Single cell type - MYO9B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MYO9B
Gene descriptionⁱ Full gene name according to HGNC.	Myosin IXB
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Photoreceptor cells - Phototransduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MYO9B is part of cluster 9 Photoreceptor cells - Phototransduction with confidenceⁱ 1
227 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GRIPAP1	GRIP1 associated protein 1	0.5287	9
CLEC4F	C-type lectin domain family 4 member F	0.5227	19
GNAI3	G protein subunit alpha i3	0.5199	41
SLC2A11	Solute carrier family 2 member 11	0.5176	9
MPP4	Membrane palmitoylated protein 4	0.5162	9
WFDC13	WAP four-disulfide core domain 13	0.5075	9
UBAP1L	Ubiquitin associated protein 1 like	0.5036	9
CEP170B	Centrosomal protein 170B	0.5032	9
PDE6H	Phosphodiesterase 6H	0.5026	9
OPN1MW3	Opsin 1, medium wave sensitive 3	0.5017	9
SPTBN5	Spectrin beta, non-erythrocytic 5	0.5013	9
ARR3	Arrestin 3	0.5001	9
OPN1LW	Opsin 1, long wave sensitive	0.4995	9
HTT	Huntingtin	0.4883	9
GRK7	G protein-coupled receptor kinase 7	0.4845	9

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.5 nTPM
Adipose tissue	23.7 nTPM
Breast	17.3 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	23.0 nTPM
Lung	23.0 nTPM

Astrocytes	17.0 nTPM
Brain	17.0 nTPM

B-cells	47.2 nTPM
Stomach	62.2 nTPM
Adipose tissue	52.7 nTPM
Lymph node	52.7 nTPM
Bone marrow	51.5 nTPM
Spleen	47.1 nTPM
Colon	46.4 nTPM
Breast	45.4 nTPM
PBMC	44.2 nTPM
Kidney	42.9 nTPM
Liver	27.0 nTPM

Dendritic cells	43.5 nTPM
Adipose tissue	53.1 nTPM
Breast	45.6 nTPM
PBMC	31.8 nTPM

Endothelial cells	28.9 nTPM
Ovary	61.5 nTPM
Testis	39.7 nTPM
Eye	38.0 nTPM
Lung	37.4 nTPM
Pancreas	34.7 nTPM
Skeletal muscle	34.3 nTPM
Heart muscle	29.1 nTPM
Endometrium	24.4 nTPM
Prostate	23.4 nTPM
Skin	20.0 nTPM
Esophagus	20.0 nTPM
Placenta	18.2 nTPM
Breast	13.4 nTPM
Liver	10.1 nTPM

Fibroblasts	22.2 nTPM
Prostate	45.4 nTPM
Stomach	35.6 nTPM
Skin	28.4 nTPM
Skeletal muscle	25.1 nTPM
Ovary	20.9 nTPM
Adipose tissue	20.4 nTPM
Heart muscle	18.3 nTPM
Lung	16.8 nTPM
Placenta	15.1 nTPM
Breast	10.3 nTPM
Esophagus	8.4 nTPM

Intestinal goblet cells	14.8 nTPM
Colon	20.1 nTPM
Rectum	14.4 nTPM
Small intestine	10.0 nTPM

Macrophages	103.6 nTPM
Stomach	167.0 nTPM
Prostate	143.4 nTPM
Skeletal muscle	132.6 nTPM
Adipose tissue	129.8 nTPM
Ovary	129.1 nTPM
Spleen	125.5 nTPM
Lung	117.6 nTPM
Kidney	108.1 nTPM
Bone marrow	102.5 nTPM
Endometrium	100.8 nTPM
Esophagus	86.6 nTPM
Breast	75.1 nTPM
Pancreas	74.0 nTPM
Testis	48.3 nTPM
PBMC	13.6 nTPM

Paneth cells	18.2 nTPM
Colon	32.9 nTPM
Rectum	14.0 nTPM
Small intestine	7.5 nTPM

Plasma cells	37.2 nTPM
Adipose tissue	81.9 nTPM
Bone marrow	39.5 nTPM
Esophagus	24.6 nTPM
Stomach	21.0 nTPM
Spleen	18.9 nTPM

Respiratory ciliated cells	9.6 nTPM
Bronchus	12.0 nTPM
Lung	7.3 nTPM

Smooth muscle cells	24.6 nTPM
Prostate	37.9 nTPM
Heart muscle	36.7 nTPM
Endometrium	34.2 nTPM
Pancreas	31.3 nTPM
Ovary	25.5 nTPM
Skin	22.6 nTPM
Breast	22.1 nTPM
Skeletal muscle	21.9 nTPM
Adipose tissue	20.8 nTPM
Esophagus	17.0 nTPM
Bronchus	0.9 nTPM

T-cells	47.0 nTPM
Endometrium	76.2 nTPM
Skeletal muscle	75.1 nTPM
Stomach	68.3 nTPM
Breast	61.0 nTPM
Ovary	53.4 nTPM
Adipose tissue	48.9 nTPM
Colon	46.6 nTPM
Liver	45.2 nTPM
Bone marrow	43.1 nTPM
Lymph node	38.9 nTPM
Kidney	38.3 nTPM
Lung	36.5 nTPM
Skin	36.4 nTPM
Spleen	34.9 nTPM
Prostate	33.1 nTPM
Esophagus	32.8 nTPM
PBMC	29.8 nTPM

Basal keratinocytes	19.6 nTPM
Skin	19.6 nTPM

Basal prostatic cells	70.3 nTPM
Prostate	70.3 nTPM

Basal respiratory cells	9.9 nTPM
Bronchus	9.9 nTPM

Basal squamous epithelial cells	10.8 nTPM
Esophagus	10.8 nTPM

Undifferentiated cells	17.1 nTPM
Colon	25.9 nTPM
Rectum	15.2 nTPM
Small intestine	10.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC