Single cell type - VWA5A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	VWA5A
Gene descriptionⁱ Full gene name according to HGNC.	Von Willebrand factor A domain containing 5A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulocytes - Receptor signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (granulocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2, HEL, HHSteC, HUVEC TERT2, RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (granulocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

VWA5A is part of cluster 60 Granulocytes - Receptor signaling with confidenceⁱ 1
79 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CMA1	Chymase 1	0.8930	60
RGS13	Regulator of G protein signaling 13	0.8909	60
CTSG	Cathepsin G	0.8865	60
TPSB2	Tryptase beta 2	0.8863	60
MS4A2	Membrane spanning 4-domains A2	0.8847	60
AC107959.5	Novel protein	0.8843	60
TPSD1	Tryptase delta 1	0.8841	60
GCSAML	Germinal center associated signaling and motility like	0.8841	60
CPA3	Carboxypeptidase A3	0.8831	60
MAS1L	MAS1 proto-oncogene like, G protein-coupled receptor	0.8831	60
HDC	Histidine decarboxylase	0.8826	60
AP000781.2	Novel protein	0.8716	60
TPSAB1	Tryptase alpha/beta 1	0.8693	60
WASH6P	WASP family homolog 6, pseudogene	0.8638	60
OR14J1	Olfactory receptor family 14 subfamily J member 1	0.8597	60

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	5.0 nTPM
Adipose tissue	6.5 nTPM
Breast	3.4 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	28.3 nTPM
Lung	28.3 nTPM

Astrocytes	4.6 nTPM
Brain	4.6 nTPM

B-cells	1.3 nTPM
Liver	3.3 nTPM
PBMC	2.8 nTPM
Adipose tissue	2.5 nTPM
Colon	1.6 nTPM
Lymph node	1.0 nTPM
Bone marrow	0.8 nTPM
Spleen	0.7 nTPM
Kidney	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	2.0 nTPM
Breast	3.3 nTPM
Adipose tissue	2.7 nTPM
PBMC	0.0 nTPM

Endothelial cells	4.3 nTPM
Lung	12.5 nTPM
Skin	11.3 nTPM
Esophagus	7.8 nTPM
Breast	5.0 nTPM
Skeletal muscle	4.8 nTPM
Placenta	4.0 nTPM
Testis	3.8 nTPM
Prostate	2.7 nTPM
Heart muscle	2.6 nTPM
Endometrium	1.9 nTPM
Liver	1.8 nTPM
Ovary	1.7 nTPM
Eye	0.8 nTPM
Pancreas	0.0 nTPM

Fibroblasts	11.4 nTPM
Esophagus	27.8 nTPM
Skin	22.3 nTPM
Lung	14.5 nTPM
Skeletal muscle	11.9 nTPM
Stomach	11.9 nTPM
Adipose tissue	11.5 nTPM
Prostate	8.9 nTPM
Breast	7.1 nTPM
Heart muscle	6.7 nTPM
Ovary	1.9 nTPM
Placenta	1.5 nTPM

Intestinal goblet cells	22.3 nTPM
Small intestine	27.0 nTPM
Rectum	24.9 nTPM
Colon	15.0 nTPM

Macrophages	6.7 nTPM
Pancreas	20.4 nTPM
Lung	16.6 nTPM
Ovary	14.7 nTPM
Spleen	6.2 nTPM
Stomach	5.9 nTPM
Prostate	5.7 nTPM
Testis	5.2 nTPM
Endometrium	4.8 nTPM
Skeletal muscle	4.7 nTPM
Kidney	4.6 nTPM
Breast	3.3 nTPM
Esophagus	3.1 nTPM
Bone marrow	2.5 nTPM
Adipose tissue	2.4 nTPM
PBMC	0.0 nTPM

Paneth cells	16.8 nTPM
Rectum	23.2 nTPM
Colon	19.7 nTPM
Small intestine	7.5 nTPM

Plasma cells	2.5 nTPM
Stomach	4.9 nTPM
Adipose tissue	4.5 nTPM
Bone marrow	1.7 nTPM
Spleen	1.3 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	59.1 nTPM
Bronchus	90.6 nTPM
Lung	27.7 nTPM

Smooth muscle cells	5.7 nTPM
Bronchus	20.4 nTPM
Esophagus	10.9 nTPM
Skin	6.7 nTPM
Endometrium	4.6 nTPM
Pancreas	4.4 nTPM
Ovary	3.6 nTPM
Breast	3.4 nTPM
Prostate	2.8 nTPM
Skeletal muscle	2.5 nTPM
Adipose tissue	2.3 nTPM
Heart muscle	0.7 nTPM

T-cells	9.4 nTPM
Prostate	66.3 nTPM
Lung	38.0 nTPM
Esophagus	6.6 nTPM
Skin	6.0 nTPM
Lymph node	5.8 nTPM
Kidney	4.7 nTPM
Liver	4.2 nTPM
Endometrium	4.1 nTPM
Spleen	4.1 nTPM
Skeletal muscle	3.8 nTPM
Bone marrow	3.6 nTPM
Colon	3.3 nTPM
Stomach	3.3 nTPM
PBMC	2.3 nTPM
Breast	2.0 nTPM
Adipose tissue	1.6 nTPM
Ovary	0.0 nTPM

Basal keratinocytes	17.2 nTPM
Skin	17.2 nTPM

Basal prostatic cells	14.6 nTPM
Prostate	14.6 nTPM

Basal respiratory cells	14.9 nTPM
Bronchus	14.9 nTPM

Collecting duct cells	33.1 nTPM
Kidney	33.1 nTPM

Undifferentiated cells	23.7 nTPM
Small intestine	32.4 nTPM
Rectum	24.6 nTPM
Colon	14.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC