Single cell type - TTLL12 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TTLL12
Gene descriptionⁱ Full gene name according to HGNC.	Tubulin tyrosine ligase like 12
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Squamous epithelial cells, Paneth cells, Distal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Squamous epithelial cells, Paneth cells, Distal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TTLL12 is part of cluster 61 Squamous epithelial cells - Keratinization with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RAPGEFL1	Rap guanine nucleotide exchange factor like 1	0.7127	61
SPINK5	Serine peptidase inhibitor Kazal type 5	0.6485	61
PITX1	Paired like homeodomain 1	0.6039	61
ZBTB7C	Zinc finger and BTB domain containing 7C	0.6020	61
EVPL	Envoplakin	0.6015	61
UGT1A7	UDP glucuronosyltransferase family 1 member A7	0.5995	61
DSC2	Desmocollin 2	0.5947	61
NOX1	NADPH oxidase 1	0.5924	53
KRT13	Keratin 13	0.5918	61
DSP	Desmoplakin	0.5864	61
NXPE4	Neurexophilin and PC-esterase domain family member 4	0.5863	53
PGLYRP3	Peptidoglycan recognition protein 3	0.5858	61
FAM83G	Family with sequence similarity 83 member G	0.5844	61
ELL3	Elongation factor for RNA polymerase II 3	0.5797	61
MC5R	Melanocortin 5 receptor	0.5734	61

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	3.7 nTPM
Adipose tissue	3.9 nTPM
Breast	3.6 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	6.7 nTPM
Lung	6.7 nTPM

Astrocytes	3.6 nTPM
Brain	3.6 nTPM

B-cells	6.4 nTPM
Liver	18.6 nTPM
Bone marrow	9.0 nTPM
Spleen	8.3 nTPM
Lymph node	6.5 nTPM
PBMC	5.7 nTPM
Stomach	5.0 nTPM
Colon	4.8 nTPM
Breast	4.0 nTPM
Adipose tissue	2.5 nTPM
Kidney	0.0 nTPM

Dendritic cells	3.2 nTPM
PBMC	4.0 nTPM
Breast	2.9 nTPM
Adipose tissue	2.5 nTPM

Endothelial cells	5.8 nTPM
Ovary	14.6 nTPM
Esophagus	8.8 nTPM
Endometrium	8.7 nTPM
Testis	8.3 nTPM
Liver	6.4 nTPM
Placenta	6.2 nTPM
Prostate	5.8 nTPM
Breast	5.0 nTPM
Heart muscle	4.2 nTPM
Pancreas	3.9 nTPM
Skeletal muscle	3.8 nTPM
Skin	3.5 nTPM
Eye	1.6 nTPM
Lung	0.0 nTPM

Fibroblasts	6.0 nTPM
Ovary	13.5 nTPM
Placenta	8.6 nTPM
Esophagus	7.7 nTPM
Skeletal muscle	5.4 nTPM
Adipose tissue	5.3 nTPM
Prostate	4.6 nTPM
Lung	4.5 nTPM
Stomach	4.4 nTPM
Breast	4.4 nTPM
Skin	4.0 nTPM
Heart muscle	3.2 nTPM

Intestinal goblet cells	30.6 nTPM
Rectum	42.2 nTPM
Colon	30.7 nTPM
Small intestine	18.7 nTPM

Macrophages	7.5 nTPM
Bone marrow	15.0 nTPM
Kidney	12.9 nTPM
Pancreas	12.8 nTPM
Spleen	11.4 nTPM
Ovary	10.9 nTPM
Prostate	9.1 nTPM
Endometrium	8.2 nTPM
Testis	5.8 nTPM
Skeletal muscle	5.8 nTPM
Adipose tissue	4.8 nTPM
Breast	4.7 nTPM
Lung	4.6 nTPM
Esophagus	3.1 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	56.9 nTPM
Small intestine	71.4 nTPM
Rectum	59.8 nTPM
Colon	39.6 nTPM

Plasma cells	9.4 nTPM
Spleen	22.4 nTPM
Bone marrow	13.2 nTPM
Stomach	9.3 nTPM
Adipose tissue	1.9 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	5.0 nTPM
Bronchus	7.1 nTPM
Lung	2.9 nTPM

Smooth muscle cells	7.2 nTPM
Pancreas	14.6 nTPM
Esophagus	9.3 nTPM
Prostate	8.4 nTPM
Heart muscle	7.7 nTPM
Endometrium	6.7 nTPM
Skeletal muscle	5.8 nTPM
Bronchus	5.7 nTPM
Ovary	5.7 nTPM
Breast	5.4 nTPM
Skin	4.9 nTPM
Adipose tissue	4.8 nTPM

T-cells	5.9 nTPM
Bone marrow	12.1 nTPM
Stomach	10.9 nTPM
Lymph node	9.8 nTPM
Spleen	9.0 nTPM
Ovary	8.9 nTPM
Kidney	6.9 nTPM
PBMC	6.8 nTPM
Liver	6.0 nTPM
Endometrium	5.9 nTPM
Prostate	4.7 nTPM
Skin	4.1 nTPM
Colon	3.8 nTPM
Breast	3.6 nTPM
Skeletal muscle	3.5 nTPM
Adipose tissue	2.9 nTPM
Lung	1.5 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	11.2 nTPM
Skin	11.2 nTPM

Basal respiratory cells	11.0 nTPM
Bronchus	11.0 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Undifferentiated cells	39.9 nTPM
Colon	50.9 nTPM
Rectum	43.0 nTPM
Small intestine	25.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC