Single cell type - TDP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TDP2
Gene descriptionⁱ Full gene name according to HGNC.	Tyrosyl-DNA phosphodiesterase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Enterocytes - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TDP2 is part of cluster 45 Enterocytes - Digestion with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BTNL3	Butyrophilin like 3	0.8947	45
CLRN3	Clarin 3	0.8657	45
TUBAL3	Tubulin alpha like 3	0.8579	45
TMIGD1	Transmembrane and immunoglobulin domain containing 1	0.8482	45
CCL15	C-C motif chemokine ligand 15	0.8413	45
LRRC19	Leucine rich repeat containing 19	0.8354	53
RETSAT	Retinol saturase	0.8298	45
GNA11	G protein subunit alpha 11	0.8287	45
BTNL8	Butyrophilin like 8	0.8257	45
TTC22	Tetratricopeptide repeat domain 22	0.8256	53
HHLA2	HERV-H LTR-associating 2	0.8220	53
SMPDL3A	Sphingomyelin phosphodiesterase acid like 3A	0.8215	45
MEP1A	Meprin A subunit alpha	0.8077	45
SULT1B1	Sulfotransferase family 1B member 1	0.8035	53
AQP12A	Aquaporin 12A	0.8034	45

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	24.0 nTPM
Breast	28.2 nTPM
Adipose tissue	19.8 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	16.7 nTPM
Lung	16.7 nTPM

Astrocytes	23.5 nTPM
Brain	23.5 nTPM

B-cells	24.1 nTPM
Colon	33.5 nTPM
Stomach	30.4 nTPM
Lymph node	28.9 nTPM
Spleen	24.6 nTPM
Kidney	23.8 nTPM
Adipose tissue	23.6 nTPM
PBMC	21.4 nTPM
Liver	21.3 nTPM
Bone marrow	18.8 nTPM
Breast	14.7 nTPM

Dendritic cells	23.0 nTPM
Breast	29.5 nTPM
Adipose tissue	27.5 nTPM
PBMC	12.0 nTPM

Endothelial cells	22.5 nTPM
Liver	32.1 nTPM
Pancreas	30.9 nTPM
Breast	29.0 nTPM
Heart muscle	26.7 nTPM
Skin	26.5 nTPM
Testis	23.1 nTPM
Lung	21.8 nTPM
Prostate	21.3 nTPM
Skeletal muscle	20.6 nTPM
Ovary	19.9 nTPM
Endometrium	18.4 nTPM
Esophagus	18.4 nTPM
Placenta	17.0 nTPM
Eye	8.9 nTPM

Fibroblasts	18.3 nTPM
Prostate	29.7 nTPM
Esophagus	24.1 nTPM
Breast	22.2 nTPM
Skin	20.1 nTPM
Adipose tissue	18.8 nTPM
Skeletal muscle	18.2 nTPM
Placenta	15.6 nTPM
Stomach	14.9 nTPM
Ovary	14.7 nTPM
Heart muscle	13.4 nTPM
Lung	10.1 nTPM

Intestinal goblet cells	168.9 nTPM
Small intestine	171.1 nTPM
Colon	169.4 nTPM
Rectum	166.1 nTPM

Macrophages	33.5 nTPM
Pancreas	127.6 nTPM
Ovary	58.0 nTPM
Kidney	37.1 nTPM
Prostate	36.7 nTPM
Lung	36.4 nTPM
Breast	27.8 nTPM
PBMC	27.3 nTPM
Testis	26.1 nTPM
Spleen	22.8 nTPM
Skeletal muscle	21.7 nTPM
Esophagus	18.9 nTPM
Bone marrow	18.8 nTPM
Stomach	17.6 nTPM
Adipose tissue	15.5 nTPM
Endometrium	10.6 nTPM

Paneth cells	428.1 nTPM
Colon	500.7 nTPM
Small intestine	461.7 nTPM
Rectum	321.8 nTPM

Plasma cells	10.7 nTPM
Spleen	17.1 nTPM
Bone marrow	14.8 nTPM
Adipose tissue	11.6 nTPM
Stomach	9.9 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	30.5 nTPM
Bronchus	32.0 nTPM
Lung	29.1 nTPM

Smooth muscle cells	20.4 nTPM
Pancreas	36.0 nTPM
Skin	25.8 nTPM
Prostate	22.8 nTPM
Esophagus	21.7 nTPM
Bronchus	21.6 nTPM
Breast	19.5 nTPM
Heart muscle	18.4 nTPM
Adipose tissue	15.2 nTPM
Skeletal muscle	14.7 nTPM
Ovary	14.7 nTPM
Endometrium	13.4 nTPM

T-cells	28.5 nTPM
Kidney	50.0 nTPM
Colon	42.3 nTPM
PBMC	36.0 nTPM
Liver	33.6 nTPM
Lymph node	32.7 nTPM
Breast	32.2 nTPM
Bone marrow	31.5 nTPM
Stomach	28.1 nTPM
Spleen	27.0 nTPM
Ovary	26.7 nTPM
Adipose tissue	26.7 nTPM
Lung	25.8 nTPM
Skin	24.9 nTPM
Skeletal muscle	22.9 nTPM
Endometrium	21.2 nTPM
Esophagus	13.1 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	14.1 nTPM
Skin	14.1 nTPM

Basal prostatic cells	25.1 nTPM
Prostate	25.1 nTPM

Basal respiratory cells	37.0 nTPM
Bronchus	37.0 nTPM

Collecting duct cells	22.0 nTPM
Kidney	22.0 nTPM

Undifferentiated cells	119.3 nTPM
Colon	165.1 nTPM
Rectum	108.7 nTPM
Small intestine	84.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC