Single cell type - DCPS - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DCPS
Gene descriptionⁱ Full gene name according to HGNC.	Decapping enzyme, scavenger
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Plasma cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Plasma cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DCPS is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 1
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IGHG2	Immunoglobulin heavy constant gamma 2 (G2m marker)	0.7209	55
IGKV1D-16	Immunoglobulin kappa variable 1D-16	0.7167	55
IGKV2-24	Immunoglobulin kappa variable 2-24	0.7139	55
IGHV3-53	Immunoglobulin heavy variable 3-53	0.7136	55
MIXL1	Mix paired-like homeobox	0.7111	55
IGLV1-36	Immunoglobulin lambda variable 1-36	0.7101	55
CD38	CD38 molecule	0.7059	55
IGLV7-46	Immunoglobulin lambda variable 7-46	0.7025	55
IGLV10-54	Immunoglobulin lambda variable 10-54	0.7023	55
MZB1	Marginal zone B and B1 cell specific protein	0.6998	55
IGHJ1	Immunoglobulin heavy joining 1	0.6992	55
IGKV6D-21	Immunoglobulin kappa variable 6D-21 (non-functional)	0.6987	55
IGLV7-43	Immunoglobulin lambda variable 7-43	0.6969	55
TXNDC5	Thioredoxin domain containing 5	0.6930	55
IGHV3-64	Immunoglobulin heavy variable 3-64	0.6909	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.2 nTPM
Breast	19.2 nTPM
Adipose tissue	9.1 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	11.2 nTPM
Lung	11.2 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	31.2 nTPM
Liver	108.8 nTPM
Breast	32.1 nTPM
Kidney	28.5 nTPM
PBMC	28.5 nTPM
Bone marrow	27.8 nTPM
Spleen	24.3 nTPM
Colon	19.2 nTPM
Stomach	15.0 nTPM
Lymph node	14.9 nTPM
Adipose tissue	12.6 nTPM

Dendritic cells	35.3 nTPM
PBMC	55.8 nTPM
Breast	30.3 nTPM
Adipose tissue	20.0 nTPM

Endothelial cells	12.4 nTPM
Placenta	20.5 nTPM
Ovary	19.6 nTPM
Pancreas	19.3 nTPM
Breast	14.5 nTPM
Esophagus	14.4 nTPM
Eye	12.2 nTPM
Testis	12.2 nTPM
Endometrium	9.4 nTPM
Lung	9.3 nTPM
Skin	9.3 nTPM
Liver	9.2 nTPM
Prostate	8.7 nTPM
Skeletal muscle	8.1 nTPM
Heart muscle	6.3 nTPM

Fibroblasts	15.9 nTPM
Ovary	31.5 nTPM
Placenta	27.4 nTPM
Esophagus	22.5 nTPM
Breast	18.3 nTPM
Adipose tissue	17.1 nTPM
Skeletal muscle	15.4 nTPM
Skin	12.0 nTPM
Stomach	10.4 nTPM
Prostate	9.5 nTPM
Heart muscle	6.6 nTPM
Lung	4.5 nTPM

Intestinal goblet cells	12.0 nTPM
Colon	15.0 nTPM
Rectum	13.3 nTPM
Small intestine	7.5 nTPM

Macrophages	16.8 nTPM
Kidney	31.0 nTPM
Esophagus	28.3 nTPM
Stomach	26.4 nTPM
Endometrium	25.6 nTPM
Prostate	20.7 nTPM
Breast	18.0 nTPM
Spleen	17.6 nTPM
Testis	16.3 nTPM
Ovary	15.9 nTPM
Bone marrow	15.0 nTPM
Skeletal muscle	13.8 nTPM
Adipose tissue	10.4 nTPM
Lung	7.9 nTPM
Pancreas	5.1 nTPM
PBMC	0.0 nTPM

Paneth cells	14.9 nTPM
Rectum	26.4 nTPM
Small intestine	15.0 nTPM
Colon	3.3 nTPM

Plasma cells	101.1 nTPM
Spleen	154.1 nTPM
Bone marrow	151.6 nTPM
Stomach	132.0 nTPM
Esophagus	55.5 nTPM
Adipose tissue	12.2 nTPM

Respiratory ciliated cells	15.7 nTPM
Lung	17.5 nTPM
Bronchus	13.8 nTPM

Smooth muscle cells	14.6 nTPM
Pancreas	34.4 nTPM
Bronchus	20.8 nTPM
Breast	15.5 nTPM
Ovary	14.0 nTPM
Skin	13.2 nTPM
Skeletal muscle	12.7 nTPM
Endometrium	11.2 nTPM
Prostate	11.0 nTPM
Adipose tissue	11.0 nTPM
Esophagus	9.3 nTPM
Heart muscle	7.2 nTPM

T-cells	24.3 nTPM
Ovary	37.8 nTPM
Kidney	33.6 nTPM
Stomach	33.3 nTPM
Liver	33.0 nTPM
Lung	31.9 nTPM
Bone marrow	31.6 nTPM
Spleen	27.2 nTPM
Esophagus	26.2 nTPM
Prostate	23.6 nTPM
PBMC	21.8 nTPM
Skin	20.2 nTPM
Colon	19.5 nTPM
Breast	17.1 nTPM
Skeletal muscle	15.2 nTPM
Lymph node	14.7 nTPM
Endometrium	13.3 nTPM
Adipose tissue	13.0 nTPM

Basal keratinocytes	6.9 nTPM
Skin	6.9 nTPM

Basal prostatic cells	16.4 nTPM
Prostate	16.4 nTPM

Basal respiratory cells	38.7 nTPM
Bronchus	38.7 nTPM

Basal squamous epithelial cells	8.0 nTPM
Esophagus	8.0 nTPM

Undifferentiated cells	14.4 nTPM
Colon	14.9 nTPM
Rectum	14.3 nTPM
Small intestine	14.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC