Single cell type - LEPROTL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LEPROTL1
Gene descriptionⁱ Full gene name according to HGNC.	Leptin receptor overlapping transcript like 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (T-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (T-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

LEPROTL1 is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CD40LG	CD40 ligand	0.9223	24
IL7R	Interleukin 7 receptor	0.9223	24
PBX4	PBX homeobox 4	0.9180	24
PDCD1	Programmed cell death 1	0.9177	24
CD28	CD28 molecule	0.9039	24
CCR4	C-C motif chemokine receptor 4	0.8980	24
CTLA4	Cytotoxic T-lymphocyte associated protein 4	0.8951	24
ITK	IL2 inducible T cell kinase	0.8769	24
ICOS	Inducible T cell costimulator	0.8705	24
GPR171	G protein-coupled receptor 171	0.8652	24
TNFSF8	TNF superfamily member 8	0.8614	24
FOXP3	Forkhead box P3	0.8452	24
TRBV28	T cell receptor beta variable 28	0.8196	24
CD96	CD96 molecule	0.8140	24
SPOCK2	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2	0.8113	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	97.7 nTPM
Breast	123.0 nTPM
Adipose tissue	72.5 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	42.3 nTPM
Lung	42.3 nTPM

Astrocytes	13.7 nTPM
Brain	13.7 nTPM

B-cells	62.2 nTPM
Adipose tissue	111.8 nTPM
Stomach	106.3 nTPM
Liver	66.1 nTPM
PBMC	61.4 nTPM
Lymph node	60.6 nTPM
Colon	52.7 nTPM
Kidney	52.4 nTPM
Spleen	41.9 nTPM
Breast	36.0 nTPM
Bone marrow	32.7 nTPM

Dendritic cells	196.6 nTPM
Adipose tissue	338.8 nTPM
Breast	179.3 nTPM
PBMC	71.8 nTPM

Endothelial cells	67.2 nTPM
Placenta	177.9 nTPM
Breast	81.4 nTPM
Pancreas	77.2 nTPM
Liver	76.1 nTPM
Skeletal muscle	72.1 nTPM
Heart muscle	69.4 nTPM
Skin	65.3 nTPM
Eye	64.7 nTPM
Ovary	57.3 nTPM
Endometrium	51.1 nTPM
Esophagus	50.0 nTPM
Testis	41.2 nTPM
Lung	31.2 nTPM
Prostate	26.0 nTPM

Fibroblasts	36.4 nTPM
Stomach	59.4 nTPM
Placenta	54.8 nTPM
Lung	52.5 nTPM
Skin	40.8 nTPM
Breast	37.4 nTPM
Ovary	34.1 nTPM
Esophagus	26.9 nTPM
Heart muscle	26.6 nTPM
Adipose tissue	24.7 nTPM
Skeletal muscle	24.5 nTPM
Prostate	19.0 nTPM

Intestinal goblet cells	35.4 nTPM
Colon	45.0 nTPM
Small intestine	30.7 nTPM
Rectum	30.6 nTPM

Macrophages	85.1 nTPM
Adipose tissue	122.2 nTPM
Kidney	116.5 nTPM
Pancreas	109.7 nTPM
Ovary	108.8 nTPM
Lung	94.4 nTPM
Testis	92.4 nTPM
Bone marrow	91.2 nTPM
Breast	90.0 nTPM
Stomach	88.0 nTPM
Spleen	82.0 nTPM
Esophagus	67.7 nTPM
Skeletal muscle	56.5 nTPM
PBMC	54.6 nTPM
Prostate	53.9 nTPM
Endometrium	48.5 nTPM

Paneth cells	36.7 nTPM
Colon	39.6 nTPM
Small intestine	37.6 nTPM
Rectum	33.1 nTPM

Plasma cells	78.0 nTPM
Adipose tissue	135.4 nTPM
Spleen	75.2 nTPM
Stomach	71.3 nTPM
Esophagus	55.5 nTPM
Bone marrow	52.7 nTPM

Respiratory ciliated cells	65.7 nTPM
Bronchus	93.4 nTPM
Lung	37.9 nTPM

Smooth muscle cells	71.3 nTPM
Bronchus	276.0 nTPM
Ovary	157.7 nTPM
Pancreas	100.2 nTPM
Endometrium	42.5 nTPM
Breast	40.5 nTPM
Heart muscle	39.7 nTPM
Skin	32.1 nTPM
Esophagus	29.4 nTPM
Adipose tissue	23.3 nTPM
Prostate	22.2 nTPM
Skeletal muscle	20.9 nTPM

T-cells	351.9 nTPM
Adipose tissue	944.1 nTPM
Stomach	670.9 nTPM
Skin	629.5 nTPM
Lymph node	438.2 nTPM
Colon	436.2 nTPM
Spleen	409.9 nTPM
Breast	369.5 nTPM
Ovary	367.0 nTPM
PBMC	274.8 nTPM
Skeletal muscle	245.7 nTPM
Bone marrow	227.9 nTPM
Kidney	224.5 nTPM
Endometrium	171.1 nTPM
Prostate	170.4 nTPM
Liver	151.0 nTPM
Lung	147.3 nTPM
Esophagus	104.8 nTPM

Basal keratinocytes	29.2 nTPM
Skin	29.2 nTPM

Basal prostatic cells	16.5 nTPM
Prostate	16.5 nTPM

Basal respiratory cells	57.5 nTPM
Bronchus	57.5 nTPM

Basal squamous epithelial cells	21.1 nTPM
Esophagus	21.1 nTPM

Undifferentiated cells	33.2 nTPM
Colon	40.5 nTPM
Rectum	30.9 nTPM
Small intestine	28.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC