Single cell type - DDHD1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DDHD1
Gene descriptionⁱ Full gene name according to HGNC.	DDHD domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Flagellum & Golgi organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Oligodendrocytes, Late spermatids, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Oligodendrocytes, Late spermatids, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DDHD1 is part of cluster 23 Spermatids - Flagellum & Golgi organization with confidenceⁱ 1
311 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
USP50	Ubiquitin specific peptidase 50	0.6351	23
TMC7	Transmembrane channel like 7	0.6137	23
C4orf45	Chromosome 4 open reading frame 45	0.6111	23
TBC1D28	TBC1 domain family member 28	0.6037	23
NSUN3	NOP2/Sun RNA methyltransferase 3	0.6011	29
CATSPER3	Cation channel sperm associated 3	0.5984	23
CDKL3	Cyclin dependent kinase like 3	0.5975	23
C11orf94	Chromosome 11 open reading frame 94	0.5943	23
C1orf185	Chromosome 1 open reading frame 185	0.5869	23
FTMT	Ferritin mitochondrial	0.5869	23
LRRC52	Leucine rich repeat containing 52	0.5864	23
C16orf92	Chromosome 16 open reading frame 92	0.5853	23
TGIF2LX	TGFB induced factor homeobox 2 like X-linked	0.5842	23
C4orf51	Chromosome 4 open reading frame 51	0.5820	23
C9orf131	Chromosome 9 open reading frame 131	0.5780	23

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.0 nTPM
Adipose tissue	14.3 nTPM
Breast	9.7 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	15.4 nTPM
Lung	15.4 nTPM

Astrocytes	69.9 nTPM
Brain	69.9 nTPM

B-cells	40.4 nTPM
Adipose tissue	64.7 nTPM
Colon	49.5 nTPM
PBMC	48.5 nTPM
Lymph node	46.8 nTPM
Spleen	44.0 nTPM
Bone marrow	40.9 nTPM
Stomach	34.1 nTPM
Liver	25.9 nTPM
Breast	25.5 nTPM
Kidney	23.8 nTPM

Dendritic cells	46.5 nTPM
Adipose tissue	69.3 nTPM
Breast	38.2 nTPM
PBMC	31.8 nTPM

Endothelial cells	19.1 nTPM
Endometrium	52.5 nTPM
Pancreas	27.0 nTPM
Esophagus	24.9 nTPM
Ovary	24.7 nTPM
Skeletal muscle	24.2 nTPM
Eye	21.8 nTPM
Placenta	19.9 nTPM
Prostate	19.8 nTPM
Testis	18.1 nTPM
Heart muscle	14.2 nTPM
Breast	8.5 nTPM
Skin	6.8 nTPM
Lung	3.1 nTPM
Liver	1.8 nTPM

Fibroblasts	25.4 nTPM
Stomach	44.6 nTPM
Ovary	43.9 nTPM
Skeletal muscle	37.1 nTPM
Adipose tissue	28.6 nTPM
Prostate	23.4 nTPM
Esophagus	21.4 nTPM
Skin	20.9 nTPM
Breast	20.1 nTPM
Lung	16.8 nTPM
Placenta	12.5 nTPM
Heart muscle	10.3 nTPM

Intestinal goblet cells	5.0 nTPM
Colon	7.8 nTPM
Rectum	5.7 nTPM
Small intestine	1.4 nTPM

Macrophages	31.5 nTPM
Endometrium	62.5 nTPM
Lung	51.6 nTPM
Prostate	51.6 nTPM
Adipose tissue	47.7 nTPM
Ovary	33.4 nTPM
Esophagus	33.1 nTPM
Skeletal muscle	31.9 nTPM
Bone marrow	27.5 nTPM
Spleen	26.0 nTPM
Kidney	23.4 nTPM
Pancreas	23.0 nTPM
Testis	22.6 nTPM
Breast	21.2 nTPM
Stomach	17.6 nTPM
PBMC	0.0 nTPM

Paneth cells	3.4 nTPM
Rectum	6.5 nTPM
Small intestine	3.7 nTPM
Colon	0.0 nTPM

Plasma cells	42.7 nTPM
Adipose tissue	60.7 nTPM
Esophagus	55.5 nTPM
Stomach	34.4 nTPM
Spleen	31.8 nTPM
Bone marrow	31.3 nTPM

Respiratory ciliated cells	6.7 nTPM
Lung	8.7 nTPM
Bronchus	4.8 nTPM

Smooth muscle cells	15.8 nTPM
Endometrium	26.4 nTPM
Adipose tissue	26.3 nTPM
Ovary	21.8 nTPM
Prostate	20.3 nTPM
Skeletal muscle	18.8 nTPM
Esophagus	17.0 nTPM
Skin	12.6 nTPM
Breast	11.9 nTPM
Pancreas	10.7 nTPM
Heart muscle	5.4 nTPM
Bronchus	2.9 nTPM

T-cells	42.4 nTPM
Ovary	69.0 nTPM
Adipose tissue	67.8 nTPM
Skeletal muscle	63.5 nTPM
Endometrium	53.3 nTPM
Colon	50.8 nTPM
Liver	44.3 nTPM
PBMC	43.5 nTPM
Bone marrow	43.4 nTPM
Stomach	42.4 nTPM
Lymph node	40.9 nTPM
Spleen	40.2 nTPM
Lung	38.0 nTPM
Breast	35.6 nTPM
Kidney	30.7 nTPM
Prostate	28.4 nTPM
Skin	16.6 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	6.1 nTPM
Skin	6.1 nTPM

Basal prostatic cells	7.1 nTPM
Prostate	7.1 nTPM

Basal respiratory cells	3.5 nTPM
Bronchus	3.5 nTPM

Basal squamous epithelial cells	23.9 nTPM
Esophagus	23.9 nTPM

Undifferentiated cells	5.6 nTPM
Rectum	6.4 nTPM
Small intestine	5.8 nTPM
Colon	4.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC