Single cell type - GNPTAB - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GNPTAB
Gene descriptionⁱ Full gene name according to HGNC.	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (NK-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (NK-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GNPTAB is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MAPK1	Mitogen-activated protein kinase 1	0.6913	63
KIR3DL1	Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	0.6901	63
KIR2DL1	Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	0.6879	63
KIR2DL3	Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3	0.6796	63
GNLY	Granulysin	0.6795	63
SH2D1B	SH2 domain containing 1B	0.6753	63
KLRD1	Killer cell lectin like receptor D1	0.6641	63
KIR3DL3	Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3	0.6612	63
CEP78	Centrosomal protein 78	0.6565	63
IL18RAP	Interleukin 18 receptor accessory protein	0.6557	63
NKG7	Natural killer cell granule protein 7	0.6498	63
NCR1	Natural cytotoxicity triggering receptor 1	0.6494	63
KIR3DL2	Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2	0.6492	63
SAMD3	Sterile alpha motif domain containing 3	0.6483	63
PRF1	Perforin 1	0.6458	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	25.3 nTPM
Adipose tissue	28.8 nTPM
Breast	21.8 nTPM

Alveolar cells type 1	60.9 nTPM
Lung	60.9 nTPM

Alveolar cells type 2	65.0 nTPM
Lung	65.0 nTPM

Astrocytes	35.9 nTPM
Brain	35.9 nTPM

B-cells	42.1 nTPM
Adipose tissue	88.2 nTPM
Stomach	77.7 nTPM
Kidney	47.6 nTPM
Colon	35.1 nTPM
Spleen	33.2 nTPM
Lymph node	32.0 nTPM
Bone marrow	31.9 nTPM
PBMC	28.5 nTPM
Breast	25.5 nTPM
Liver	21.5 nTPM

Dendritic cells	107.3 nTPM
Adipose tissue	229.0 nTPM
Breast	68.9 nTPM
PBMC	23.9 nTPM

Endothelial cells	21.1 nTPM
Heart muscle	40.4 nTPM
Lung	37.4 nTPM
Skeletal muscle	34.4 nTPM
Eye	26.7 nTPM
Endometrium	26.2 nTPM
Ovary	25.6 nTPM
Esophagus	19.1 nTPM
Breast	18.7 nTPM
Placenta	13.7 nTPM
Testis	12.5 nTPM
Liver	11.9 nTPM
Skin	10.7 nTPM
Prostate	9.9 nTPM
Pancreas	7.7 nTPM

Fibroblasts	18.9 nTPM
Heart muscle	32.4 nTPM
Skeletal muscle	27.0 nTPM
Adipose tissue	23.3 nTPM
Ovary	22.6 nTPM
Breast	21.1 nTPM
Esophagus	18.3 nTPM
Lung	15.7 nTPM
Skin	13.3 nTPM
Prostate	12.2 nTPM
Placenta	11.5 nTPM
Stomach	10.4 nTPM

Intestinal goblet cells	29.6 nTPM
Rectum	50.0 nTPM
Small intestine	21.6 nTPM
Colon	17.2 nTPM

Macrophages	41.2 nTPM
Ovary	97.7 nTPM
Endometrium	65.6 nTPM
Bone marrow	60.0 nTPM
Spleen	50.8 nTPM
Lung	49.6 nTPM
Prostate	45.8 nTPM
Adipose tissue	41.7 nTPM
Pancreas	40.8 nTPM
Skeletal muscle	39.6 nTPM
Testis	36.6 nTPM
Breast	29.9 nTPM
Kidney	22.7 nTPM
Stomach	20.5 nTPM
Esophagus	17.3 nTPM
PBMC	0.0 nTPM

Paneth cells	129.3 nTPM
Rectum	268.4 nTPM
Colon	85.7 nTPM
Small intestine	33.8 nTPM

Plasma cells	63.9 nTPM
Adipose tissue	143.9 nTPM
Stomach	63.3 nTPM
Spleen	53.3 nTPM
Bone marrow	34.6 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	10.0 nTPM
Lung	10.2 nTPM
Bronchus	9.8 nTPM

Smooth muscle cells	14.9 nTPM
Heart muscle	22.6 nTPM
Adipose tissue	18.8 nTPM
Ovary	18.4 nTPM
Skeletal muscle	18.0 nTPM
Endometrium	15.4 nTPM
Breast	15.0 nTPM
Pancreas	14.4 nTPM
Esophagus	14.0 nTPM
Prostate	11.6 nTPM
Bronchus	9.4 nTPM
Skin	5.9 nTPM

T-cells	63.4 nTPM
Endometrium	153.1 nTPM
Skeletal muscle	93.3 nTPM
Bone marrow	82.8 nTPM
Liver	79.2 nTPM
Adipose tissue	76.9 nTPM
Prostate	75.7 nTPM
Ovary	75.7 nTPM
Colon	70.8 nTPM
Lung	65.3 nTPM
Kidney	62.9 nTPM
Stomach	55.0 nTPM
PBMC	45.2 nTPM
Spleen	38.8 nTPM
Breast	34.8 nTPM
Lymph node	30.9 nTPM
Skin	24.0 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	16.8 nTPM
Skin	16.8 nTPM

Basal prostatic cells	32.9 nTPM
Prostate	32.9 nTPM

Basal respiratory cells	16.2 nTPM
Bronchus	16.2 nTPM

Basal squamous epithelial cells	17.1 nTPM
Esophagus	17.1 nTPM

Undifferentiated cells	49.7 nTPM
Rectum	95.2 nTPM
Colon	39.0 nTPM
Small intestine	15.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC