Single cell type - HIPK3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HIPK3
Gene descriptionⁱ Full gene name according to HGNC.	Homeodomain interacting protein kinase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Adipocytes & Endothelial cells - Angiogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HIPK3 is part of cluster 14 Adipocytes & Endothelial cells - Angiogenesis with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TAOK1	TAO kinase 1	0.5814	10
CD93	CD93 molecule	0.5545	14
WNK1	WNK lysine deficient protein kinase 1	0.5301	10
MAP3K3	Mitogen-activated protein kinase kinase kinase 3	0.5132	19
WAC	WW domain containing adaptor with coiled-coil	0.4938	44
NRN1	Neuritin 1	0.4899	14
EGLN1	Egl-9 family hypoxia inducible factor 1	0.4878	14
SOCS3	Suppressor of cytokine signaling 3	0.4784	14
SELE	Selectin E	0.4784	14
FAM110D	Family with sequence similarity 110 member D	0.4709	14
APOLD1	Apolipoprotein L domain containing 1	0.4650	14
MCMBP	Minichromosome maintenance complex binding protein	0.4640	12
KCTD12	Potassium channel tetramerization domain containing 12	0.4556	4
ANKRD40	Ankyrin repeat domain 40	0.4527	48
CLEC1A	C-type lectin domain family 1 member A	0.4488	38

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	44.7 nTPM
Lung	44.7 nTPM

Astrocytes	46.0 nTPM
Brain	46.0 nTPM

B-cells	29.6 nTPM
Adipose tissue	54.2 nTPM
Lymph node	36.8 nTPM
Stomach	34.9 nTPM
Breast	32.1 nTPM
Spleen	28.7 nTPM
Bone marrow	27.0 nTPM
Kidney	23.8 nTPM
Colon	22.3 nTPM
PBMC	21.4 nTPM
Liver	15.1 nTPM

Basal keratinocytes	66.5 nTPM
Skin	66.5 nTPM

Dendritic cells	31.2 nTPM
Adipose tissue	47.9 nTPM
Breast	33.9 nTPM
PBMC	12.0 nTPM

Endothelial cells	96.5 nTPM
Skin	251.0 nTPM
Esophagus	216.7 nTPM
Prostate	141.5 nTPM
Skeletal muscle	115.5 nTPM
Heart muscle	101.6 nTPM
Endometrium	98.9 nTPM
Testis	88.3 nTPM
Breast	87.5 nTPM
Lung	77.9 nTPM
Eye	51.0 nTPM
Ovary	44.0 nTPM
Liver	33.9 nTPM
Placenta	23.9 nTPM
Pancreas	19.3 nTPM

Fibroblasts	59.2 nTPM
Heart muscle	102.7 nTPM
Stomach	87.6 nTPM
Adipose tissue	86.9 nTPM
Skin	76.2 nTPM
Skeletal muscle	70.7 nTPM
Lung	60.3 nTPM
Esophagus	44.1 nTPM
Breast	43.3 nTPM
Prostate	41.8 nTPM
Placenta	26.7 nTPM
Ovary	10.6 nTPM

Intestinal goblet cells	28.4 nTPM
Rectum	36.5 nTPM
Colon	26.4 nTPM
Small intestine	22.3 nTPM

Macrophages	68.1 nTPM
Adipose tissue	159.7 nTPM
Spleen	101.6 nTPM
Bone marrow	94.9 nTPM
Stomach	90.8 nTPM
Skeletal muscle	86.6 nTPM
Testis	69.2 nTPM
Esophagus	67.7 nTPM
Ovary	62.0 nTPM
Kidney	58.2 nTPM
Prostate	57.3 nTPM
Endometrium	51.5 nTPM
Lung	46.3 nTPM
Breast	39.3 nTPM
Pancreas	23.0 nTPM
PBMC	13.6 nTPM

Paneth cells	21.1 nTPM
Small intestine	26.3 nTPM
Rectum	23.9 nTPM
Colon	13.2 nTPM

Plasma cells	24.9 nTPM
Adipose tissue	51.6 nTPM
Stomach	25.4 nTPM
Esophagus	18.4 nTPM
Bone marrow	16.5 nTPM
Spleen	12.7 nTPM

Respiratory ciliated cells	65.4 nTPM
Lung	65.6 nTPM
Bronchus	65.3 nTPM

Smooth muscle cells	56.4 nTPM
Adipose tissue	92.9 nTPM
Skin	81.2 nTPM
Skeletal muscle	70.5 nTPM
Heart muscle	69.8 nTPM
Breast	65.8 nTPM
Prostate	65.3 nTPM
Endometrium	55.3 nTPM
Ovary	38.9 nTPM
Esophagus	38.8 nTPM
Bronchus	33.1 nTPM
Pancreas	8.6 nTPM

T-cells	29.8 nTPM
Adipose tissue	62.2 nTPM
Skeletal muscle	44.5 nTPM
Breast	42.0 nTPM
Endometrium	38.8 nTPM
Lymph node	36.1 nTPM
Skin	33.2 nTPM
Bone marrow	33.2 nTPM
Spleen	29.2 nTPM
Stomach	28.4 nTPM
Colon	28.0 nTPM
Ovary	26.7 nTPM
Prostate	23.6 nTPM
PBMC	22.3 nTPM
Liver	19.9 nTPM
Lung	18.2 nTPM
Kidney	13.7 nTPM
Esophagus	6.6 nTPM

Cholangiocytes	37.1 nTPM
Liver	37.1 nTPM

Cone photoreceptor cells	18.8 nTPM
Eye	18.8 nTPM

Cytotrophoblasts	18.6 nTPM
Placenta	18.6 nTPM

Distal tubular cells	5.9 nTPM
Kidney	5.9 nTPM

Undifferentiated cells	25.2 nTPM
Rectum	27.1 nTPM
Colon	24.5 nTPM
Small intestine	24.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC