Single cell type - UBTF - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBTF
Gene descriptionⁱ Full gene name according to HGNC.	Upstream binding transcription factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UBTF is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FTSJ3	FtsJ RNA 2'-O-methyltransferase 3	0.6110	10
CTCF	CCCTC-binding factor	0.5718	10
PCDHGB2	Protocadherin gamma subfamily B, 2	0.5707	50
BAZ1B	Bromodomain adjacent to zinc finger domain 1B	0.5516	10
CHD4	Chromodomain helicase DNA binding protein 4	0.5319	10
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.5282	10
RP9	RP9 pre-mRNA splicing factor	0.5205	57
PURA	Purine rich element binding protein A	0.5085	10
PCDHGB3	Protocadherin gamma subfamily B, 3	0.4942	43
UTP14A	UTP14A small subunit processome component	0.4708	39
WNT5A	Wnt family member 5A	0.4708	36
GDF11	Growth differentiation factor 11	0.4658	56
C12orf43	Chromosome 12 open reading frame 43	0.4580	63
REST	RE1 silencing transcription factor	0.4576	44
RBM28	RNA binding motif protein 28	0.4575	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	41.4 nTPM
Breast	43.1 nTPM
Adipose tissue	39.6 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	42.1 nTPM
Lung	42.1 nTPM

Astrocytes	14.7 nTPM
Brain	14.7 nTPM

B-cells	57.5 nTPM
Bone marrow	80.1 nTPM
Lymph node	74.9 nTPM
PBMC	68.5 nTPM
Spleen	67.9 nTPM
Stomach	59.0 nTPM
Kidney	52.4 nTPM
Adipose tissue	51.6 nTPM
Liver	48.1 nTPM
Breast	37.5 nTPM
Colon	35.1 nTPM

Dendritic cells	60.3 nTPM
Adipose tissue	76.1 nTPM
Breast	56.9 nTPM
PBMC	47.8 nTPM

Endothelial cells	42.7 nTPM
Endometrium	70.2 nTPM
Lung	59.3 nTPM
Ovary	58.0 nTPM
Heart muscle	57.1 nTPM
Eye	55.0 nTPM
Testis	48.0 nTPM
Esophagus	41.8 nTPM
Skeletal muscle	40.5 nTPM
Breast	34.9 nTPM
Placenta	33.5 nTPM
Liver	29.3 nTPM
Pancreas	27.0 nTPM
Skin	26.5 nTPM
Prostate	16.2 nTPM

Fibroblasts	38.9 nTPM
Lung	61.4 nTPM
Ovary	53.9 nTPM
Heart muscle	53.6 nTPM
Adipose tissue	50.4 nTPM
Skeletal muscle	41.1 nTPM
Breast	40.7 nTPM
Esophagus	30.9 nTPM
Stomach	28.2 nTPM
Placenta	26.5 nTPM
Skin	25.4 nTPM
Prostate	15.4 nTPM

Intestinal goblet cells	32.5 nTPM
Colon	43.6 nTPM
Rectum	30.7 nTPM
Small intestine	23.1 nTPM

Macrophages	27.4 nTPM
Endometrium	44.7 nTPM
Pancreas	43.4 nTPM
Ovary	42.7 nTPM
Lung	41.7 nTPM
Breast	41.0 nTPM
Esophagus	31.5 nTPM
Bone marrow	30.0 nTPM
Skeletal muscle	28.2 nTPM
Adipose tissue	27.5 nTPM
Kidney	18.9 nTPM
Stomach	17.6 nTPM
Testis	16.3 nTPM
Prostate	13.8 nTPM
Spleen	13.5 nTPM
PBMC	0.0 nTPM

Paneth cells	30.7 nTPM
Rectum	32.3 nTPM
Small intestine	30.0 nTPM
Colon	29.6 nTPM

Plasma cells	42.2 nTPM
Bone marrow	56.0 nTPM
Spleen	52.8 nTPM
Adipose tissue	50.3 nTPM
Stomach	27.1 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	26.5 nTPM
Lung	36.5 nTPM
Bronchus	16.6 nTPM

Smooth muscle cells	45.9 nTPM
Heart muscle	80.6 nTPM
Endometrium	58.6 nTPM
Bronchus	58.1 nTPM
Ovary	53.3 nTPM
Breast	50.9 nTPM
Pancreas	40.4 nTPM
Adipose tissue	35.7 nTPM
Esophagus	35.7 nTPM
Skin	35.6 nTPM
Skeletal muscle	33.7 nTPM
Prostate	22.6 nTPM

T-cells	53.1 nTPM
PBMC	70.3 nTPM
Skeletal muscle	67.4 nTPM
Lung	66.8 nTPM
Endometrium	66.8 nTPM
Lymph node	66.0 nTPM
Breast	63.3 nTPM
Adipose tissue	61.7 nTPM
Stomach	58.7 nTPM
Bone marrow	58.2 nTPM
Spleen	50.6 nTPM
Kidney	49.3 nTPM
Ovary	48.9 nTPM
Esophagus	45.9 nTPM
Liver	42.5 nTPM
Colon	39.9 nTPM
Skin	27.6 nTPM
Prostate	19.0 nTPM

Basal keratinocytes	20.5 nTPM
Skin	20.5 nTPM

Basal prostatic cells	19.6 nTPM
Prostate	19.6 nTPM

Basal respiratory cells	17.9 nTPM
Bronchus	17.9 nTPM

Cholangiocytes	35.8 nTPM
Liver	35.8 nTPM

Undifferentiated cells	32.8 nTPM
Rectum	34.2 nTPM
Colon	33.1 nTPM
Small intestine	31.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC