Single cell type - KPNB1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KPNB1
Gene descriptionⁱ Full gene name according to HGNC.	Karyopherin subunit beta 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KPNB1 is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 1
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CPSF2	Cleavage and polyadenylation specific factor 2	0.6046	10
KHDRBS1	KH RNA binding domain containing, signal transduction associated 1	0.5680	59
DKC1	Dyskerin pseudouridine synthase 1	0.5598	39
ILF3	Interleukin enhancer binding factor 3	0.5592	39
SF3B3	Splicing factor 3b subunit 3	0.5486	59
HCFC1	Host cell factor C1	0.5462	10
MED1	Mediator complex subunit 1	0.5396	10
INCENP	Inner centromere protein	0.5246	12
POLR1A	RNA polymerase I subunit A	0.5196	59
HMGN2	High mobility group nucleosomal binding domain 2	0.5145	12
BCCIP	BRCA2 and CDKN1A interacting protein	0.5081	10
OR2D3	Olfactory receptor family 2 subfamily D member 3	0.5043	55
DESI2	Desumoylating isopeptidase 2	0.4998	66
IGHV2-70	Immunoglobulin heavy variable 2-70	0.4998	55
IGLV4-3	Immunoglobulin lambda variable 4-3	0.4972	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	76.8 nTPM
Adipose tissue	82.8 nTPM
Breast	70.9 nTPM

Alveolar cells type 1	128.2 nTPM
Lung	128.2 nTPM

Alveolar cells type 2	71.9 nTPM
Lung	71.9 nTPM

Astrocytes	42.7 nTPM
Brain	42.7 nTPM

B-cells	138.3 nTPM
Lymph node	218.8 nTPM
Stomach	183.0 nTPM
Spleen	174.5 nTPM
Colon	151.8 nTPM
Liver	150.8 nTPM
Bone marrow	148.0 nTPM
Adipose tissue	120.4 nTPM
PBMC	94.3 nTPM
Kidney	80.9 nTPM
Breast	60.2 nTPM

Basal squamous epithelial cells	165.0 nTPM
Esophagus	165.0 nTPM

Dendritic cells	93.9 nTPM
Adipose tissue	109.2 nTPM
PBMC	87.6 nTPM
Breast	84.9 nTPM

Endothelial cells	110.5 nTPM
Liver	188.9 nTPM
Prostate	155.0 nTPM
Ovary	140.5 nTPM
Endometrium	121.0 nTPM
Pancreas	115.9 nTPM
Testis	113.2 nTPM
Placenta	112.0 nTPM
Esophagus	108.8 nTPM
Breast	93.0 nTPM
Lung	90.5 nTPM
Skeletal muscle	86.4 nTPM
Skin	81.1 nTPM
Eye	80.9 nTPM
Heart muscle	60.5 nTPM

Enteroendocrine cells	123.8 nTPM
Colon	145.7 nTPM
Rectum	102.0 nTPM

Erythroid cells	148.7 nTPM
Bone marrow	211.8 nTPM
Liver	85.5 nTPM

Fibroblasts	102.9 nTPM
Ovary	205.6 nTPM
Placenta	117.8 nTPM
Prostate	104.3 nTPM
Esophagus	104.2 nTPM
Lung	98.3 nTPM
Heart muscle	94.8 nTPM
Skin	92.3 nTPM
Skeletal muscle	91.5 nTPM
Adipose tissue	80.6 nTPM
Breast	72.9 nTPM
Stomach	69.8 nTPM

Intestinal goblet cells	82.2 nTPM
Rectum	85.2 nTPM
Colon	82.2 nTPM
Small intestine	79.2 nTPM

Macrophages	102.7 nTPM
Pancreas	158.2 nTPM
Esophagus	154.2 nTPM
Bone marrow	131.2 nTPM
Spleen	123.4 nTPM
Testis	122.5 nTPM
Lung	105.8 nTPM
Ovary	102.1 nTPM
Adipose tissue	101.7 nTPM
Endometrium	96.0 nTPM
Stomach	93.7 nTPM
Breast	88.5 nTPM
Skeletal muscle	88.1 nTPM
Prostate	84.8 nTPM
Kidney	77.1 nTPM
PBMC	13.6 nTPM

Paneth cells	69.8 nTPM
Rectum	76.3 nTPM
Colon	69.2 nTPM
Small intestine	63.8 nTPM

Plasma cells	163.4 nTPM
Spleen	249.0 nTPM
Bone marrow	207.7 nTPM
Stomach	155.8 nTPM
Adipose tissue	112.3 nTPM
Esophagus	92.4 nTPM

Cholangiocytes	88.6 nTPM
Liver	88.6 nTPM

Collecting duct cells	44.1 nTPM
Kidney	44.1 nTPM

Cone photoreceptor cells	68.8 nTPM
Eye	68.8 nTPM

Cytotrophoblasts	132.7 nTPM
Placenta	132.7 nTPM

Respiratory ciliated cells	60.6 nTPM
Bronchus	64.4 nTPM
Lung	56.9 nTPM

Smooth muscle cells	104.6 nTPM
Pancreas	215.9 nTPM
Ovary	173.8 nTPM
Esophagus	121.0 nTPM
Endometrium	101.2 nTPM
Prostate	97.3 nTPM
Skeletal muscle	93.5 nTPM
Adipose tissue	82.2 nTPM
Skin	78.4 nTPM
Heart muscle	75.7 nTPM
Breast	61.1 nTPM
Bronchus	50.0 nTPM

T-cells	108.1 nTPM
Lymph node	177.7 nTPM
Bone marrow	150.2 nTPM
Spleen	139.1 nTPM
Colon	124.9 nTPM
Stomach	122.7 nTPM
Skeletal muscle	120.1 nTPM
PBMC	116.7 nTPM
Liver	115.6 nTPM
Adipose tissue	112.4 nTPM
Esophagus	111.4 nTPM
Kidney	99.2 nTPM
Endometrium	98.4 nTPM
Skin	89.3 nTPM
Lung	77.5 nTPM
Breast	71.8 nTPM
Ovary	57.8 nTPM
Prostate	52.1 nTPM

Undifferentiated cells	128.4 nTPM
Colon	170.3 nTPM
Small intestine	116.3 nTPM
Rectum	98.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC