Single cell type - PRPS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRPS2
Gene descriptionⁱ Full gene name according to HGNC.	Phosphoribosyl pyrophosphate synthetase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Peritubular cells, Leydig cells, Sertoli cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Peritubular cells, Leydig cells, Sertoli cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PRPS2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PROK1	Prokineticin 1	0.9024	52
PTGDS	Prostaglandin D2 synthase	0.8426	52
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.7959	52
SPINK13	Serine peptidase inhibitor Kazal type 13	0.7937	44
TCEAL1	Transcription elongation factor A like 1	0.7671	48
LHX9	LIM homeobox 9	0.7667	52
KCNMB1	Potassium calcium-activated channel subfamily M regulatory beta subunit 1	0.7488	48
LAMC3	Laminin subunit gamma 3	0.7468	52
GLI1	GLI family zinc finger 1	0.7417	52
TCF23	Transcription factor 23	0.7092	48
HEYL	Hes related family bHLH transcription factor with YRPW motif like	0.7090	48
IL17B	Interleukin 17B	0.6626	48
FOXS1	Forkhead box S1	0.6587	48
NR2F2	Nuclear receptor subfamily 2 group F member 2	0.6539	48
TCEAL4	Transcription elongation factor A like 4	0.6529	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.2 nTPM
Adipose tissue	14.1 nTPM
Breast	10.3 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	8.7 nTPM
Lung	8.7 nTPM

Astrocytes	0.7 nTPM
Brain	0.7 nTPM

B-cells	25.4 nTPM
Kidney	42.9 nTPM
Liver	33.8 nTPM
Spleen	29.7 nTPM
Lymph node	27.8 nTPM
Bone marrow	27.8 nTPM
Stomach	23.6 nTPM
PBMC	22.8 nTPM
Colon	17.6 nTPM
Adipose tissue	16.1 nTPM
Breast	12.1 nTPM

Dendritic cells	18.5 nTPM
PBMC	20.0 nTPM
Adipose tissue	19.3 nTPM
Breast	16.4 nTPM

Endothelial cells	14.5 nTPM
Testis	36.1 nTPM
Skin	26.5 nTPM
Esophagus	19.6 nTPM
Prostate	19.4 nTPM
Ovary	14.8 nTPM
Breast	13.3 nTPM
Liver	12.8 nTPM
Pancreas	11.6 nTPM
Endometrium	11.2 nTPM
Skeletal muscle	9.8 nTPM
Lung	9.3 nTPM
Eye	8.1 nTPM
Heart muscle	6.1 nTPM
Placenta	4.0 nTPM

Fibroblasts	25.8 nTPM
Prostate	69.4 nTPM
Ovary	54.6 nTPM
Skin	31.6 nTPM
Adipose tissue	24.7 nTPM
Esophagus	19.1 nTPM
Breast	17.3 nTPM
Placenta	15.7 nTPM
Lung	14.5 nTPM
Skeletal muscle	14.5 nTPM
Stomach	13.4 nTPM
Heart muscle	8.7 nTPM

Intestinal goblet cells	27.9 nTPM
Rectum	39.8 nTPM
Small intestine	25.3 nTPM
Colon	18.6 nTPM

Macrophages	20.7 nTPM
Testis	40.7 nTPM
Esophagus	28.3 nTPM
Pancreas	28.0 nTPM
Prostate	25.3 nTPM
Adipose tissue	25.2 nTPM
Spleen	23.9 nTPM
Breast	22.6 nTPM
Stomach	20.5 nTPM
Endometrium	17.5 nTPM
Ovary	17.5 nTPM
Lung	17.3 nTPM
Skeletal muscle	16.7 nTPM
Bone marrow	15.0 nTPM
Kidney	11.4 nTPM
PBMC	0.0 nTPM

Paneth cells	17.4 nTPM
Rectum	45.7 nTPM
Colon	6.5 nTPM
Small intestine	0.0 nTPM

Plasma cells	30.7 nTPM
Spleen	51.7 nTPM
Stomach	37.3 nTPM
Bone marrow	33.0 nTPM
Adipose tissue	19.4 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	20.3 nTPM
Lung	23.3 nTPM
Bronchus	17.3 nTPM

Smooth muscle cells	19.2 nTPM
Prostate	60.9 nTPM
Skin	29.3 nTPM
Ovary	27.3 nTPM
Pancreas	22.1 nTPM
Endometrium	19.3 nTPM
Adipose tissue	16.8 nTPM
Breast	12.4 nTPM
Esophagus	9.3 nTPM
Bronchus	6.5 nTPM
Skeletal muscle	4.8 nTPM
Heart muscle	2.2 nTPM

T-cells	27.2 nTPM
Prostate	61.6 nTPM
Skin	48.3 nTPM
Colon	31.8 nTPM
Kidney	31.5 nTPM
Lymph node	30.0 nTPM
Ovary	28.9 nTPM
Spleen	28.4 nTPM
Breast	28.3 nTPM
Esophagus	26.2 nTPM
Adipose tissue	25.8 nTPM
Stomach	22.7 nTPM
PBMC	21.6 nTPM
Bone marrow	19.6 nTPM
Liver	19.4 nTPM
Endometrium	18.2 nTPM
Skeletal muscle	13.7 nTPM
Lung	6.1 nTPM

Basal keratinocytes	64.0 nTPM
Skin	64.0 nTPM

Basal prostatic cells	48.5 nTPM
Prostate	48.5 nTPM

Basal respiratory cells	16.2 nTPM
Bronchus	16.2 nTPM

Basal squamous epithelial cells	41.5 nTPM
Esophagus	41.5 nTPM

Undifferentiated cells	50.2 nTPM
Rectum	62.8 nTPM
Small intestine	45.2 nTPM
Colon	42.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC