Single cell type - CUEDC2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CUEDC2
Gene descriptionⁱ Full gene name according to HGNC.	CUE domain containing 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CUEDC2 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TBPL2	TATA-box binding protein like 2	0.9124	10
ZNF90	Zinc finger protein 90	0.8873	10
HNRNPCL1	Heterogeneous nuclear ribonucleoprotein C like 1	0.8724	10
ANP32D	Acidic nuclear phosphoprotein 32 family member D	0.8322	10
DCAF8L2	DDB1 and CUL4 associated factor 8 like 2	0.8244	10
POTEF	POTE ankyrin domain family member F	0.8193	10
PPT2	Palmitoyl-protein thioesterase 2	0.7754	10
UBB	Ubiquitin B	0.7370	10
TMEM60	Transmembrane protein 60	0.7291	10
BAX	BCL2 associated X, apoptosis regulator	0.7227	10
C17orf49	Chromosome 17 open reading frame 49	0.7138	10
ESD	Esterase D	0.7122	10
ZMAT5	Zinc finger matrin-type 5	0.7068	10
POTEE	POTE ankyrin domain family member E	0.7002	10
PSMB6	Proteasome 20S subunit beta 6	0.6960	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	56.6 nTPM
Breast	70.0 nTPM
Adipose tissue	43.3 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	21.9 nTPM
Lung	21.9 nTPM

Astrocytes	10.7 nTPM
Brain	10.7 nTPM

B-cells	36.1 nTPM
Breast	48.1 nTPM
Spleen	46.8 nTPM
Liver	43.2 nTPM
Colon	41.5 nTPM
Bone marrow	40.9 nTPM
Stomach	39.1 nTPM
PBMC	32.9 nTPM
Lymph node	30.9 nTPM
Kidney	23.8 nTPM
Adipose tissue	14.1 nTPM

Dendritic cells	40.6 nTPM
PBMC	59.8 nTPM
Breast	37.9 nTPM
Adipose tissue	24.1 nTPM

Endothelial cells	46.4 nTPM
Placenta	69.9 nTPM
Breast	61.9 nTPM
Ovary	59.9 nTPM
Liver	56.8 nTPM
Testis	55.1 nTPM
Skin	49.5 nTPM
Pancreas	46.4 nTPM
Esophagus	43.7 nTPM
Eye	41.2 nTPM
Endometrium	41.1 nTPM
Prostate	35.4 nTPM
Skeletal muscle	34.9 nTPM
Heart muscle	31.4 nTPM
Lung	21.8 nTPM

Fibroblasts	58.5 nTPM
Ovary	114.1 nTPM
Placenta	76.7 nTPM
Breast	68.4 nTPM
Esophagus	66.7 nTPM
Adipose tissue	65.3 nTPM
Skin	63.1 nTPM
Stomach	57.9 nTPM
Skeletal muscle	43.7 nTPM
Prostate	38.5 nTPM
Heart muscle	36.8 nTPM
Lung	12.3 nTPM

Intestinal goblet cells	36.4 nTPM
Small intestine	37.9 nTPM
Colon	36.4 nTPM
Rectum	35.0 nTPM

Macrophages	44.3 nTPM
Kidney	68.1 nTPM
Pancreas	61.2 nTPM
Ovary	56.8 nTPM
Stomach	52.7 nTPM
Testis	51.2 nTPM
Bone marrow	51.2 nTPM
Spleen	47.7 nTPM
Breast	47.2 nTPM
Prostate	44.7 nTPM
Esophagus	39.3 nTPM
Adipose tissue	38.0 nTPM
Skeletal muscle	35.5 nTPM
Endometrium	31.1 nTPM
Lung	26.6 nTPM
PBMC	13.6 nTPM

Paneth cells	32.0 nTPM
Rectum	39.2 nTPM
Small intestine	33.8 nTPM
Colon	23.1 nTPM

Plasma cells	45.4 nTPM
Stomach	65.7 nTPM
Esophagus	55.5 nTPM
Spleen	43.5 nTPM
Bone marrow	39.5 nTPM
Adipose tissue	22.5 nTPM

Respiratory ciliated cells	28.1 nTPM
Bronchus	34.4 nTPM
Lung	21.9 nTPM

Smooth muscle cells	164.9 nTPM
Bronchus	1132.9 nTPM
Ovary	120.4 nTPM
Pancreas	79.3 nTPM
Esophagus	77.6 nTPM
Breast	76.7 nTPM
Prostate	65.7 nTPM
Skin	63.4 nTPM
Heart muscle	59.4 nTPM
Endometrium	50.5 nTPM
Adipose tissue	45.7 nTPM
Skeletal muscle	42.1 nTPM

T-cells	38.7 nTPM
Ovary	57.8 nTPM
Kidney	57.5 nTPM
Spleen	51.0 nTPM
Stomach	47.7 nTPM
Bone marrow	46.5 nTPM
Liver	43.8 nTPM
PBMC	43.1 nTPM
Prostate	42.6 nTPM
Lymph node	39.1 nTPM
Skin	36.4 nTPM
Colon	35.6 nTPM
Breast	34.1 nTPM
Esophagus	26.2 nTPM
Lung	25.8 nTPM
Skeletal muscle	24.9 nTPM
Endometrium	23.3 nTPM
Adipose tissue	22.5 nTPM

Basal keratinocytes	31.7 nTPM
Skin	31.7 nTPM

Basal prostatic cells	49.0 nTPM
Prostate	49.0 nTPM

Basal respiratory cells	73.1 nTPM
Bronchus	73.1 nTPM

Basal squamous epithelial cells	44.9 nTPM
Esophagus	44.9 nTPM

Undifferentiated cells	39.3 nTPM
Small intestine	41.7 nTPM
Rectum	39.1 nTPM
Colon	37.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC