Single cell type - CREBL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CREBL2
Gene descriptionⁱ Full gene name according to HGNC.	CAMP responsive element binding protein like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CREBL2 is part of cluster 4 Macrophages - Innate immune response with confidenceⁱ 1
228 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TPP1	Tripeptidyl peptidase 1	0.6521	4
FTL	Ferritin light chain	0.6194	4
CD163	CD163 molecule	0.6032	4
MS4A6A	Membrane spanning 4-domains A6A	0.5957	4
FPR3	Formyl peptide receptor 3	0.5896	4
CREG1	Cellular repressor of E1A stimulated genes 1	0.5808	4
CD4	CD4 molecule	0.5768	4
PPT1	Palmitoyl-protein thioesterase 1	0.5648	4
C1QC	Complement C1q C chain	0.5642	4
C1QB	Complement C1q B chain	0.5537	4
CD5L	CD5 molecule like	0.5499	4
PPM1M	Protein phosphatase, Mg2+/Mn2+ dependent 1M	0.5489	63
IL10	Interleukin 10	0.5471	41
C1QA	Complement C1q A chain	0.5462	4
HNMT	Histamine N-methyltransferase	0.5429	4

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	18.0 nTPM
Adipose tissue	19.4 nTPM
Breast	16.7 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	26.5 nTPM
Lung	26.5 nTPM

Astrocytes	23.5 nTPM
Brain	23.5 nTPM

B-cells	14.8 nTPM
Kidney	23.8 nTPM
Spleen	20.8 nTPM
Stomach	15.9 nTPM
Liver	15.1 nTPM
Lymph node	15.0 nTPM
PBMC	12.9 nTPM
Colon	12.8 nTPM
Bone marrow	12.3 nTPM
Adipose tissue	10.0 nTPM
Breast	9.4 nTPM

Dendritic cells	15.7 nTPM
PBMC	16.0 nTPM
Adipose tissue	16.0 nTPM
Breast	15.3 nTPM

Endothelial cells	19.1 nTPM
Liver	42.2 nTPM
Testis	24.9 nTPM
Prostate	23.9 nTPM
Breast	23.6 nTPM
Skin	22.9 nTPM
Eye	18.6 nTPM
Heart muscle	18.1 nTPM
Esophagus	17.4 nTPM
Ovary	16.0 nTPM
Endometrium	13.2 nTPM
Placenta	13.1 nTPM
Skeletal muscle	13.1 nTPM
Lung	12.5 nTPM
Pancreas	7.7 nTPM

Fibroblasts	25.3 nTPM
Esophagus	46.5 nTPM
Adipose tissue	41.3 nTPM
Breast	35.5 nTPM
Skin	31.8 nTPM
Skeletal muscle	29.1 nTPM
Stomach	28.2 nTPM
Prostate	20.9 nTPM
Heart muscle	16.4 nTPM
Placenta	14.2 nTPM
Lung	7.8 nTPM
Ovary	6.9 nTPM

Intestinal goblet cells	16.4 nTPM
Rectum	21.7 nTPM
Small intestine	16.9 nTPM
Colon	10.7 nTPM

Macrophages	58.2 nTPM
Ovary	102.8 nTPM
Spleen	95.4 nTPM
Prostate	87.1 nTPM
Bone marrow	86.2 nTPM
Adipose tissue	82.0 nTPM
Esophagus	72.4 nTPM
Testis	65.6 nTPM
Kidney	54.4 nTPM
Skeletal muscle	45.9 nTPM
Breast	44.7 nTPM
Pancreas	35.7 nTPM
Endometrium	33.8 nTPM
Lung	26.6 nTPM
Stomach	26.4 nTPM
PBMC	13.6 nTPM

Paneth cells	15.0 nTPM
Rectum	23.9 nTPM
Small intestine	11.3 nTPM
Colon	9.9 nTPM

Plasma cells	17.3 nTPM
Esophagus	24.6 nTPM
Stomach	23.4 nTPM
Spleen	18.5 nTPM
Adipose tissue	13.6 nTPM
Bone marrow	6.6 nTPM

Respiratory ciliated cells	19.9 nTPM
Bronchus	22.3 nTPM
Lung	17.5 nTPM

Smooth muscle cells	12.4 nTPM
Skin	22.7 nTPM
Esophagus	21.7 nTPM
Adipose tissue	16.6 nTPM
Breast	15.1 nTPM
Skeletal muscle	13.4 nTPM
Pancreas	10.7 nTPM
Ovary	10.2 nTPM
Prostate	9.7 nTPM
Endometrium	7.5 nTPM
Heart muscle	7.4 nTPM
Bronchus	1.9 nTPM

T-cells	23.3 nTPM
Skin	41.9 nTPM
Colon	36.6 nTPM
Lymph node	36.5 nTPM
Adipose tissue	31.5 nTPM
Spleen	28.1 nTPM
Stomach	26.9 nTPM
Prostate	23.6 nTPM
Liver	21.9 nTPM
PBMC	21.6 nTPM
Bone marrow	21.3 nTPM
Breast	19.4 nTPM
Skeletal muscle	16.7 nTPM
Kidney	16.4 nTPM
Lung	15.2 nTPM
Ovary	13.4 nTPM
Esophagus	13.1 nTPM
Endometrium	12.1 nTPM

Basal keratinocytes	22.2 nTPM
Skin	22.2 nTPM

Basal respiratory cells	11.1 nTPM
Bronchus	11.1 nTPM

Basal squamous epithelial cells	18.8 nTPM
Esophagus	18.8 nTPM

Cholangiocytes	30.0 nTPM
Liver	30.0 nTPM

Undifferentiated cells	17.6 nTPM
Rectum	22.1 nTPM
Small intestine	18.2 nTPM
Colon	12.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC