Single cell type - MAPK14 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAPK14
Gene descriptionⁱ Full gene name according to HGNC.	Mitogen-activated protein kinase 14
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes & Neutrophils - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (basophil, neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MAPK14 is part of cluster 19 Monocytes & Neutrophils - Innate immune response with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BAG4	BAG cochaperone 4	0.5306	59
EIF4E3	Eukaryotic translation initiation factor 4E family member 3	0.5090	19
TLK1	Tousled like kinase 1	0.4971	21
ADCY9	Adenylate cyclase 9	0.4969	21
DMXL2	Dmx like 2	0.4855	19
NLRC4	NLR family CARD domain containing 4	0.4849	19
FAM151B	Family with sequence similarity 151 member B	0.4831	8
LYST	Lysosomal trafficking regulator	0.4775	19
TMEM170B	Transmembrane protein 170B	0.4771	19
STK38	Serine/threonine kinase 38	0.4747	63
ARNT	Aryl hydrocarbon receptor nuclear translocator	0.4738	2
ARRB1	Arrestin beta 1	0.4678	8
S100Z	S100 calcium binding protein Z	0.4644	19
AMPH	Amphiphysin	0.4639	8
PRAM1	PML-RARA regulated adaptor molecule 1	0.4590	19

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	24.4 nTPM
Adipose tissue	29.3 nTPM
Breast	19.6 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	13.9 nTPM
Lung	13.9 nTPM

Astrocytes	37.2 nTPM
Brain	37.2 nTPM

B-cells	22.6 nTPM
PBMC	31.5 nTPM
Bone marrow	28.6 nTPM
Liver	26.1 nTPM
Lymph node	25.0 nTPM
Kidney	23.8 nTPM
Stomach	21.8 nTPM
Breast	21.3 nTPM
Spleen	21.1 nTPM
Adipose tissue	20.1 nTPM
Colon	6.4 nTPM

Dendritic cells	26.8 nTPM
Adipose tissue	45.4 nTPM
Breast	22.9 nTPM
PBMC	12.0 nTPM

Endothelial cells	22.6 nTPM
Liver	31.2 nTPM
Pancreas	30.9 nTPM
Testis	27.5 nTPM
Skeletal muscle	25.3 nTPM
Lung	24.9 nTPM
Ovary	24.9 nTPM
Esophagus	24.7 nTPM
Skin	24.5 nTPM
Heart muscle	21.7 nTPM
Endometrium	19.7 nTPM
Breast	18.7 nTPM
Placenta	15.3 nTPM
Eye	13.7 nTPM
Prostate	13.2 nTPM

Fibroblasts	25.9 nTPM
Heart muscle	40.2 nTPM
Esophagus	38.4 nTPM
Skeletal muscle	33.3 nTPM
Adipose tissue	33.3 nTPM
Placenta	29.8 nTPM
Skin	22.5 nTPM
Stomach	22.3 nTPM
Breast	21.1 nTPM
Ovary	17.3 nTPM
Prostate	15.2 nTPM
Lung	11.1 nTPM

Intestinal goblet cells	25.4 nTPM
Rectum	29.0 nTPM
Small intestine	28.7 nTPM
Colon	18.6 nTPM

Macrophages	38.5 nTPM
PBMC	81.8 nTPM
Bone marrow	56.3 nTPM
Stomach	52.7 nTPM
Spleen	46.7 nTPM
Testis	45.3 nTPM
Skeletal muscle	40.9 nTPM
Lung	40.2 nTPM
Kidney	35.6 nTPM
Ovary	35.3 nTPM
Adipose tissue	31.0 nTPM
Endometrium	28.7 nTPM
Prostate	27.5 nTPM
Esophagus	23.6 nTPM
Breast	19.3 nTPM
Pancreas	12.8 nTPM

Paneth cells	16.2 nTPM
Small intestine	26.3 nTPM
Rectum	22.4 nTPM
Colon	0.0 nTPM

Plasma cells	27.7 nTPM
Adipose tissue	43.9 nTPM
Esophagus	30.7 nTPM
Spleen	24.5 nTPM
Stomach	21.4 nTPM
Bone marrow	18.2 nTPM

Respiratory ciliated cells	20.9 nTPM
Bronchus	24.3 nTPM
Lung	17.5 nTPM

Smooth muscle cells	15.7 nTPM
Adipose tissue	24.0 nTPM
Esophagus	21.7 nTPM
Heart muscle	20.3 nTPM
Endometrium	18.3 nTPM
Prostate	14.7 nTPM
Breast	14.6 nTPM
Ovary	14.2 nTPM
Skeletal muscle	13.7 nTPM
Pancreas	13.3 nTPM
Skin	10.8 nTPM
Bronchus	7.5 nTPM

T-cells	28.0 nTPM
Ovary	42.2 nTPM
Adipose tissue	36.7 nTPM
Bone marrow	34.3 nTPM
Liver	33.3 nTPM
Esophagus	32.8 nTPM
Skeletal muscle	32.4 nTPM
PBMC	29.5 nTPM
Skin	29.5 nTPM
Kidney	29.4 nTPM
Spleen	27.1 nTPM
Endometrium	25.1 nTPM
Lymph node	24.3 nTPM
Prostate	23.6 nTPM
Breast	22.5 nTPM
Stomach	20.8 nTPM
Colon	18.1 nTPM
Lung	15.2 nTPM

Basal keratinocytes	15.9 nTPM
Skin	15.9 nTPM

Basal prostatic cells	11.0 nTPM
Prostate	11.0 nTPM

Basal squamous epithelial cells	28.5 nTPM
Esophagus	28.5 nTPM

Cholangiocytes	14.3 nTPM
Liver	14.3 nTPM

Undifferentiated cells	18.8 nTPM
Rectum	23.4 nTPM
Small intestine	20.5 nTPM
Colon	12.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC