Single cell type - COMT - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COMT
Gene descriptionⁱ Full gene name according to HGNC.	Catechol-O-methyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

COMT is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 1
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ATP6V1B1	ATPase H+ transporting V1 subunit B1	0.8142	47
TRBV20OR9-2	T cell receptor beta variable 20/OR9-2 (non-functional)	0.8130	47
GPR143	G protein-coupled receptor 143	0.8061	47
SMIM43	Small integral membrane protein 43	0.8041	47
SOX14	SRY-box transcription factor 14	0.7947	47
PAGE4	PAGE family member 4	0.7863	47
GSDME	Gasdermin E	0.7812	47
SMAGP	Small cell adhesion glycoprotein	0.7695	47
MBNL3	Muscleblind like splicing regulator 3	0.7678	47
ZFYVE19	Zinc finger FYVE-type containing 19	0.7668	47
PAK6	P21 (RAC1) activated kinase 6	0.7662	47
RMI2	RecQ mediated genome instability 2	0.7653	47
IFI6	Interferon alpha inducible protein 6	0.7632	47
MYORG	Myogenesis regulating glycosidase (putative)	0.7614	47
LARGE2	LARGE xylosyl- and glucuronyltransferase 2	0.7605	47

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	99.1 nTPM
Breast	118.5 nTPM
Adipose tissue	79.8 nTPM

Alveolar cells type 1	125.0 nTPM
Lung	125.0 nTPM

Alveolar cells type 2	88.1 nTPM
Lung	88.1 nTPM

Astrocytes	22.9 nTPM
Brain	22.9 nTPM

B-cells	33.1 nTPM
Liver	59.5 nTPM
Kidney	52.4 nTPM
Breast	45.4 nTPM
Spleen	38.4 nTPM
Colon	36.7 nTPM
PBMC	27.1 nTPM
Lymph node	24.3 nTPM
Stomach	21.4 nTPM
Bone marrow	15.5 nTPM
Adipose tissue	10.5 nTPM

Basal squamous epithelial cells	188.4 nTPM
Esophagus	188.4 nTPM

Dendritic cells	80.1 nTPM
PBMC	135.5 nTPM
Breast	73.3 nTPM
Adipose tissue	31.5 nTPM

Endothelial cells	86.7 nTPM
Placenta	172.8 nTPM
Ovary	141.7 nTPM
Breast	120.9 nTPM
Testis	101.3 nTPM
Eye	92.2 nTPM
Pancreas	88.8 nTPM
Skin	80.6 nTPM
Endometrium	72.9 nTPM
Prostate	70.1 nTPM
Skeletal muscle	66.6 nTPM
Liver	63.2 nTPM
Esophagus	61.8 nTPM
Lung	46.8 nTPM
Heart muscle	33.8 nTPM

Fibroblasts	103.1 nTPM
Placenta	213.4 nTPM
Adipose tissue	184.6 nTPM
Skin	118.3 nTPM
Skeletal muscle	96.3 nTPM
Prostate	95.2 nTPM
Breast	89.0 nTPM
Stomach	86.1 nTPM
Ovary	80.6 nTPM
Esophagus	79.5 nTPM
Heart muscle	60.3 nTPM
Lung	31.3 nTPM

Intestinal goblet cells	97.7 nTPM
Small intestine	107.8 nTPM
Colon	99.3 nTPM
Rectum	85.9 nTPM

Macrophages	137.0 nTPM
Pancreas	285.9 nTPM
Ovary	214.2 nTPM
Testis	180.1 nTPM
Kidney	158.8 nTPM
Lung	150.9 nTPM
Esophagus	144.8 nTPM
Breast	135.2 nTPM
Prostate	129.6 nTPM
Adipose tissue	126.1 nTPM
Skeletal muscle	114.8 nTPM
Endometrium	113.5 nTPM
Bone marrow	100.0 nTPM
Spleen	94.3 nTPM
Stomach	93.7 nTPM
PBMC	13.6 nTPM

Paneth cells	108.8 nTPM
Small intestine	138.9 nTPM
Rectum	121.6 nTPM
Colon	65.8 nTPM

Plasma cells	45.5 nTPM
Stomach	55.0 nTPM
Spleen	53.9 nTPM
Esophagus	49.4 nTPM
Bone marrow	44.5 nTPM
Adipose tissue	24.5 nTPM

Respiratory ciliated cells	135.8 nTPM
Bronchus	175.3 nTPM
Lung	96.2 nTPM

Smooth muscle cells	113.1 nTPM
Pancreas	245.5 nTPM
Ovary	180.6 nTPM
Breast	116.7 nTPM
Adipose tissue	105.7 nTPM
Prostate	102.9 nTPM
Esophagus	99.2 nTPM
Skeletal muscle	94.8 nTPM
Bronchus	90.2 nTPM
Skin	83.3 nTPM
Heart muscle	63.5 nTPM
Endometrium	61.9 nTPM

Cholangiocytes	104.4 nTPM
Liver	104.4 nTPM

Collecting duct cells	152.6 nTPM
Kidney	152.6 nTPM

Cone photoreceptor cells	10.4 nTPM
Eye	10.4 nTPM

Distal enterocytes	53.0 nTPM
Colon	77.6 nTPM
Rectum	28.4 nTPM

T-cells	41.8 nTPM
Liver	64.0 nTPM
Breast	56.6 nTPM
Ovary	55.6 nTPM
Esophagus	52.4 nTPM
Kidney	50.0 nTPM
Stomach	43.7 nTPM
Skeletal muscle	41.5 nTPM
Skin	40.6 nTPM
Spleen	39.3 nTPM
PBMC	39.0 nTPM
Bone marrow	38.6 nTPM
Lung	36.5 nTPM
Lymph node	35.5 nTPM
Prostate	33.1 nTPM
Endometrium	32.8 nTPM
Colon	30.9 nTPM
Adipose tissue	19.9 nTPM

Undifferentiated cells	122.3 nTPM
Small intestine	145.4 nTPM
Rectum	111.7 nTPM
Colon	109.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC