Single cell type - SMIM24 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SMIM24
Gene descriptionⁱ Full gene name according to HGNC.	Small integral membrane protein 24
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Proximal enterocytes, Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (NK-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CACO-2, HEL, Hep G2, MOLT-4, OE19, REH, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Proximal enterocytes, Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SMIM24 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FAM151A	Family with sequence similarity 151 member A	0.9562	67
SLC34A3	Solute carrier family 34 member 3	0.9418	67
KHK	Ketohexokinase	0.9349	67
ALDOB	Aldolase, fructose-bisphosphate B	0.9314	67
SLC5A12	Solute carrier family 5 member 12	0.9169	67
ERICH4	Glutamate rich 4	0.9034	67
NR1H4	Nuclear receptor subfamily 1 group H member 4	0.8966	45
ENPP7	Ectonucleotide pyrophosphatase/phosphodiesterase 7	0.8821	45
DHDH	Dihydrodiol dehydrogenase	0.8813	67
SLC23A3	Solute carrier family 23 member 3	0.8640	45
SLC28A1	Solute carrier family 28 member 1	0.8521	67
DPEP1	Dipeptidase 1	0.8335	45
SLC13A2	Solute carrier family 13 member 2	0.8315	67
AKR7A3	Aldo-keto reductase family 7 member A3	0.8310	67
ENPEP	Glutamyl aminopeptidase	0.8225	45

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	0.1 nTPM
Breast	0.1 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	6.6 nTPM
Kidney	47.6 nTPM
PBMC	9.9 nTPM
Stomach	3.7 nTPM
Liver	1.7 nTPM
Colon	1.6 nTPM
Breast	1.3 nTPM
Lymph node	0.5 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Dendritic cells	0.5 nTPM
Adipose tissue	1.5 nTPM
PBMC	0.0 nTPM
Breast	0.0 nTPM

Endothelial cells	0.3 nTPM
Liver	1.8 nTPM
Eye	0.8 nTPM
Endometrium	0.5 nTPM
Heart muscle	0.2 nTPM
Breast	0.2 nTPM
Skeletal muscle	0.1 nTPM
Ovary	0.1 nTPM
Lung	0.0 nTPM
Placenta	0.0 nTPM
Prostate	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM

Enteroendocrine cells	139.0 nTPM
Colon	142.1 nTPM
Rectum	135.9 nTPM

Fibroblasts	0.3 nTPM
Placenta	1.5 nTPM
Lung	1.2 nTPM
Heart muscle	0.1 nTPM
Skeletal muscle	0.1 nTPM
Breast	0.1 nTPM
Prostate	0.0 nTPM
Skin	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	136.6 nTPM
Small intestine	359.5 nTPM
Rectum	31.1 nTPM
Colon	19.3 nTPM

Macrophages	11.6 nTPM
Kidney	165.7 nTPM
Breast	4.0 nTPM
Prostate	2.2 nTPM
Skeletal muscle	0.6 nTPM
Lung	0.4 nTPM
Endometrium	0.4 nTPM
Ovary	0.2 nTPM
Adipose tissue	0.1 nTPM
PBMC	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	178.9 nTPM
Small intestine	458.0 nTPM
Colon	59.3 nTPM
Rectum	19.3 nTPM

Plasma cells	1.7 nTPM
Adipose tissue	7.0 nTPM
Stomach	1.0 nTPM
Spleen	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	0.0 nTPM
Lung	0.0 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	0.3 nTPM
Pancreas	2.5 nTPM
Endometrium	0.3 nTPM
Ovary	0.3 nTPM
Breast	0.2 nTPM
Heart muscle	0.1 nTPM
Prostate	0.0 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Cholangiocytes	188.8 nTPM
Liver	188.8 nTPM

Collecting duct cells	58.8 nTPM
Kidney	58.8 nTPM

Cone photoreceptor cells	27.1 nTPM
Eye	27.1 nTPM

Distal enterocytes	35.1 nTPM
Colon	52.8 nTPM
Rectum	17.4 nTPM

T-cells	7.4 nTPM
Kidney	103.4 nTPM
Liver	10.6 nTPM
Endometrium	3.3 nTPM
Ovary	2.2 nTPM
Stomach	2.2 nTPM
Bone marrow	0.9 nTPM
Spleen	0.8 nTPM
PBMC	0.7 nTPM
Breast	0.5 nTPM
Lymph node	0.3 nTPM
Adipose tissue	0.2 nTPM
Colon	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	141.3 nTPM
Small intestine	344.0 nTPM
Rectum	44.2 nTPM
Colon	35.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC