Single cell type - OLFM2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OLFM2
Gene descriptionⁱ Full gene name according to HGNC.	Olfactomedin 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Keratinocytes - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal keratinocytes, Oligodendrocyte precursor cells, Suprabasal keratinocytes, Astrocytes, Muller glia cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AN3-CA, ASC diff, BJ hTERT+, SH-SY5Y, U-2 OS, WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal keratinocytes, Oligodendrocyte precursor cells, Suprabasal keratinocytes, Astrocytes, Muller glia cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OLFM2 is part of cluster 28 Keratinocytes - Keratinization with confidenceⁱ 1
89 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SERPINA12	Serpin family A member 12	0.4832	28
PYGO1	Pygopus family PHD finger 1	0.4774	68
CLEC2A	C-type lectin domain family 2 member A	0.4769	28
CAMSAP2	Calmodulin regulated spectrin associated protein family member 2	0.4712	68
SCRG1	Stimulator of chondrogenesis 1	0.4696	5
HEPHL1	Hephaestin like 1	0.4665	28
PLA2G4E	Phospholipase A2 group IVE	0.4636	28
LCE1A	Late cornified envelope 1A	0.4633	28
CASP14	Caspase 14	0.4627	28
KRT14	Keratin 14	0.4621	28
C1orf68	Chromosome 1 open reading frame 68	0.4600	28
ENHO	Energy homeostasis associated	0.4586	5
LCE5A	Late cornified envelope 5A	0.4516	28
LCE1B	Late cornified envelope 1B	0.4511	28
CCL27	C-C motif chemokine ligand 27	0.4509	28

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.9 nTPM
Breast	21.0 nTPM
Adipose tissue	4.9 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

B-cells	0.3 nTPM
Liver	2.9 nTPM
Spleen	0.3 nTPM
Lymph node	0.2 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Basal prostatic cells	4.7 nTPM
Prostate	4.7 nTPM

Dendritic cells	1.0 nTPM
Breast	2.2 nTPM
Adipose tissue	0.9 nTPM
PBMC	0.0 nTPM

Endothelial cells	4.3 nTPM
Skin	24.0 nTPM
Breast	12.2 nTPM
Eye	8.1 nTPM
Prostate	5.4 nTPM
Esophagus	3.1 nTPM
Testis	3.0 nTPM
Endometrium	1.5 nTPM
Skeletal muscle	1.1 nTPM
Liver	0.9 nTPM
Ovary	0.9 nTPM
Heart muscle	0.4 nTPM
Lung	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	17.2 nTPM
Skin	64.3 nTPM
Breast	35.1 nTPM
Adipose tissue	24.9 nTPM
Prostate	24.2 nTPM
Esophagus	13.2 nTPM
Placenta	8.3 nTPM
Ovary	7.0 nTPM
Stomach	6.0 nTPM
Skeletal muscle	5.5 nTPM
Heart muscle	0.5 nTPM
Lung	0.0 nTPM

Intestinal goblet cells	0.2 nTPM
Rectum	0.6 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Macrophages	0.6 nTPM
Breast	4.2 nTPM
Prostate	3.4 nTPM
Ovary	0.7 nTPM
Testis	0.6 nTPM
Skeletal muscle	0.4 nTPM
Adipose tissue	0.3 nTPM
Kidney	0.0 nTPM
Lung	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Endometrium	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	0.5 nTPM
Bone marrow	1.7 nTPM
Stomach	0.4 nTPM
Spleen	0.3 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	0.2 nTPM
Bronchus	0.4 nTPM
Lung	0.0 nTPM

Smooth muscle cells	24.3 nTPM
Adipose tissue	76.7 nTPM
Skin	54.7 nTPM
Endometrium	31.4 nTPM
Breast	31.0 nTPM
Pancreas	21.7 nTPM
Ovary	21.0 nTPM
Esophagus	12.4 nTPM
Skeletal muscle	9.1 nTPM
Prostate	8.8 nTPM
Heart muscle	0.4 nTPM
Bronchus	0.0 nTPM

T-cells	7.7 nTPM
Kidney	23.3 nTPM
Ovary	17.8 nTPM
Bone marrow	13.8 nTPM
PBMC	12.9 nTPM
Skin	11.9 nTPM
Liver	10.9 nTPM
Lymph node	9.2 nTPM
Spleen	6.6 nTPM
Stomach	6.6 nTPM
Breast	6.4 nTPM
Prostate	4.7 nTPM
Colon	3.8 nTPM
Skeletal muscle	1.8 nTPM
Endometrium	1.2 nTPM
Adipose tissue	0.8 nTPM
Lung	0.0 nTPM
Esophagus	0.0 nTPM

Astrocytes	108.4 nTPM
Brain	108.4 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Cytotrophoblasts	0.1 nTPM
Placenta	0.1 nTPM

Undifferentiated cells	0.1 nTPM
Rectum	0.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC