Single cell type - SMURF2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SMURF2
Gene descriptionⁱ Full gene name according to HGNC.	SMAD specific E3 ubiquitin protein ligase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BJ, HBF TERT88, LHCN-M2, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SMURF2 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MED13	Mediator complex subunit 13	0.5218	44
COL12A1	Collagen type XII alpha 1 chain	0.5006	50
PLXDC2	Plexin domain containing 2	0.4978	50
FAP	Fibroblast activation protein alpha	0.4938	50
SMIM33	Small integral membrane protein 33	0.4867	7
PAXBP1	PAX3 and PAX7 binding protein 1	0.4863	52
EPC2	Enhancer of polycomb homolog 2	0.4828	44
SSC5D	Scavenger receptor cysteine rich family member with 5 domains	0.4802	50
ADGRG2	Adhesion G protein-coupled receptor G2	0.4794	50
RGPD5	RANBP2 like and GRIP domain containing 5	0.4764	52
DYRK1A	Dual specificity tyrosine phosphorylation regulated kinase 1A	0.4759	44
GCNA	Germ cell nuclear acidic peptidase	0.4694	7
N4BP1	NEDD4 binding protein 1	0.4666	44
APCDD1L	APC down-regulated 1 like	0.4643	50
BPTF	Bromodomain PHD finger transcription factor	0.4634	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	40.2 nTPM
Adipose tissue	53.1 nTPM
Breast	27.4 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	26.0 nTPM
Lung	26.0 nTPM

Astrocytes	96.3 nTPM
Brain	96.3 nTPM

B-cells	18.6 nTPM
Adipose tissue	36.0 nTPM
Lymph node	27.6 nTPM
Colon	19.2 nTPM
Breast	17.3 nTPM
Stomach	17.2 nTPM
PBMC	17.1 nTPM
Spleen	15.6 nTPM
Kidney	14.3 nTPM
Bone marrow	12.3 nTPM
Liver	9.0 nTPM

Dendritic cells	35.4 nTPM
Adipose tissue	50.4 nTPM
Breast	39.8 nTPM
PBMC	16.0 nTPM

Endothelial cells	39.3 nTPM
Endometrium	113.5 nTPM
Lung	77.9 nTPM
Ovary	56.8 nTPM
Skeletal muscle	42.8 nTPM
Prostate	36.5 nTPM
Esophagus	35.7 nTPM
Liver	32.1 nTPM
Breast	28.3 nTPM
Testis	26.9 nTPM
Skin	26.7 nTPM
Placenta	22.7 nTPM
Eye	21.8 nTPM
Heart muscle	17.2 nTPM
Pancreas	11.6 nTPM

Fibroblasts	28.1 nTPM
Skeletal muscle	59.7 nTPM
Adipose tissue	46.5 nTPM
Skin	40.3 nTPM
Lung	25.7 nTPM
Prostate	23.2 nTPM
Heart muscle	23.0 nTPM
Stomach	20.8 nTPM
Breast	19.6 nTPM
Esophagus	19.1 nTPM
Placenta	18.5 nTPM
Ovary	12.8 nTPM

Intestinal goblet cells	11.2 nTPM
Small intestine	13.0 nTPM
Rectum	10.5 nTPM
Colon	10.0 nTPM

Macrophages	22.8 nTPM
Breast	56.7 nTPM
Adipose tissue	38.5 nTPM
Skeletal muscle	31.2 nTPM
Endometrium	29.4 nTPM
Esophagus	28.3 nTPM
Prostate	26.3 nTPM
Lung	22.2 nTPM
Spleen	21.8 nTPM
Ovary	19.9 nTPM
Kidney	16.6 nTPM
Testis	14.0 nTPM
PBMC	13.6 nTPM
Pancreas	12.8 nTPM
Bone marrow	7.5 nTPM
Stomach	2.9 nTPM

Paneth cells	24.7 nTPM
Small intestine	37.6 nTPM
Colon	19.7 nTPM
Rectum	16.8 nTPM

Plasma cells	18.0 nTPM
Adipose tissue	66.5 nTPM
Spleen	7.2 nTPM
Stomach	6.9 nTPM
Esophagus	6.1 nTPM
Bone marrow	3.3 nTPM

Respiratory ciliated cells	14.4 nTPM
Lung	14.6 nTPM
Bronchus	14.2 nTPM

Smooth muscle cells	23.3 nTPM
Pancreas	46.3 nTPM
Endometrium	32.3 nTPM
Ovary	30.7 nTPM
Adipose tissue	24.2 nTPM
Heart muscle	22.3 nTPM
Skin	22.0 nTPM
Prostate	19.1 nTPM
Skeletal muscle	17.8 nTPM
Breast	17.1 nTPM
Esophagus	14.0 nTPM
Bronchus	10.4 nTPM

T-cells	33.5 nTPM
Breast	73.3 nTPM
Adipose tissue	65.7 nTPM
Endometrium	58.5 nTPM
Skeletal muscle	46.3 nTPM
Colon	37.6 nTPM
Lung	36.5 nTPM
Stomach	31.7 nTPM
Skin	30.4 nTPM
Lymph node	29.5 nTPM
Liver	26.3 nTPM
Esophagus	26.2 nTPM
Ovary	20.1 nTPM
PBMC	19.1 nTPM
Prostate	19.0 nTPM
Spleen	18.8 nTPM
Bone marrow	16.8 nTPM
Kidney	13.7 nTPM

Basal keratinocytes	43.8 nTPM
Skin	43.8 nTPM

Basal prostatic cells	30.8 nTPM
Prostate	30.8 nTPM

Basal squamous epithelial cells	25.0 nTPM
Esophagus	25.0 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Undifferentiated cells	13.8 nTPM
Small intestine	15.9 nTPM
Colon	13.9 nTPM
Rectum	11.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC