Single cell type - ZC3H14 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZC3H14
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger CCCH-type containing 14
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	19

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Early spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZC3H14 is part of cluster 29 Early spermatids - Spermatogenesis with confidenceⁱ 1
337 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EFCAB3	EF-hand calcium binding domain 3	0.7982	29
SPATA31D3	SPATA31 subfamily D member 3	0.7861	29
ERICH2	Glutamate rich 2	0.7818	29
ACTRT3	Actin related protein T3	0.7788	29
TBC1D3B	TBC1 domain family member 3B	0.7760	29
SPATA25	Spermatogenesis associated 25	0.7739	29
C12orf60	Chromosome 12 open reading frame 60	0.7725	29
SMIM23	Small integral membrane protein 23	0.7722	29
GOLGA6L22	Golgin A6 family like 22	0.7700	29
SPATA31D4	SPATA31 subfamily D member 4	0.7645	29
TRIML1	Tripartite motif family like 1	0.7627	29
SPACA4	Sperm acrosome associated 4	0.7590	29
CCDC27	Coiled-coil domain containing 27	0.7583	29
SUN5	Sad1 and UNC84 domain containing 5	0.7579	29
TBC1D3I	TBC1 domain family member 3I	0.7574	29

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	25.2 nTPM
Breast	27.9 nTPM
Adipose tissue	22.5 nTPM

Alveolar cells type 1	121.8 nTPM
Lung	121.8 nTPM

Alveolar cells type 2	57.0 nTPM
Lung	57.0 nTPM

Astrocytes	38.2 nTPM
Brain	38.2 nTPM

B-cells	18.1 nTPM
PBMC	29.9 nTPM
Colon	22.3 nTPM
Adipose tissue	21.6 nTPM
Breast	20.0 nTPM
Lymph node	18.5 nTPM
Bone marrow	18.0 nTPM
Spleen	16.9 nTPM
Liver	15.1 nTPM
Stomach	14.1 nTPM
Kidney	4.8 nTPM

Dendritic cells	25.4 nTPM
PBMC	27.9 nTPM
Adipose tissue	25.2 nTPM
Breast	22.9 nTPM

Endothelial cells	28.7 nTPM
Lung	68.6 nTPM
Endometrium	39.1 nTPM
Testis	35.6 nTPM
Skeletal muscle	33.2 nTPM
Ovary	30.2 nTPM
Placenta	26.1 nTPM
Eye	25.9 nTPM
Breast	22.7 nTPM
Esophagus	22.2 nTPM
Liver	22.0 nTPM
Heart muscle	20.7 nTPM
Prostate	19.7 nTPM
Pancreas	19.3 nTPM
Skin	16.7 nTPM

Fibroblasts	30.5 nTPM
Lung	63.7 nTPM
Ovary	40.9 nTPM
Skeletal muscle	39.1 nTPM
Esophagus	31.9 nTPM
Adipose tissue	29.6 nTPM
Prostate	27.5 nTPM
Breast	26.4 nTPM
Heart muscle	24.1 nTPM
Placenta	22.1 nTPM
Skin	18.8 nTPM
Stomach	11.9 nTPM

Intestinal goblet cells	31.4 nTPM
Rectum	36.2 nTPM
Colon	30.0 nTPM
Small intestine	27.9 nTPM

Macrophages	19.6 nTPM
Ovary	37.2 nTPM
Lung	32.8 nTPM
Adipose tissue	29.9 nTPM
Testis	28.4 nTPM
Breast	22.7 nTPM
Esophagus	22.0 nTPM
Skeletal muscle	20.3 nTPM
Endometrium	18.8 nTPM
Bone marrow	16.3 nTPM
Spleen	15.6 nTPM
Kidney	14.3 nTPM
PBMC	13.6 nTPM
Pancreas	10.2 nTPM
Prostate	9.1 nTPM
Stomach	2.9 nTPM

Paneth cells	16.4 nTPM
Rectum	31.1 nTPM
Small intestine	15.0 nTPM
Colon	3.3 nTPM

Plasma cells	18.6 nTPM
Bone marrow	21.4 nTPM
Adipose tissue	21.3 nTPM
Spleen	19.5 nTPM
Stomach	18.4 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	53.0 nTPM
Lung	81.6 nTPM
Bronchus	24.3 nTPM

Smooth muscle cells	35.4 nTPM
Endometrium	46.2 nTPM
Ovary	42.5 nTPM
Skeletal muscle	42.2 nTPM
Breast	36.9 nTPM
Pancreas	36.8 nTPM
Adipose tissue	35.1 nTPM
Bronchus	33.7 nTPM
Esophagus	32.5 nTPM
Heart muscle	30.4 nTPM
Prostate	26.9 nTPM
Skin	26.6 nTPM

T-cells	20.1 nTPM
Lung	34.9 nTPM
PBMC	28.4 nTPM
Endometrium	27.6 nTPM
Ovary	24.5 nTPM
Adipose tissue	24.1 nTPM
Kidney	23.3 nTPM
Breast	22.5 nTPM
Skeletal muscle	21.9 nTPM
Lymph node	21.0 nTPM
Prostate	19.0 nTPM
Colon	18.5 nTPM
Liver	17.7 nTPM
Spleen	17.1 nTPM
Stomach	16.7 nTPM
Bone marrow	16.1 nTPM
Skin	9.2 nTPM
Esophagus	0.0 nTPM

Basal squamous epithelial cells	21.1 nTPM
Esophagus	21.1 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Collecting duct cells	20.2 nTPM
Kidney	20.2 nTPM

Cone photoreceptor cells	77.2 nTPM
Eye	77.2 nTPM

Undifferentiated cells	32.8 nTPM
Rectum	39.6 nTPM
Small intestine	31.8 nTPM
Colon	27.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC