Single cell type - CCNB1IP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCNB1IP1
Gene descriptionⁱ Full gene name according to HGNC.	Cyclin B1 interacting protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (hTERT-HME1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CCNB1IP1 is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
AHCY	Adenosylhomocysteinase	0.5272	67
ECSIT	ECSIT signaling integrator	0.5192	39
NSUN7	NOP2/Sun RNA methyltransferase family member 7	0.4770	25
BEX2	Brain expressed X-linked 2	0.4764	39
RPL29	Ribosomal protein L29	0.4761	32
PRKRA	Protein activator of interferon induced protein kinase EIF2AK2	0.4759	25
ST13	ST13 Hsp70 interacting protein	0.4704	67
NOB1	NIN1 (RPN12) binding protein 1 homolog	0.4660	32
AK6	Adenylate kinase 6	0.4644	25
HIBCH	3-hydroxyisobutyryl-CoA hydrolase	0.4594	67
ETNK2	Ethanolamine kinase 2	0.4570	25
RNF7	Ring finger protein 7	0.4567	25
ATPAF1	ATP synthase mitochondrial F1 complex assembly factor 1	0.4556	34
MRPS26	Mitochondrial ribosomal protein S26	0.4500	39
PIGP	Phosphatidylinositol glycan anchor biosynthesis class P	0.4475	13

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.2 nTPM
Breast	27.2 nTPM
Adipose tissue	17.0 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	27.2 nTPM
Lung	27.2 nTPM

Astrocytes	16.3 nTPM
Brain	16.3 nTPM

B-cells	35.5 nTPM
Colon	60.7 nTPM
PBMC	48.5 nTPM
Adipose tissue	44.6 nTPM
Lymph node	34.2 nTPM
Stomach	34.1 nTPM
Bone marrow	30.2 nTPM
Kidney	28.5 nTPM
Spleen	28.0 nTPM
Breast	24.1 nTPM
Liver	21.7 nTPM

Basal squamous epithelial cells	113.3 nTPM
Esophagus	113.3 nTPM

Dendritic cells	27.7 nTPM
Breast	29.9 nTPM
PBMC	27.9 nTPM
Adipose tissue	25.2 nTPM

Endothelial cells	24.9 nTPM
Prostate	45.1 nTPM
Breast	33.5 nTPM
Skin	32.1 nTPM
Testis	32.0 nTPM
Ovary	31.5 nTPM
Esophagus	30.5 nTPM
Placenta	29.6 nTPM
Endometrium	25.2 nTPM
Skeletal muscle	18.0 nTPM
Liver	17.4 nTPM
Eye	16.2 nTPM
Pancreas	15.5 nTPM
Lung	12.5 nTPM
Heart muscle	9.1 nTPM

Fibroblasts	34.5 nTPM
Prostate	57.2 nTPM
Ovary	46.1 nTPM
Esophagus	41.6 nTPM
Breast	40.0 nTPM
Placenta	36.6 nTPM
Adipose tissue	35.1 nTPM
Skin	34.1 nTPM
Stomach	31.2 nTPM
Skeletal muscle	25.5 nTPM
Heart muscle	17.8 nTPM
Lung	14.5 nTPM

Intestinal goblet cells	40.1 nTPM
Colon	45.8 nTPM
Rectum	44.0 nTPM
Small intestine	30.7 nTPM

Macrophages	22.4 nTPM
Prostate	55.1 nTPM
Testis	40.7 nTPM
Breast	31.1 nTPM
Adipose tissue	30.5 nTPM
Esophagus	26.8 nTPM
Endometrium	24.3 nTPM
Ovary	22.2 nTPM
Kidney	19.6 nTPM
Lung	19.6 nTPM
Bone marrow	18.8 nTPM
Skeletal muscle	16.1 nTPM
PBMC	13.6 nTPM
Stomach	8.8 nTPM
Pancreas	5.1 nTPM
Spleen	4.2 nTPM

Paneth cells	18.8 nTPM
Rectum	34.8 nTPM
Small intestine	15.0 nTPM
Colon	6.5 nTPM

Plasma cells	17.4 nTPM
Adipose tissue	20.6 nTPM
Esophagus	18.4 nTPM
Spleen	17.9 nTPM
Stomach	17.1 nTPM
Bone marrow	13.2 nTPM

Respiratory ciliated cells	5.2 nTPM
Bronchus	6.1 nTPM
Lung	4.4 nTPM

Smooth muscle cells	31.6 nTPM
Ovary	59.8 nTPM
Prostate	57.9 nTPM
Esophagus	37.2 nTPM
Endometrium	36.7 nTPM
Breast	35.9 nTPM
Adipose tissue	34.8 nTPM
Pancreas	29.8 nTPM
Skin	23.7 nTPM
Skeletal muscle	22.9 nTPM
Heart muscle	7.3 nTPM
Bronchus	1.8 nTPM

Cholangiocytes	58.6 nTPM
Liver	58.6 nTPM

Collecting duct cells	23.9 nTPM
Kidney	23.9 nTPM

Cone photoreceptor cells	20.9 nTPM
Eye	20.9 nTPM

Cytotrophoblasts	41.2 nTPM
Placenta	41.2 nTPM

T-cells	28.7 nTPM
Prostate	42.6 nTPM
PBMC	40.8 nTPM
Skin	35.9 nTPM
Liver	34.3 nTPM
Adipose tissue	34.0 nTPM
Breast	30.9 nTPM
Lymph node	30.1 nTPM
Colon	29.5 nTPM
Bone marrow	27.0 nTPM
Esophagus	26.2 nTPM
Spleen	25.0 nTPM
Stomach	24.7 nTPM
Skeletal muscle	23.6 nTPM
Ovary	22.3 nTPM
Lung	21.3 nTPM
Endometrium	20.8 nTPM
Kidney	19.1 nTPM

Undifferentiated cells	44.3 nTPM
Small intestine	51.9 nTPM
Colon	41.0 nTPM
Rectum	39.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC