Single cell type - NFAT5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NFAT5
Gene descriptionⁱ Full gene name according to HGNC.	Nuclear factor of activated T cells 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SiHa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NFAT5 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NUP153	Nucleoporin 153	0.6586	44
PTPN14	Protein tyrosine phosphatase non-receptor type 14	0.6149	14
GPR75	G protein-coupled receptor 75	0.6114	44
KMT2C	Lysine methyltransferase 2C	0.6105	44
BX276092.9	Chromosome X open reading frame 49-like	0.6098	44
RC3H1	Ring finger and CCCH-type domains 1	0.6089	44
JMJD1C	Jumonji domain containing 1C	0.6062	44
KRTAP4-8	Keratin associated protein 4-8	0.5979	44
SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	0.5972	44
KRTAP4-9	Keratin associated protein 4-9	0.5933	44
CLEC20A	C-type lectin domain containing 20A	0.5820	44
TSC22D2	TSC22 domain family member 2	0.5819	44
TNFRSF10B	TNF receptor superfamily member 10b	0.5764	44
OVGP1	Oviductal glycoprotein 1	0.5754	44
ARHGEF12	Rho guanine nucleotide exchange factor 12	0.5737	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	65.0 nTPM
Adipose tissue	87.2 nTPM
Breast	42.9 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	49.7 nTPM
Lung	49.7 nTPM

Astrocytes	236.7 nTPM
Brain	236.7 nTPM

B-cells	55.7 nTPM
Lymph node	102.2 nTPM
Adipose tissue	93.8 nTPM
Spleen	67.9 nTPM
Colon	62.3 nTPM
Stomach	60.0 nTPM
Bone marrow	43.4 nTPM
Breast	38.8 nTPM
PBMC	37.1 nTPM
Kidney	33.4 nTPM
Liver	18.6 nTPM

Basal squamous epithelial cells	155.4 nTPM
Esophagus	155.4 nTPM

Dendritic cells	69.4 nTPM
Adipose tissue	133.1 nTPM
Breast	47.0 nTPM
PBMC	27.9 nTPM

Endothelial cells	93.6 nTPM
Endometrium	340.8 nTPM
Prostate	148.3 nTPM
Skin	132.2 nTPM
Esophagus	100.3 nTPM
Skeletal muscle	83.6 nTPM
Lung	68.6 nTPM
Testis	67.9 nTPM
Liver	66.9 nTPM
Eye	66.3 nTPM
Breast	64.2 nTPM
Placenta	59.1 nTPM
Ovary	52.8 nTPM
Heart muscle	47.8 nTPM
Pancreas	11.6 nTPM

Fibroblasts	60.9 nTPM
Skin	103.2 nTPM
Prostate	102.6 nTPM
Skeletal muscle	76.9 nTPM
Adipose tissue	73.1 nTPM
Esophagus	69.5 nTPM
Stomach	68.3 nTPM
Breast	48.4 nTPM
Placenta	39.3 nTPM
Heart muscle	31.7 nTPM
Ovary	30.7 nTPM
Lung	25.7 nTPM

Intestinal goblet cells	29.1 nTPM
Rectum	41.3 nTPM
Small intestine	24.1 nTPM
Colon	22.1 nTPM

Macrophages	58.2 nTPM
Endometrium	144.2 nTPM
Adipose tissue	125.1 nTPM
Prostate	84.8 nTPM
Stomach	82.1 nTPM
Skeletal muscle	66.4 nTPM
Esophagus	56.6 nTPM
Breast	56.3 nTPM
Bone marrow	52.4 nTPM
Spleen	51.8 nTPM
Kidney	46.2 nTPM
Testis	33.1 nTPM
Ovary	27.1 nTPM
Lung	26.3 nTPM
Pancreas	20.4 nTPM
PBMC	0.0 nTPM

Paneth cells	29.3 nTPM
Colon	39.6 nTPM
Small intestine	26.3 nTPM
Rectum	22.0 nTPM

Plasma cells	50.2 nTPM
Adipose tissue	123.8 nTPM
Esophagus	67.8 nTPM
Stomach	31.1 nTPM
Spleen	18.2 nTPM
Bone marrow	9.9 nTPM

Respiratory ciliated cells	31.8 nTPM
Bronchus	44.6 nTPM
Lung	19.0 nTPM

Smooth muscle cells	51.4 nTPM
Endometrium	100.9 nTPM
Prostate	85.7 nTPM
Skin	72.8 nTPM
Adipose tissue	67.2 nTPM
Skeletal muscle	49.9 nTPM
Esophagus	44.9 nTPM
Ovary	40.4 nTPM
Bronchus	36.9 nTPM
Breast	36.7 nTPM
Heart muscle	15.1 nTPM
Pancreas	15.1 nTPM

Cholangiocytes	30.0 nTPM
Liver	30.0 nTPM

Collecting duct cells	145.3 nTPM
Kidney	145.3 nTPM

Cone photoreceptor cells	85.5 nTPM
Eye	85.5 nTPM

Cytotrophoblasts	60.6 nTPM
Placenta	60.6 nTPM

T-cells	57.4 nTPM
Endometrium	119.4 nTPM
Prostate	85.2 nTPM
Skin	76.8 nTPM
Adipose tissue	75.3 nTPM
Lymph node	73.1 nTPM
Skeletal muscle	71.4 nTPM
Stomach	57.0 nTPM
Spleen	55.6 nTPM
Breast	55.4 nTPM
Colon	54.2 nTPM
Esophagus	52.4 nTPM
Bone marrow	43.3 nTPM
Liver	37.8 nTPM
Ovary	37.8 nTPM
PBMC	29.6 nTPM
Lung	28.8 nTPM
Kidney	22.0 nTPM

Undifferentiated cells	20.8 nTPM
Rectum	25.3 nTPM
Colon	18.7 nTPM
Small intestine	18.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC