Single cell type - HMOX2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HMOX2
Gene descriptionⁱ Full gene name according to HGNC.	Heme oxygenase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HMOX2 is part of cluster 31 Spermatids - Spermatogenesis with confidenceⁱ 1
413 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TBC1D21	TBC1 domain family member 21	0.7287	31
PPP1R7	Protein phosphatase 1 regulatory subunit 7	0.7024	34
PSMF1	Proteasome inhibitor subunit 1	0.7019	31
ST6GALNAC2	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	0.6869	31
MSTO1	Misato mitochondrial distribution and morphology regulator 1	0.6721	31
SPANXB1	SPANX family member B1	0.6634	34
MLF1	Myeloid leukemia factor 1	0.6536	31
THBS3	Thrombospondin 3	0.6471	31
ARMC12	Armadillo repeat containing 12	0.6464	34
CCDC188	Coiled-coil domain containing 188	0.6410	31
MTX1	Metaxin 1	0.6363	31
TEX22	Testis expressed 22	0.6225	31
CEP170	Centrosomal protein 170	0.6211	31
EIF5A2	Eukaryotic translation initiation factor 5A2	0.6180	34
KLHDC3	Kelch domain containing 3	0.6175	31

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	33.8 nTPM
Breast	42.0 nTPM
Adipose tissue	25.7 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	41.5 nTPM
Lung	41.5 nTPM

Astrocytes	7.8 nTPM
Brain	7.8 nTPM

B-cells	37.2 nTPM
Liver	63.4 nTPM
Kidney	61.9 nTPM
PBMC	44.2 nTPM
Breast	42.8 nTPM
Spleen	32.2 nTPM
Stomach	29.0 nTPM
Adipose tissue	27.6 nTPM
Colon	25.5 nTPM
Bone marrow	25.3 nTPM
Lymph node	20.2 nTPM

Dendritic cells	59.8 nTPM
Breast	89.7 nTPM
Adipose tissue	69.6 nTPM
PBMC	20.0 nTPM

Endothelial cells	53.4 nTPM
Pancreas	119.6 nTPM
Ovary	103.2 nTPM
Prostate	83.7 nTPM
Placenta	63.6 nTPM
Skin	60.6 nTPM
Testis	44.8 nTPM
Eye	41.2 nTPM
Heart muscle	39.9 nTPM
Liver	39.4 nTPM
Lung	34.3 nTPM
Breast	31.1 nTPM
Esophagus	30.8 nTPM
Skeletal muscle	28.2 nTPM
Endometrium	26.6 nTPM

Fibroblasts	39.4 nTPM
Heart muscle	57.7 nTPM
Placenta	51.1 nTPM
Adipose tissue	49.4 nTPM
Skin	44.0 nTPM
Lung	42.4 nTPM
Ovary	42.1 nTPM
Breast	33.5 nTPM
Stomach	32.7 nTPM
Skeletal muscle	30.0 nTPM
Prostate	26.6 nTPM
Esophagus	23.4 nTPM

Intestinal goblet cells	37.6 nTPM
Colon	44.3 nTPM
Small intestine	40.1 nTPM
Rectum	28.4 nTPM

Macrophages	30.6 nTPM
Pancreas	71.5 nTPM
Kidney	46.8 nTPM
Lung	45.9 nTPM
Testis	40.7 nTPM
Ovary	39.3 nTPM
Breast	34.0 nTPM
PBMC	27.3 nTPM
Prostate	26.3 nTPM
Endometrium	22.9 nTPM
Bone marrow	22.5 nTPM
Esophagus	22.0 nTPM
Adipose tissue	21.3 nTPM
Skeletal muscle	14.0 nTPM
Spleen	12.5 nTPM
Stomach	11.7 nTPM

Paneth cells	70.7 nTPM
Colon	118.6 nTPM
Small intestine	56.3 nTPM
Rectum	37.2 nTPM

Plasma cells	47.1 nTPM
Bone marrow	75.8 nTPM
Spleen	47.5 nTPM
Esophagus	43.0 nTPM
Stomach	37.7 nTPM
Adipose tissue	31.6 nTPM

Respiratory ciliated cells	39.9 nTPM
Bronchus	46.3 nTPM
Lung	33.5 nTPM

Smooth muscle cells	58.0 nTPM
Prostate	87.2 nTPM
Heart muscle	86.7 nTPM
Pancreas	85.8 nTPM
Skeletal muscle	69.5 nTPM
Adipose tissue	68.0 nTPM
Skin	61.7 nTPM
Bronchus	50.8 nTPM
Ovary	42.0 nTPM
Breast	36.6 nTPM
Esophagus	24.8 nTPM
Endometrium	24.6 nTPM

T-cells	88.3 nTPM
Ovary	166.8 nTPM
Kidney	138.3 nTPM
Skin	130.3 nTPM
Liver	123.4 nTPM
Adipose tissue	113.3 nTPM
Bone marrow	101.1 nTPM
PBMC	101.0 nTPM
Stomach	86.1 nTPM
Spleen	76.4 nTPM
Breast	71.5 nTPM
Colon	71.3 nTPM
Esophagus	65.5 nTPM
Lung	59.2 nTPM
Skeletal muscle	58.2 nTPM
Lymph node	57.6 nTPM
Prostate	42.6 nTPM
Endometrium	38.7 nTPM

Basal keratinocytes	54.8 nTPM
Skin	54.8 nTPM

Basal prostatic cells	35.7 nTPM
Prostate	35.7 nTPM

Basal respiratory cells	73.5 nTPM
Bronchus	73.5 nTPM

Basal squamous epithelial cells	19.4 nTPM
Esophagus	19.4 nTPM

Undifferentiated cells	48.9 nTPM
Colon	61.8 nTPM
Small intestine	45.3 nTPM
Rectum	39.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC