Single cell type - MGP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MGP
Gene descriptionⁱ Full gene name according to HGNC.	Matrix Gla protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Glandular cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Breast glandular cells, Breast myoepithelial cells, Fibroblasts, Leydig cells, Hepatic stellate cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (AN3-CA)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Breast glandular cells, Breast myoepithelial cells, Fibroblasts, Leydig cells, Hepatic stellate cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MGP is part of cluster 35 Glandular cells - Unknown function with confidenceⁱ 1
101 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
VSIG10L2	V-set and immunoglobulin domain containing 10 like 2	0.7963	35
SFRP1	Secreted frizzled related protein 1	0.7503	35
LMX1B	LIM homeobox transcription factor 1 beta	0.7460	35
FZD7	Frizzled class receptor 7	0.7376	35
CST9	Cystatin 9	0.7139	35
PIP	Prolactin induced protein	0.7127	35
ANKRD30A	Ankyrin repeat domain 30A	0.7080	35
SCGB2A2	Secretoglobin family 2A member 2	0.7075	35
MUCL1	Mucin like 1	0.7053	35
SNORC	Secondary ossification center associated regulator of chondrocyte maturation	0.6932	35
OPRPN	Opiorphin prepropeptide	0.6917	35
OTOR	Otoraplin	0.6769	35
GFRA1	GDNF family receptor alpha 1	0.6748	50
IL22RA2	Interleukin 22 receptor subunit alpha 2	0.6705	35
SLC39A6	Solute carrier family 39 member 6	0.6700	35

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	451.0 nTPM
Adipose tissue	533.6 nTPM
Breast	368.3 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	72.8 nTPM
Lung	72.8 nTPM

Astrocytes	1.3 nTPM
Brain	1.3 nTPM

B-cells	29.9 nTPM
Breast	243.4 nTPM
Kidney	28.5 nTPM
Liver	17.7 nTPM
Adipose tissue	4.0 nTPM
Stomach	3.2 nTPM
Lymph node	1.5 nTPM
Bone marrow	0.8 nTPM
Colon	0.0 nTPM
PBMC	0.0 nTPM
Spleen	0.0 nTPM

Dendritic cells	85.7 nTPM
Breast	248.6 nTPM
Adipose tissue	4.5 nTPM
PBMC	4.0 nTPM

Endothelial cells	856.1 nTPM
Testis	3119.7 nTPM
Liver	1190.5 nTPM
Breast	1160.8 nTPM
Ovary	1078.5 nTPM
Heart muscle	1001.8 nTPM
Lung	680.0 nTPM
Prostate	642.9 nTPM
Pancreas	606.1 nTPM
Esophagus	555.8 nTPM
Skin	485.2 nTPM
Endometrium	462.0 nTPM
Skeletal muscle	425.2 nTPM
Placenta	322.3 nTPM
Eye	254.9 nTPM

Fibroblasts	4233.6 nTPM
Adipose tissue	11770.6 nTPM
Stomach	7320.5 nTPM
Prostate	5992.2 nTPM
Esophagus	5557.8 nTPM
Skeletal muscle	4355.6 nTPM
Heart muscle	3457.4 nTPM
Breast	3158.6 nTPM
Placenta	1911.7 nTPM
Skin	1581.9 nTPM
Lung	1426.5 nTPM
Ovary	36.9 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	36.1 nTPM
Skeletal muscle	193.0 nTPM
Breast	158.8 nTPM
Esophagus	40.9 nTPM
Testis	38.9 nTPM
Prostate	35.5 nTPM
Lung	30.7 nTPM
Adipose tissue	18.6 nTPM
Endometrium	16.7 nTPM
Kidney	4.6 nTPM
Stomach	2.9 nTPM
Ovary	0.3 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	1.1 nTPM
Colon	3.3 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	17.0 nTPM
Stomach	36.3 nTPM
Adipose tissue	30.3 nTPM
Esophagus	18.4 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	25.8 nTPM
Lung	49.5 nTPM
Bronchus	2.0 nTPM

Smooth muscle cells	847.0 nTPM
Adipose tissue	2292.5 nTPM
Prostate	1467.5 nTPM
Endometrium	1295.4 nTPM
Breast	963.6 nTPM
Esophagus	930.3 nTPM
Skeletal muscle	865.3 nTPM
Skin	683.3 nTPM
Heart muscle	621.3 nTPM
Ovary	135.5 nTPM
Pancreas	60.4 nTPM
Bronchus	1.8 nTPM

T-cells	54.5 nTPM
Breast	326.8 nTPM
Skeletal muscle	203.5 nTPM
Skin	140.9 nTPM
Kidney	101.3 nTPM
Esophagus	72.0 nTPM
Endometrium	30.9 nTPM
Lung	24.3 nTPM
Prostate	9.5 nTPM
Stomach	5.2 nTPM
Lymph node	4.7 nTPM
Bone marrow	3.1 nTPM
Liver	3.0 nTPM
Adipose tissue	1.7 nTPM
PBMC	0.2 nTPM
Colon	0.0 nTPM
Ovary	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	149.3 nTPM
Skin	149.3 nTPM

Basal prostatic cells	220.4 nTPM
Prostate	220.4 nTPM

Basal squamous epithelial cells	19.9 nTPM
Esophagus	19.9 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC