Single cell type - ALDOC - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ALDOC
Gene descriptionⁱ Full gene name according to HGNC.	Aldolase, fructose-bisphosphate C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Candidate cardiovascular disease genes Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Photoreceptor cells - Phototransduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Rod photoreceptor cells, Horizontal cells, Muller glia cells, Proximal enterocytes, Bipolar cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RPMI-8226, U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells, Horizontal cells, Muller glia cells, Proximal enterocytes, Bipolar cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ALDOC is part of cluster 46 Photoreceptor cells - Phototransduction with confidenceⁱ 1
209 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ENO2	Enolase 2	0.7483	46
RCVRN	Recoverin	0.6716	46
PDE6G	Phosphodiesterase 6G	0.6671	46
GNGT1	G protein subunit gamma transducin 1	0.6670	46
RHO	Rhodopsin	0.6664	46
GNB1	G protein subunit beta 1	0.6618	46
NRL	Neural retina leucine zipper	0.6606	46
CNGA1	Cyclic nucleotide gated channel subunit alpha 1	0.6582	46
CLUL1	Clusterin like 1	0.6547	46
GNAT1	G protein subunit alpha transducin 1	0.6533	46
ELOVL4	ELOVL fatty acid elongase 4	0.6487	46
ROM1	Retinal outer segment membrane protein 1	0.6484	46
AIPL1	Aryl hydrocarbon receptor interacting protein like 1	0.6445	46
PRCD	Photoreceptor disc component	0.6437	46
SAG	S-antigen visual arrestin	0.6432	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	4.2 nTPM
Breast	5.3 nTPM
Adipose tissue	2.9 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	15.8 nTPM
Lung	15.8 nTPM

Astrocytes	97.6 nTPM
Brain	97.6 nTPM

B-cells	9.8 nTPM
Colon	14.4 nTPM
PBMC	12.9 nTPM
Liver	11.4 nTPM
Spleen	11.1 nTPM
Breast	10.7 nTPM
Kidney	9.5 nTPM
Bone marrow	9.0 nTPM
Lymph node	7.8 nTPM
Stomach	6.8 nTPM
Adipose tissue	4.0 nTPM

Dendritic cells	9.5 nTPM
PBMC	12.0 nTPM
Adipose tissue	10.0 nTPM
Breast	6.5 nTPM

Endothelial cells	11.3 nTPM
Eye	46.9 nTPM
Testis	33.5 nTPM
Liver	14.7 nTPM
Prostate	10.5 nTPM
Placenta	9.1 nTPM
Skin	8.0 nTPM
Pancreas	7.7 nTPM
Breast	6.4 nTPM
Esophagus	5.6 nTPM
Skeletal muscle	5.3 nTPM
Heart muscle	4.3 nTPM
Ovary	3.2 nTPM
Endometrium	2.5 nTPM
Lung	0.0 nTPM

Fibroblasts	5.8 nTPM
Placenta	11.2 nTPM
Esophagus	10.8 nTPM
Prostate	10.1 nTPM
Skin	10.1 nTPM
Heart muscle	6.9 nTPM
Breast	4.7 nTPM
Ovary	3.6 nTPM
Skeletal muscle	3.0 nTPM
Adipose tissue	2.3 nTPM
Lung	1.2 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	12.9 nTPM
Small intestine	23.9 nTPM
Colon	9.3 nTPM
Rectum	5.5 nTPM

Macrophages	3.1 nTPM
Prostate	8.1 nTPM
Breast	5.4 nTPM
Kidney	5.3 nTPM
Esophagus	4.8 nTPM
Spleen	4.2 nTPM
Adipose tissue	3.6 nTPM
Ovary	3.0 nTPM
Testis	2.9 nTPM
Skeletal muscle	2.7 nTPM
Lung	2.5 nTPM
Bone marrow	2.5 nTPM
Endometrium	2.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	12.4 nTPM
Colon	19.7 nTPM
Small intestine	15.0 nTPM
Rectum	2.4 nTPM

Plasma cells	2.6 nTPM
Adipose tissue	5.2 nTPM
Stomach	3.6 nTPM
Spleen	2.6 nTPM
Bone marrow	1.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	11.8 nTPM
Bronchus	23.7 nTPM
Lung	0.0 nTPM

Smooth muscle cells	10.1 nTPM
Skin	21.3 nTPM
Pancreas	21.2 nTPM
Skeletal muscle	12.3 nTPM
Prostate	11.2 nTPM
Esophagus	10.9 nTPM
Breast	10.7 nTPM
Bronchus	8.6 nTPM
Heart muscle	5.8 nTPM
Adipose tissue	4.5 nTPM
Ovary	2.9 nTPM
Endometrium	1.8 nTPM

T-cells	17.0 nTPM
Endometrium	44.9 nTPM
Prostate	33.1 nTPM
Colon	23.7 nTPM
Skin	22.1 nTPM
Liver	20.6 nTPM
PBMC	17.5 nTPM
Kidney	15.8 nTPM
Breast	15.0 nTPM
Lymph node	14.2 nTPM
Lung	13.6 nTPM
Spleen	13.6 nTPM
Esophagus	13.1 nTPM
Stomach	12.4 nTPM
Adipose tissue	10.3 nTPM
Bone marrow	9.7 nTPM
Skeletal muscle	8.7 nTPM
Ovary	0.0 nTPM

Basal keratinocytes	7.5 nTPM
Skin	7.5 nTPM

Basal prostatic cells	20.3 nTPM
Prostate	20.3 nTPM

Basal respiratory cells	80.5 nTPM
Bronchus	80.5 nTPM

Cholangiocytes	11.5 nTPM
Liver	11.5 nTPM

Undifferentiated cells	5.1 nTPM
Small intestine	8.3 nTPM
Colon	3.9 nTPM
Rectum	3.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC