.9 nTPM
Heart muscle	227.3 nTPM
Ovary	200.4 nTPM
Skeletal muscle	166.8 nTPM
Eye	150.5 nTPM
Testis	146.7 nTPM
Skin	140.7 nTPM
Esophagus	118.6 nTPM
Endometrium	106.0 nTPM
Lung	93.6 nTPM
Placenta	77.3 nTPM
Pancreas	65.6 nTPM
Prostate	64.8 nTPM

Fibroblasts	144.9 nTPM
Adipose tissue	362.6 nTPM
Heart muscle	342.3 nTPM
Skin	222.7 nTPM
Skeletal muscle	146.0 nTPM
Esophagus	131.6 nTPM
Breast	120.4 nTPM
Stomach	78.7 nTPM
Lung	64.8 nTPM
Ovary	46.7 nTPM
Placenta	45.4 nTPM
Prostate	32.3 nTPM

Intestinal goblet cells	87.0 nTPM
Small intestine	133.8 nTPM
Rectum	72.3 nTPM
Colon	55.0 nTPM

Macrophages	111.1 nTPM
Adipose tissue	281.7 nTPM
Spleen	169.0 nTPM
Testis	150.5 nTPM
Esophagus	148.0 nTPM
Endometrium	137.7 nTPM
Skeletal muscle	112.9 nTPM
Kidney	108.1 nTPM
Ovary	107.6 nTPM
Bone marrow	106.2 nTPM
Breast	102.0 nTPM
Lung	87.8 nTPM
Stomach	76.2 nTPM
Prostate	50.4 nTPM
Pancreas	28.0 nTPM
PBMC	0.0 nTPM

Paneth cells	6.2 nTPM
Small intestine	11.3 nTPM
Rectum	4.0 nTPM
Colon	3.3 nTPM

Plasma cells	6.5 nTPM
Adipose tissue	13.0 nTPM
Esophagus	12.3 nTPM
Stomach	3.3 nTPM
Spleen	2.3 nTPM
Bone marrow	1.7 nTPM

Respiratory ciliated cells	10.5 nTPM
Lung	19.0 nTPM
Bronchus	2.0 nTPM

Smooth muscle cells	110.6 nTPM
Adipose tissue	307.0 nTPM
Skeletal muscle	209.9 nTPM
Heart muscle	192.1 nTPM
Skin	98.0 nTPM
Esophagus	91.5 nTPM
Breast	85.2 nTPM
Endometrium	72.9 nTPM
Ovary	50.7 nTPM
Prostate	45.4 nTPM
Bronchus	38.2 nTPM
Pancreas	25.9 nTPM

Cholangiocytes	84.4 nTPM
Liver	84.4 nTPM

Collecting duct cells	22.0 nTPM
Kidney	22.0 nTPM

Cone photoreceptor cells	31.3 nTPM
Eye	31.3 nTPM

Cytotrophoblasts	15.1 nTPM
Placenta	15.1 nTPM

T-cells	14.8 nTPM
Adipose tissue	31.0 nTPM
Skin	29.5 nTPM
Endometrium	29.3 nTPM
Lung	27.4 nTPM
Skeletal muscle	24.1 nTPM
Esophagus	19.7 nTPM
PBMC	17.3 nTPM
Breast	16.3 nTPM
Liver	13.0 nTPM
Colon	9.5 nTPM
Kidney	8.9 nTPM
Ovary	6.7 nTPM
Bone marrow	6.6 nTPM
Spleen	6.6 nTPM
Stomach	4.1 nTPM
Lymph node	2.5 nTPM
Prostate	0.0 nTPM

Undifferentiated cells	12.1 nTPM
Small intestine	26.3 nTPM
Rectum	5.2 nTPM
Colon	4.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC