Single cell type - ZFYVE21 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZFYVE21
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger FYVE-type containing 21
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZFYVE21 is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
A4GALT	Alpha 1,4-galactosyltransferase (P blood group)	0.6311	50
PTHLH	Parathyroid hormone like hormone	0.6088	26
CCDC71	Coiled-coil domain containing 71	0.5841	26
TM2D1	TM2 domain containing 1	0.5681	26
LOXL4	Lysyl oxidase like 4	0.5656	26
AL592183.1		0.5651	48
LEPROT	Leptin receptor overlapping transcript	0.5637	14
TM2D3	TM2 domain containing 3	0.5548	26
AC006486.1	Novel protein	0.5463	26
SKP1	S-phase kinase associated protein 1	0.5458	39
EID1	EP300 interacting inhibitor of differentiation 1	0.5428	39
KRTAP19-3	Keratin associated protein 19-3	0.5427	26
MMP13	Matrix metallopeptidase 13	0.5406	26
MRGPRX3	MAS related GPR family member X3	0.5367	26
MRGPRX4	MAS related GPR family member X4	0.5354	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	68.0 nTPM
Adipose tissue	75.6 nTPM
Breast	60.4 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	23.9 nTPM
Lung	23.9 nTPM

Astrocytes	61.7 nTPM
Brain	61.7 nTPM

B-cells	9.5 nTPM
Kidney	19.0 nTPM
Colon	17.6 nTPM
Breast	13.4 nTPM
Liver	11.0 nTPM
PBMC	9.9 nTPM
Spleen	6.2 nTPM
Bone marrow	5.7 nTPM
Adipose tissue	5.5 nTPM
Stomach	3.7 nTPM
Lymph node	3.0 nTPM

Dendritic cells	20.9 nTPM
PBMC	35.8 nTPM
Breast	18.2 nTPM
Adipose tissue	8.6 nTPM

Endothelial cells	71.0 nTPM
Testis	240.0 nTPM
Liver	88.1 nTPM
Skin	87.9 nTPM
Breast	86.1 nTPM
Prostate	77.4 nTPM
Placenta	72.7 nTPM
Skeletal muscle	55.6 nTPM
Esophagus	53.0 nTPM
Ovary	52.0 nTPM
Heart muscle	48.1 nTPM
Eye	46.9 nTPM
Pancreas	30.9 nTPM
Endometrium	30.2 nTPM
Lung	24.9 nTPM

Fibroblasts	65.3 nTPM
Placenta	85.4 nTPM
Breast	84.5 nTPM
Skin	81.4 nTPM
Adipose tissue	72.6 nTPM
Heart muscle	68.5 nTPM
Ovary	68.0 nTPM
Esophagus	62.3 nTPM
Prostate	56.2 nTPM
Stomach	55.0 nTPM
Skeletal muscle	51.5 nTPM
Lung	32.4 nTPM

Intestinal goblet cells	34.2 nTPM
Rectum	37.2 nTPM
Colon	35.1 nTPM
Small intestine	30.2 nTPM

Macrophages	28.4 nTPM
PBMC	109.1 nTPM
Pancreas	43.4 nTPM
Ovary	41.6 nTPM
Kidney	28.7 nTPM
Prostate	28.7 nTPM
Testis	28.4 nTPM
Spleen	22.8 nTPM
Breast	22.2 nTPM
Bone marrow	21.2 nTPM
Lung	18.5 nTPM
Skeletal muscle	17.5 nTPM
Endometrium	15.1 nTPM
Stomach	11.7 nTPM
Adipose tissue	11.1 nTPM
Esophagus	6.3 nTPM

Paneth cells	51.9 nTPM
Small intestine	86.3 nTPM
Rectum	56.2 nTPM
Colon	13.2 nTPM

Plasma cells	7.4 nTPM
Spleen	9.1 nTPM
Bone marrow	8.2 nTPM
Stomach	7.4 nTPM
Adipose tissue	6.4 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	47.1 nTPM
Bronchus	63.5 nTPM
Lung	30.6 nTPM

Smooth muscle cells	60.7 nTPM
Breast	108.3 nTPM
Skin	86.8 nTPM
Esophagus	83.7 nTPM
Heart muscle	81.7 nTPM
Prostate	57.5 nTPM
Skeletal muscle	50.1 nTPM
Adipose tissue	49.1 nTPM
Pancreas	42.9 nTPM
Bronchus	41.1 nTPM
Ovary	36.9 nTPM
Endometrium	29.3 nTPM

T-cells	13.4 nTPM
Skin	28.5 nTPM
Kidney	27.4 nTPM
Breast	21.6 nTPM
Liver	16.6 nTPM
Colon	15.2 nTPM
Prostate	14.2 nTPM
Bone marrow	13.4 nTPM
PBMC	12.6 nTPM
Lung	12.2 nTPM
Skeletal muscle	12.2 nTPM
Endometrium	11.5 nTPM
Spleen	11.4 nTPM
Adipose tissue	9.8 nTPM
Stomach	8.6 nTPM
Ovary	6.7 nTPM
Lymph node	6.1 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	45.5 nTPM
Skin	45.5 nTPM

Basal prostatic cells	83.5 nTPM
Prostate	83.5 nTPM

Basal respiratory cells	161.9 nTPM
Bronchus	161.9 nTPM

Cholangiocytes	41.5 nTPM
Liver	41.5 nTPM

Undifferentiated cells	32.4 nTPM
Rectum	41.1 nTPM
Colon	30.1 nTPM
Small intestine	26.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC