Single cell type - SNAP29 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SNAP29
Gene descriptionⁱ Full gene name according to HGNC.	Synaptosome associated protein 29
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Flagellum & Golgi organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (K-562)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SNAP29 is part of cluster 23 Spermatids - Flagellum & Golgi organization with confidenceⁱ 1
311 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GOLGA6L10	Golgin A6 family like 10	0.6345	23
ANKRD61	Ankyrin repeat domain 61	0.6312	23
NLRP4	NLR family pyrin domain containing 4	0.6195	23
FAM47C	Family with sequence similarity 47 member C	0.6169	23
ZNF560	Zinc finger protein 560	0.6149	23
C1orf105	Chromosome 1 open reading frame 105	0.6145	23
RTP2	Receptor transporter protein 2	0.6141	23
EFCAB9	EF-hand calcium binding domain 9	0.6136	23
IZUMO3	IZUMO family member 3	0.6127	23
C7orf61	Chromosome 7 open reading frame 61	0.6082	23
OR4N2	Olfactory receptor family 4 subfamily N member 2	0.6060	23
SEL1L2	SEL1L2 adaptor subunit of ERAD E3 ligase	0.6026	23
RGSL1	Regulator of G protein signaling like 1	0.6026	23
LYZL4	Lysozyme like 4	0.6022	23
NUTM1	NUT midline carcinoma family member 1	0.6002	23

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	24.4 nTPM
Breast	26.8 nTPM
Adipose tissue	21.9 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	29.0 nTPM
Lung	29.0 nTPM

Astrocytes	8.8 nTPM
Brain	8.8 nTPM

B-cells	19.0 nTPM
Liver	33.6 nTPM
PBMC	25.7 nTPM
Colon	22.3 nTPM
Spleen	19.7 nTPM
Kidney	19.0 nTPM
Bone marrow	17.2 nTPM
Stomach	14.5 nTPM
Adipose tissue	13.0 nTPM
Lymph node	13.0 nTPM
Breast	12.1 nTPM

Dendritic cells	35.9 nTPM
PBMC	59.8 nTPM
Adipose tissue	27.9 nTPM
Breast	20.0 nTPM

Endothelial cells	30.1 nTPM
Liver	43.1 nTPM
Pancreas	42.5 nTPM
Placenta	36.9 nTPM
Testis	36.4 nTPM
Prostate	33.6 nTPM
Esophagus	29.8 nTPM
Ovary	28.9 nTPM
Eye	28.3 nTPM
Skin	26.9 nTPM
Skeletal muscle	25.7 nTPM
Heart muscle	24.7 nTPM
Lung	21.8 nTPM
Endometrium	21.6 nTPM
Breast	21.0 nTPM

Fibroblasts	28.4 nTPM
Placenta	41.5 nTPM
Lung	36.9 nTPM
Ovary	36.2 nTPM
Esophagus	33.8 nTPM
Skeletal muscle	27.2 nTPM
Heart muscle	27.0 nTPM
Adipose tissue	26.7 nTPM
Breast	23.1 nTPM
Prostate	21.5 nTPM
Stomach	19.3 nTPM
Skin	18.7 nTPM

Intestinal goblet cells	27.6 nTPM
Rectum	30.2 nTPM
Small intestine	26.8 nTPM
Colon	25.7 nTPM

Macrophages	46.7 nTPM
Ovary	80.8 nTPM
PBMC	68.2 nTPM
Kidney	56.0 nTPM
Pancreas	53.7 nTPM
Prostate	52.7 nTPM
Bone marrow	47.5 nTPM
Esophagus	45.6 nTPM
Lung	42.9 nTPM
Endometrium	41.7 nTPM
Testis	40.1 nTPM
Spleen	39.4 nTPM
Stomach	35.1 nTPM
Skeletal muscle	34.8 nTPM
Adipose tissue	32.4 nTPM
Breast	29.0 nTPM

Paneth cells	21.4 nTPM
Rectum	29.6 nTPM
Colon	19.7 nTPM
Small intestine	15.0 nTPM

Plasma cells	44.1 nTPM
Bone marrow	69.2 nTPM
Spleen	54.4 nTPM
Esophagus	49.4 nTPM
Stomach	31.9 nTPM
Adipose tissue	15.5 nTPM

Respiratory ciliated cells	37.4 nTPM
Lung	45.2 nTPM
Bronchus	29.5 nTPM

Smooth muscle cells	27.9 nTPM
Pancreas	56.0 nTPM
Bronchus	47.1 nTPM
Ovary	29.5 nTPM
Skeletal muscle	26.2 nTPM
Adipose tissue	24.0 nTPM
Heart muscle	23.6 nTPM
Prostate	21.9 nTPM
Endometrium	21.0 nTPM
Skin	19.5 nTPM
Breast	19.2 nTPM
Esophagus	18.6 nTPM

T-cells	26.5 nTPM
Esophagus	45.9 nTPM
Prostate	42.6 nTPM
Liver	30.5 nTPM
Colon	29.0 nTPM
Stomach	28.7 nTPM
Bone marrow	27.7 nTPM
Spleen	26.5 nTPM
PBMC	25.7 nTPM
Adipose tissue	24.7 nTPM
Skeletal muscle	24.1 nTPM
Skin	24.0 nTPM
Lymph node	21.5 nTPM
Kidney	21.2 nTPM
Endometrium	21.0 nTPM
Breast	20.3 nTPM
Ovary	20.1 nTPM
Lung	16.7 nTPM

Basal prostatic cells	24.5 nTPM
Prostate	24.5 nTPM

Basal respiratory cells	34.7 nTPM
Bronchus	34.7 nTPM

Basal squamous epithelial cells	17.6 nTPM
Esophagus	17.6 nTPM

Collecting duct cells	23.9 nTPM
Kidney	23.9 nTPM

Undifferentiated cells	25.3 nTPM
Rectum	32.3 nTPM
Small intestine	24.6 nTPM
Colon	19.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC