Single cell type - ABL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABL1
Gene descriptionⁱ Full gene name according to HGNC.	ABL proto-oncogene 1, non-receptor tyrosine kinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ABL1 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GFPT2	Glutamine-fructose-6-phosphate transaminase 2	0.5863	50
COL16A1	Collagen type XVI alpha 1 chain	0.5600	50
COL12A1	Collagen type XII alpha 1 chain	0.5589	50
FBN1	Fibrillin 1	0.5581	50
MEDAG	Mesenteric estrogen dependent adipogenesis	0.5574	50
COL6A3	Collagen type VI alpha 3 chain	0.5531	50
PKD2	Polycystin 2, transient receptor potential cation channel	0.5444	8
SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.5429	50
ADGRG2	Adhesion G protein-coupled receptor G2	0.5415	50
COL6A2	Collagen type VI alpha 2 chain	0.5384	33
SH3PXD2B	SH3 and PX domains 2B	0.5356	50
ECM2	Extracellular matrix protein 2	0.5316	50
ELN	Elastin	0.5300	50
FSTL1	Follistatin like 1	0.5294	50
FNDC1	Fibronectin type III domain containing 1	0.5282	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.2 nTPM
Adipose tissue	20.4 nTPM
Breast	11.9 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	13.6 nTPM
Lung	13.6 nTPM

Astrocytes	54.9 nTPM
Brain	54.9 nTPM

B-cells	4.7 nTPM
PBMC	8.5 nTPM
Colon	8.0 nTPM
Adipose tissue	5.5 nTPM
Bone marrow	4.9 nTPM
Kidney	4.8 nTPM
Breast	4.0 nTPM
Stomach	3.7 nTPM
Lymph node	3.5 nTPM
Liver	3.3 nTPM
Spleen	1.0 nTPM

Dendritic cells	12.1 nTPM
Adipose tissue	22.2 nTPM
Breast	10.2 nTPM
PBMC	4.0 nTPM

Endothelial cells	18.1 nTPM
Pancreas	34.7 nTPM
Ovary	29.9 nTPM
Endometrium	28.8 nTPM
Lung	24.9 nTPM
Prostate	18.9 nTPM
Skin	15.7 nTPM
Liver	15.6 nTPM
Eye	15.4 nTPM
Placenta	14.8 nTPM
Skeletal muscle	12.6 nTPM
Testis	12.5 nTPM
Heart muscle	11.5 nTPM
Breast	10.9 nTPM
Esophagus	7.3 nTPM

Fibroblasts	36.7 nTPM
Adipose tissue	65.2 nTPM
Skeletal muscle	64.2 nTPM
Prostate	56.4 nTPM
Skin	51.5 nTPM
Breast	32.4 nTPM
Esophagus	27.7 nTPM
Placenta	26.8 nTPM
Heart muscle	24.9 nTPM
Stomach	23.7 nTPM
Ovary	23.2 nTPM
Lung	7.8 nTPM

Intestinal goblet cells	17.5 nTPM
Rectum	20.3 nTPM
Colon	17.2 nTPM
Small intestine	15.0 nTPM

Macrophages	10.2 nTPM
Ovary	24.3 nTPM
Adipose tissue	21.0 nTPM
Pancreas	15.3 nTPM
Skeletal muscle	14.0 nTPM
PBMC	13.6 nTPM
Endometrium	12.7 nTPM
Bone marrow	11.3 nTPM
Prostate	8.1 nTPM
Breast	7.8 nTPM
Spleen	7.2 nTPM
Lung	5.5 nTPM
Testis	5.2 nTPM
Kidney	4.6 nTPM
Stomach	2.9 nTPM
Esophagus	0.0 nTPM

Paneth cells	18.3 nTPM
Small intestine	22.5 nTPM
Rectum	22.4 nTPM
Colon	9.9 nTPM

Plasma cells	5.6 nTPM
Adipose tissue	19.4 nTPM
Stomach	3.4 nTPM
Bone marrow	3.3 nTPM
Spleen	1.9 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	7.8 nTPM
Bronchus	9.8 nTPM
Lung	5.8 nTPM

Smooth muscle cells	19.8 nTPM
Endometrium	27.9 nTPM
Ovary	25.9 nTPM
Prostate	25.6 nTPM
Adipose tissue	25.1 nTPM
Skin	24.7 nTPM
Skeletal muscle	23.6 nTPM
Heart muscle	23.1 nTPM
Pancreas	15.7 nTPM
Breast	14.6 nTPM
Bronchus	7.5 nTPM
Esophagus	4.6 nTPM

T-cells	7.9 nTPM
Endometrium	15.7 nTPM
Skin	12.4 nTPM
Breast	11.5 nTPM
Liver	11.2 nTPM
Skeletal muscle	11.0 nTPM
Adipose tissue	10.6 nTPM
Prostate	9.5 nTPM
Ovary	8.9 nTPM
Colon	8.5 nTPM
Stomach	8.5 nTPM
Kidney	6.9 nTPM
PBMC	5.6 nTPM
Spleen	4.3 nTPM
Lymph node	3.4 nTPM
Bone marrow	3.2 nTPM
Lung	3.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	9.2 nTPM
Skin	9.2 nTPM

Collecting duct cells	14.7 nTPM
Kidney	14.7 nTPM

Distal enterocytes	21.2 nTPM
Colon	21.2 nTPM
Rectum	21.1 nTPM

Early spermatids	5.9 nTPM
Testis	5.9 nTPM

Undifferentiated cells	21.4 nTPM
Rectum	23.5 nTPM
Colon	21.2 nTPM
Small intestine	19.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC