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The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
HPA049074
Most of the normal tissues displayed weak to moderate cytoplasmic and nuclear positivity. Strong staining was observed in lung macrophages and red pulp of spleen. The liver, pancreatic islets, kidney, testis, muscles and soft tissues were negative.
HPA054496
Normal tissues showed weak to moderate cytoplasmic staining with membranous and nuclear positivity in few tissues. Lung macrophages and cells in red pulp of spleen displayed strong cytoplasmic positivity. A subset of cells parathyroid displayed strong cytoplasmic and membranous staining. Liver, cells in renal glomeruli, trophoblastic cells, cells in seminiferus ducts and the CNS tissues were negative.
CAB006853
Moderate to strong cytoplasmic, and in some cases also nuclear, positivity was generally seen in normal tissues. Inflammatory cells (especially macrophages) and endothelial cells were strongly stained. Non-neuronal cells in CNS were negative while neuronal cells showed strongly cytoplasmic staining.
CAB015948
Most of the normal tissues displayed moderate cytoplasmic positivity which was occasionally accompanied with nuclear staining. Subset of cells in lymphoid tissues and in bone marrow were strongly stained. Strong cytoplasmic staining was seen in gastrointestinal tract while alveolar cells, hepatocytes, testicular and neuronal cells were negative.