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The Opioid receptor mu 1 is an inhibitory G-protein coupled receptor that can exhibit a presynaptic or postsynaptic pattern, with its RNA transcripts showing weak to moderate expression throughout the human brain. In the mouse, however, strong but spatially highly restricted immunoreactivity is seen in a few nuclei/axonal tracts throughout the brain, where dendritic network as well as occasional cells bodies are also depicted. The staining is restricted to parts of the habenulointerpeduncular pathway, septofimbrial nucleus, stria medullaris, some 'islets' of the caudate putamen, the nucleus accumbens, parts of the lateral septum, the lateral parabrachial nucleus, the periaqueductal gray and the caudal subdivision of the dorsal raphe. In addition, less intense, diffuse synaptic staining is noticed in the central medial and paraventricular thalamic nuclei.
Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
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The Human Protein Atlas project is funded
