Single cell type - MLX - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MLX
Gene descriptionⁱ Full gene name according to HGNC.	MAX dimerization protein MLX
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Enterocytes - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MLX is part of cluster 45 Enterocytes - Digestion with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PLIN3	Perilipin 3	0.5760	53
PPCDC	Phosphopantothenoylcysteine decarboxylase	0.5394	55
ZBTB7B	Zinc finger and BTB domain containing 7B	0.5245	45
SULT1A1	Sulfotransferase family 1A member 1	0.5189	45
CIDEC	Cell death inducing DFFA like effector c	0.5076	45
ABCG2	ATP binding cassette subfamily G member 2 (Junior blood group)	0.5049	45
TMEM236	Transmembrane protein 236	0.5041	45
SULT1A2	Sulfotransferase family 1A member 2	0.5040	45
CASP5	Caspase 5	0.5029	53
GFER	Growth factor, augmenter of liver regeneration	0.4865	45
APOA4	Apolipoprotein A4	0.4823	45
C11orf86	Chromosome 11 open reading frame 86	0.4795	45
SLC51A	Solute carrier family 51 subunit alpha	0.4791	45
C1orf210	Chromosome 1 open reading frame 210	0.4754	53
NAAA	N-acylethanolamine acid amidase	0.4752	45

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	31.6 nTPM
Breast	33.9 nTPM
Adipose tissue	29.4 nTPM

Alveolar cells type 1	67.3 nTPM
Lung	67.3 nTPM

Alveolar cells type 2	69.8 nTPM
Lung	69.8 nTPM

Astrocytes	9.4 nTPM
Brain	9.4 nTPM

B-cells	35.6 nTPM
Liver	59.7 nTPM
PBMC	52.9 nTPM
Breast	41.5 nTPM
Spleen	35.7 nTPM
Colon	35.1 nTPM
Lymph node	28.7 nTPM
Kidney	28.5 nTPM
Stomach	25.5 nTPM
Bone marrow	25.3 nTPM
Adipose tissue	23.1 nTPM

Dendritic cells	35.8 nTPM
Breast	44.1 nTPM
Adipose tissue	39.2 nTPM
PBMC	23.9 nTPM

Endothelial cells	28.2 nTPM
Skin	39.0 nTPM
Esophagus	37.1 nTPM
Ovary	34.6 nTPM
Placenta	31.3 nTPM
Lung	31.2 nTPM
Breast	30.0 nTPM
Skeletal muscle	29.7 nTPM
Testis	28.2 nTPM
Prostate	26.8 nTPM
Endometrium	23.6 nTPM
Eye	23.5 nTPM
Pancreas	23.1 nTPM
Liver	22.9 nTPM
Heart muscle	13.5 nTPM

Fibroblasts	26.0 nTPM
Lung	41.3 nTPM
Stomach	34.1 nTPM
Placenta	31.8 nTPM
Skin	30.3 nTPM
Adipose tissue	28.6 nTPM
Esophagus	26.1 nTPM
Breast	25.2 nTPM
Ovary	23.3 nTPM
Skeletal muscle	21.8 nTPM
Prostate	16.7 nTPM
Heart muscle	6.6 nTPM

Intestinal goblet cells	46.9 nTPM
Small intestine	63.0 nTPM
Colon	42.9 nTPM
Rectum	34.8 nTPM

Macrophages	59.5 nTPM
Pancreas	97.0 nTPM
Lung	83.3 nTPM
Bone marrow	82.5 nTPM
Testis	70.3 nTPM
Ovary	69.9 nTPM
Adipose tissue	67.9 nTPM
Stomach	67.4 nTPM
Prostate	63.0 nTPM
Spleen	62.2 nTPM
Kidney	61.3 nTPM
Esophagus	48.7 nTPM
Breast	41.5 nTPM
Endometrium	39.3 nTPM
Skeletal muscle	38.6 nTPM
PBMC	0.0 nTPM

Paneth cells	86.4 nTPM
Colon	135.1 nTPM
Rectum	67.9 nTPM
Small intestine	56.3 nTPM

Plasma cells	61.8 nTPM
Bone marrow	98.9 nTPM
Spleen	71.5 nTPM
Esophagus	67.8 nTPM
Stomach	40.2 nTPM
Adipose tissue	30.3 nTPM

Respiratory ciliated cells	30.4 nTPM
Lung	33.5 nTPM
Bronchus	27.3 nTPM

Smooth muscle cells	31.4 nTPM
Pancreas	74.2 nTPM
Skin	38.8 nTPM
Esophagus	34.1 nTPM
Breast	34.1 nTPM
Skeletal muscle	30.5 nTPM
Prostate	28.8 nTPM
Ovary	27.0 nTPM
Endometrium	23.6 nTPM
Adipose tissue	23.0 nTPM
Heart muscle	19.4 nTPM
Bronchus	12.3 nTPM

T-cells	38.3 nTPM
PBMC	54.8 nTPM
Bone marrow	52.2 nTPM
Lung	51.6 nTPM
Skin	50.6 nTPM
Liver	43.7 nTPM
Kidney	43.1 nTPM
Ovary	42.2 nTPM
Colon	39.0 nTPM
Stomach	38.6 nTPM
Skeletal muscle	37.3 nTPM
Breast	36.4 nTPM
Spleen	36.0 nTPM
Lymph node	33.5 nTPM
Adipose tissue	32.9 nTPM
Prostate	23.6 nTPM
Endometrium	22.1 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	41.9 nTPM
Skin	41.9 nTPM

Basal prostatic cells	28.1 nTPM
Prostate	28.1 nTPM

Basal squamous epithelial cells	33.0 nTPM
Esophagus	33.0 nTPM

Cholangiocytes	40.0 nTPM
Liver	40.0 nTPM

Undifferentiated cells	54.2 nTPM
Colon	62.9 nTPM
Small intestine	55.3 nTPM
Rectum	44.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC