Single cell type - MAGED2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAGED2
Gene descriptionⁱ Full gene name according to HGNC.	MAGE family member D2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulosa cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Granulosa cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Granulosa cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MAGED2 is part of cluster 40 Granulosa cells - Unknown function with confidenceⁱ 1
316 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CRYGD	Crystallin gamma D	0.8862	40
AMH	Anti-Mullerian hormone	0.8857	40
NECTIN1	Nectin cell adhesion molecule 1	0.8730	40
CEACAM21	CEA cell adhesion molecule 21	0.8579	40
DCAF12L2	DDB1 and CUL4 associated factor 12 like 2	0.8579	40
IHH	Indian hedgehog signaling molecule	0.8531	40
INHBB	Inhibin subunit beta B	0.8500	40
ELK1	ETS transcription factor ELK1	0.8494	40
OR8D4	Olfactory receptor family 8 subfamily D member 4	0.8464	40
DHH	Desert hedgehog signaling molecule	0.8410	40
BAMBI	BMP and activin membrane bound inhibitor	0.8252	40
NDP	Norrin cystine knot growth factor NDP	0.8194	40
ZNF275	Zinc finger protein 275	0.8139	40
CRHBP	Corticotropin releasing hormone binding protein	0.8137	40
RIMS4	Regulating synaptic membrane exocytosis 4	0.8124	40

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	77.9 nTPM
Breast	91.3 nTPM
Adipose tissue	64.4 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	42.8 nTPM
Lung	42.8 nTPM

Astrocytes	17.6 nTPM
Brain	17.6 nTPM

B-cells	37.4 nTPM
Breast	56.2 nTPM
Liver	50.9 nTPM
Stomach	48.6 nTPM
PBMC	42.8 nTPM
Lymph node	38.3 nTPM
Kidney	38.1 nTPM
Bone marrow	29.4 nTPM
Colon	25.5 nTPM
Adipose tissue	22.5 nTPM
Spleen	21.1 nTPM

Dendritic cells	36.9 nTPM
Breast	45.2 nTPM
Adipose tissue	33.6 nTPM
PBMC	31.8 nTPM

Endothelial cells	116.4 nTPM
Placenta	325.1 nTPM
Ovary	322.5 nTPM
Eye	144.0 nTPM
Pancreas	139.0 nTPM
Testis	119.4 nTPM
Heart muscle	87.6 nTPM
Skeletal muscle	78.7 nTPM
Endometrium	66.0 nTPM
Esophagus	65.3 nTPM
Breast	62.3 nTPM
Skin	58.3 nTPM
Lung	56.1 nTPM
Prostate	54.4 nTPM
Liver	51.3 nTPM

Fibroblasts	151.7 nTPM
Placenta	513.1 nTPM
Ovary	217.2 nTPM
Breast	181.0 nTPM
Adipose tissue	114.9 nTPM
Skeletal muscle	110.2 nTPM
Heart muscle	102.0 nTPM
Esophagus	101.4 nTPM
Stomach	98.0 nTPM
Skin	91.9 nTPM
Prostate	80.2 nTPM
Lung	59.2 nTPM

Intestinal goblet cells	48.8 nTPM
Colon	52.9 nTPM
Small intestine	48.3 nTPM
Rectum	45.3 nTPM

Macrophages	41.1 nTPM
PBMC	177.3 nTPM
Ovary	85.0 nTPM
Breast	58.2 nTPM
Prostate	51.6 nTPM
Pancreas	51.0 nTPM
Testis	34.3 nTPM
Kidney	23.4 nTPM
Adipose tissue	22.9 nTPM
Bone marrow	20.0 nTPM
Skeletal muscle	18.1 nTPM
Endometrium	17.5 nTPM
Lung	17.0 nTPM
Esophagus	15.8 nTPM
Stomach	14.7 nTPM
Spleen	9.3 nTPM

Paneth cells	33.7 nTPM
Small intestine	48.8 nTPM
Rectum	35.7 nTPM
Colon	16.5 nTPM

Plasma cells	46.7 nTPM
Stomach	101.7 nTPM
Spleen	38.4 nTPM
Esophagus	36.9 nTPM
Bone marrow	29.7 nTPM
Adipose tissue	27.1 nTPM

Respiratory ciliated cells	119.9 nTPM
Bronchus	166.9 nTPM
Lung	72.9 nTPM

Smooth muscle cells	236.3 nTPM
Ovary	753.1 nTPM
Bronchus	314.8 nTPM
Pancreas	295.1 nTPM
Breast	208.1 nTPM
Heart muscle	182.2 nTPM
Adipose tissue	170.7 nTPM
Skeletal muscle	160.6 nTPM
Skin	146.8 nTPM
Esophagus	138.0 nTPM
Endometrium	118.5 nTPM
Prostate	111.3 nTPM

T-cells	51.4 nTPM
Kidney	77.4 nTPM
Prostate	75.7 nTPM
Skin	74.1 nTPM
Ovary	73.4 nTPM
Stomach	72.9 nTPM
Breast	68.0 nTPM
Colon	49.4 nTPM
Lung	48.6 nTPM
Lymph node	48.6 nTPM
Liver	41.2 nTPM
Endometrium	40.0 nTPM
PBMC	38.7 nTPM
Skeletal muscle	38.3 nTPM
Adipose tissue	36.8 nTPM
Bone marrow	35.8 nTPM
Spleen	35.7 nTPM
Esophagus	19.7 nTPM

Basal keratinocytes	42.4 nTPM
Skin	42.4 nTPM

Basal prostatic cells	96.4 nTPM
Prostate	96.4 nTPM

Basal respiratory cells	198.6 nTPM
Bronchus	198.6 nTPM

Basal squamous epithelial cells	43.3 nTPM
Esophagus	43.3 nTPM

Undifferentiated cells	25.3 nTPM
Rectum	28.5 nTPM
Small intestine	27.8 nTPM
Colon	19.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC