Single cell type - MIER2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MIER2
Gene descriptionⁱ Full gene name according to HGNC.	MIER family member 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Adipocytes & Endothelial cells - Angiogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MIER2 is part of cluster 14 Adipocytes & Endothelial cells - Angiogenesis with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMEM88	Transmembrane protein 88	0.7117	14
GPIHBP1	Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	0.6988	14
SOCS3	Suppressor of cytokine signaling 3	0.6974	14
C1QTNF9	C1q and TNF related 9	0.6798	14
CLEC14A	C-type lectin domain containing 14A	0.6513	14
FAM110D	Family with sequence similarity 110 member D	0.6496	14
SLC9A3R2	SLC9A3 regulator 2	0.6300	14
TPO	Thyroid peroxidase	0.6297	14
TNFRSF10D	TNF receptor superfamily member 10d	0.6233	14
SEMA3G	Semaphorin 3G	0.6196	14
ADGRL4	Adhesion G protein-coupled receptor L4	0.6169	14
APOLD1	Apolipoprotein L domain containing 1	0.6167	14
FAM107A	Family with sequence similarity 107 member A	0.6145	14
ATOH8	Atonal bHLH transcription factor 8	0.6141	14
CD300LG	CD300 molecule like family member g	0.6105	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	5.4 nTPM
Lung	5.4 nTPM

Astrocytes	4.2 nTPM
Brain	4.2 nTPM

B-cells	5.0 nTPM
Stomach	10.9 nTPM
Colon	8.0 nTPM
Bone marrow	4.9 nTPM
Kidney	4.8 nTPM
PBMC	4.3 nTPM
Breast	4.0 nTPM
Lymph node	3.9 nTPM
Adipose tissue	3.5 nTPM
Spleen	3.1 nTPM
Liver	2.6 nTPM

Basal keratinocytes	11.2 nTPM
Skin	11.2 nTPM

Dendritic cells	3.7 nTPM
Breast	4.3 nTPM
PBMC	4.0 nTPM
Adipose tissue	2.7 nTPM

Endothelial cells	24.1 nTPM
Skeletal muscle	92.8 nTPM
Esophagus	42.0 nTPM
Eye	38.8 nTPM
Breast	29.8 nTPM
Placenta	25.0 nTPM
Ovary	20.3 nTPM
Endometrium	18.1 nTPM
Skin	15.9 nTPM
Liver	15.6 nTPM
Prostate	15.6 nTPM
Pancreas	11.6 nTPM
Testis	9.5 nTPM
Heart muscle	2.0 nTPM
Lung	0.0 nTPM

Fibroblasts	6.9 nTPM
Placenta	19.0 nTPM
Stomach	10.4 nTPM
Ovary	9.4 nTPM
Prostate	5.9 nTPM
Skeletal muscle	5.5 nTPM
Breast	5.2 nTPM
Esophagus	5.0 nTPM
Adipose tissue	4.8 nTPM
Skin	4.3 nTPM
Lung	3.4 nTPM
Heart muscle	3.0 nTPM

Intestinal goblet cells	4.6 nTPM
Rectum	5.3 nTPM
Colon	4.3 nTPM
Small intestine	4.1 nTPM

Macrophages	8.7 nTPM
Stomach	17.6 nTPM
Ovary	13.6 nTPM
Pancreas	12.8 nTPM
Prostate	12.6 nTPM
Bone marrow	12.5 nTPM
Testis	8.8 nTPM
Breast	8.8 nTPM
Adipose tissue	8.2 nTPM
Skeletal muscle	7.6 nTPM
Kidney	6.8 nTPM
Endometrium	6.2 nTPM
Spleen	6.2 nTPM
Esophagus	4.8 nTPM
Lung	4.7 nTPM
PBMC	0.0 nTPM

Paneth cells	5.9 nTPM
Small intestine	7.5 nTPM
Rectum	7.0 nTPM
Colon	3.3 nTPM

Plasma cells	4.5 nTPM
Stomach	8.7 nTPM
Bone marrow	6.6 nTPM
Spleen	4.5 nTPM
Adipose tissue	2.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	5.7 nTPM
Bronchus	8.4 nTPM
Lung	2.9 nTPM

Smooth muscle cells	5.7 nTPM
Pancreas	18.2 nTPM
Ovary	8.2 nTPM
Skeletal muscle	6.6 nTPM
Skin	5.2 nTPM
Endometrium	5.0 nTPM
Prostate	4.7 nTPM
Breast	4.7 nTPM
Esophagus	4.6 nTPM
Adipose tissue	2.7 nTPM
Bronchus	2.0 nTPM
Heart muscle	0.4 nTPM

T-cells	5.5 nTPM
Esophagus	13.1 nTPM
Prostate	9.5 nTPM
Kidney	6.9 nTPM
Liver	6.5 nTPM
Stomach	6.4 nTPM
PBMC	5.9 nTPM
Colon	5.7 nTPM
Skin	5.5 nTPM
Breast	5.5 nTPM
Bone marrow	5.3 nTPM
Lymph node	5.1 nTPM
Spleen	4.6 nTPM
Skeletal muscle	3.3 nTPM
Lung	3.0 nTPM
Endometrium	2.7 nTPM
Adipose tissue	2.7 nTPM
Ovary	2.2 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Cytotrophoblasts	22.3 nTPM
Placenta	22.3 nTPM

Distal tubular cells	1.9 nTPM
Kidney	1.9 nTPM

Undifferentiated cells	4.9 nTPM
Small intestine	5.6 nTPM
Rectum	5.3 nTPM
Colon	3.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC