Single cell type - NDUFB7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFB7
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit B7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFB7 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NDUFS6	NADH:ubiquinone oxidoreductase subunit S6	0.7528	39
ADAP1	ArfGAP with dual PH domains 1	0.7345	53
UGT2B17	UDP glucuronosyltransferase family 2 member B17	0.7330	53
C10orf99	Chromosome 10 open reading frame 99	0.7066	53
PDE4C	Phosphodiesterase 4C	0.6970	53
CHCHD10	Coiled-coil-helix-coiled-coil-helix domain containing 10	0.6814	39
HSD11B2	Hydroxysteroid 11-beta dehydrogenase 2	0.6793	53
MPND	MPN domain containing	0.6528	53
FP565260.2	Novel protein	0.6508	53
RABL6	RAB, member RAS oncogene family like 6	0.6475	53
CYC1	Cytochrome c1	0.6409	39
MRPL23	Mitochondrial ribosomal protein L23	0.6403	53
MOGAT3	Monoacylglycerol O-acyltransferase 3	0.6387	53
MRPL12	Mitochondrial ribosomal protein L12	0.6374	53
TMEM141	Transmembrane protein 141	0.6366	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	196.4 nTPM
Breast	263.4 nTPM
Adipose tissue	129.3 nTPM

Alveolar cells type 1	76.9 nTPM
Lung	76.9 nTPM

Alveolar cells type 2	95.9 nTPM
Lung	95.9 nTPM

Astrocytes	19.9 nTPM
Brain	19.9 nTPM

B-cells	155.6 nTPM
Liver	396.7 nTPM
Breast	240.8 nTPM
Kidney	195.2 nTPM
PBMC	167.0 nTPM
Colon	147.0 nTPM
Spleen	101.1 nTPM
Bone marrow	92.3 nTPM
Stomach	88.5 nTPM
Adipose tissue	72.2 nTPM
Lymph node	55.5 nTPM

Basal squamous epithelial cells	126.9 nTPM
Esophagus	126.9 nTPM

Dendritic cells	155.5 nTPM
Breast	190.6 nTPM
PBMC	143.4 nTPM
Adipose tissue	132.4 nTPM

Distal enterocytes	937.3 nTPM
Colon	1255.8 nTPM
Rectum	618.8 nTPM

Endothelial cells	163.5 nTPM
Placenta	245.0 nTPM
Breast	237.0 nTPM
Pancreas	212.4 nTPM
Ovary	203.9 nTPM
Heart muscle	195.3 nTPM
Testis	188.5 nTPM
Skin	181.3 nTPM
Liver	171.5 nTPM
Eye	163.4 nTPM
Skeletal muscle	133.3 nTPM
Endometrium	102.2 nTPM
Esophagus	90.6 nTPM
Lung	84.2 nTPM
Prostate	79.9 nTPM

Enteroendocrine cells	332.1 nTPM
Rectum	337.3 nTPM
Colon	326.9 nTPM

Erythroid cells	152.9 nTPM
Liver	203.4 nTPM
Bone marrow	102.5 nTPM

Fibroblasts	185.2 nTPM
Heart muscle	357.1 nTPM
Placenta	298.4 nTPM
Breast	230.3 nTPM
Ovary	217.2 nTPM
Skin	203.7 nTPM
Adipose tissue	201.4 nTPM
Skeletal muscle	136.8 nTPM
Esophagus	133.5 nTPM
Lung	102.7 nTPM
Stomach	96.5 nTPM
Prostate	60.1 nTPM

Intestinal goblet cells	639.3 nTPM
Colon	975.5 nTPM
Rectum	507.6 nTPM
Small intestine	434.7 nTPM

Macrophages	173.9 nTPM
Kidney	379.6 nTPM
Pancreas	342.1 nTPM
Ovary	223.4 nTPM
Testis	220.7 nTPM
Spleen	170.1 nTPM
Bone marrow	152.5 nTPM
Breast	150.2 nTPM
Stomach	146.6 nTPM
Prostate	139.9 nTPM
Lung	137.8 nTPM
Endometrium	134.0 nTPM
Adipose tissue	117.0 nTPM
Skeletal muscle	113.4 nTPM
Esophagus	113.3 nTPM
PBMC	68.2 nTPM

Paneth cells	720.8 nTPM
Colon	1103.4 nTPM
Small intestine	585.7 nTPM
Rectum	473.4 nTPM

Cholangiocytes	245.9 nTPM
Liver	245.9 nTPM

Collecting duct cells	259.3 nTPM
Kidney	259.3 nTPM

Cone photoreceptor cells	56.3 nTPM
Eye	56.3 nTPM

Cytotrophoblasts	359.7 nTPM
Placenta	359.7 nTPM

Plasma cells	197.5 nTPM
Spleen	280.3 nTPM
Bone marrow	229.1 nTPM
Stomach	223.9 nTPM
Esophagus	147.9 nTPM
Adipose tissue	106.5 nTPM

Respiratory ciliated cells	193.1 nTPM
Bronchus	233.1 nTPM
Lung	153.1 nTPM

Smooth muscle cells	330.8 nTPM
Bronchus	591.9 nTPM
Heart muscle	530.8 nTPM
Breast	445.9 nTPM
Skin	327.1 nTPM
Esophagus	311.6 nTPM
Pancreas	307.1 nTPM
Skeletal muscle	299.4 nTPM
Adipose tissue	266.5 nTPM
Ovary	232.4 nTPM
Prostate	186.3 nTPM
Endometrium	139.8 nTPM

T-cells	138.6 nTPM
Kidney	287.5 nTPM
Liver	188.3 nTPM
PBMC	188.1 nTPM
Skin	184.7 nTPM
Ovary	166.8 nTPM
Colon	155.9 nTPM
Skeletal muscle	154.3 nTPM
Breast	132.0 nTPM
Stomach	119.2 nTPM
Prostate	118.3 nTPM
Bone marrow	117.9 nTPM
Spleen	111.6 nTPM
Lung	101.7 nTPM
Adipose tissue	94.6 nTPM
Endometrium	93.0 nTPM
Lymph node	76.2 nTPM
Esophagus	65.5 nTPM

Undifferentiated cells	631.6 nTPM
Colon	840.7 nTPM
Rectum	599.6 nTPM
Small intestine	454.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC