Single cell type - NUBP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUBP2
Gene descriptionⁱ Full gene name according to HGNC.	Nucleotide binding protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NUBP2 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BABAM1	BRISC and BRCA1 A complex member 1	0.6111	47
NUDCD2	NudC domain containing 2	0.5539	39
TRIAP1	TP53 regulated inhibitor of apoptosis 1	0.5340	47
ERH	ERH mRNA splicing and mitosis factor	0.5142	39
SLC35C2	Solute carrier family 35 member C2	0.5104	47
ARMC6	Armadillo repeat containing 6	0.5045	2
R3HCC1	R3H domain and coiled-coil containing 1	0.4957	46
NSMCE4A	NSE4 homolog A, SMC5-SMC6 complex component	0.4795	39
TMEM187	Transmembrane protein 187	0.4784	39
TMEM223	Transmembrane protein 223	0.4673	39
PUSL1	Pseudouridine synthase like 1	0.4666	39
PCNA	Proliferating cell nuclear antigen	0.4647	12
RNF26	Ring finger protein 26	0.4615	12
SDHAF2	Succinate dehydrogenase complex assembly factor 2	0.4609	39
PYURF	PIGY upstream reading frame	0.4572	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	41.0 nTPM
Breast	55.6 nTPM
Adipose tissue	26.5 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	30.9 nTPM
Lung	30.9 nTPM

Astrocytes	9.4 nTPM
Brain	9.4 nTPM

B-cells	38.4 nTPM
Liver	73.8 nTPM
Kidney	66.6 nTPM
PBMC	42.8 nTPM
Spleen	37.7 nTPM
Colon	30.3 nTPM
Stomach	30.0 nTPM
Bone marrow	29.4 nTPM
Breast	28.1 nTPM
Lymph node	22.9 nTPM
Adipose tissue	22.1 nTPM

Dendritic cells	55.5 nTPM
PBMC	75.7 nTPM
Breast	52.8 nTPM
Adipose tissue	38.0 nTPM

Endothelial cells	35.1 nTPM
Pancreas	57.9 nTPM
Placenta	54.6 nTPM
Breast	51.4 nTPM
Ovary	47.1 nTPM
Skin	38.8 nTPM
Liver	33.9 nTPM
Heart muscle	32.5 nTPM
Testis	30.2 nTPM
Prostate	29.4 nTPM
Endometrium	28.5 nTPM
Esophagus	28.1 nTPM
Skeletal muscle	27.5 nTPM
Eye	22.7 nTPM
Lung	9.3 nTPM

Fibroblasts	38.0 nTPM
Placenta	68.2 nTPM
Ovary	62.8 nTPM
Breast	49.9 nTPM
Skin	43.7 nTPM
Adipose tissue	35.2 nTPM
Esophagus	29.1 nTPM
Skeletal muscle	28.2 nTPM
Stomach	28.2 nTPM
Heart muscle	25.5 nTPM
Prostate	25.1 nTPM
Lung	22.4 nTPM

Intestinal goblet cells	51.7 nTPM
Colon	63.7 nTPM
Small intestine	49.1 nTPM
Rectum	42.3 nTPM

Macrophages	27.9 nTPM
Kidney	45.3 nTPM
Breast	44.5 nTPM
Pancreas	35.7 nTPM
Ovary	32.2 nTPM
Skeletal muscle	28.8 nTPM
Lung	28.3 nTPM
Endometrium	27.7 nTPM
Bone marrow	27.5 nTPM
Stomach	26.4 nTPM
Testis	25.5 nTPM
Prostate	25.3 nTPM
Spleen	24.9 nTPM
Adipose tissue	24.8 nTPM
Esophagus	22.0 nTPM
PBMC	0.0 nTPM

Paneth cells	30.4 nTPM
Rectum	37.8 nTPM
Small intestine	33.8 nTPM
Colon	19.7 nTPM

Plasma cells	38.0 nTPM
Spleen	57.1 nTPM
Stomach	42.2 nTPM
Bone marrow	41.2 nTPM
Adipose tissue	31.0 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	22.2 nTPM
Bronchus	29.8 nTPM
Lung	14.6 nTPM

Smooth muscle cells	43.3 nTPM
Pancreas	79.1 nTPM
Breast	59.7 nTPM
Ovary	54.3 nTPM
Heart muscle	47.1 nTPM
Skin	45.7 nTPM
Adipose tissue	36.3 nTPM
Skeletal muscle	36.0 nTPM
Esophagus	32.5 nTPM
Endometrium	31.4 nTPM
Prostate	31.2 nTPM
Bronchus	22.5 nTPM

T-cells	42.0 nTPM
Ovary	60.1 nTPM
Liver	59.9 nTPM
Kidney	58.2 nTPM
Skin	54.4 nTPM
PBMC	54.0 nTPM
Breast	50.4 nTPM
Colon	41.3 nTPM
Lung	38.0 nTPM
Prostate	37.9 nTPM
Stomach	37.8 nTPM
Bone marrow	36.9 nTPM
Adipose tissue	36.1 nTPM
Spleen	36.1 nTPM
Lymph node	31.6 nTPM
Skeletal muscle	30.1 nTPM
Esophagus	26.2 nTPM
Endometrium	24.6 nTPM

Basal keratinocytes	35.8 nTPM
Skin	35.8 nTPM

Basal prostatic cells	39.4 nTPM
Prostate	39.4 nTPM

Basal respiratory cells	75.8 nTPM
Bronchus	75.8 nTPM

Basal squamous epithelial cells	24.5 nTPM
Esophagus	24.5 nTPM

Undifferentiated cells	58.2 nTPM
Small intestine	67.8 nTPM
Colon	54.7 nTPM
Rectum	52.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC