Single cell type - QKI - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	QKI
Gene descriptionⁱ Full gene name according to HGNC.	QKI, KH domain containing RNA binding
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Astrocytes, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AF22)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Astrocytes, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

QKI is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SHROOM4	Shroom family member 4	0.6450	42
ELMO1	Engulfment and cell motility 1	0.6376	42
PICALM	Phosphatidylinositol binding clathrin assembly protein	0.6194	10
TCF12	Transcription factor 12	0.6157	42
SLCO1A2	Solute carrier organic anion transporter family member 1A2	0.6125	42
KCNH8	Potassium voltage-gated channel subfamily H member 8	0.6079	42
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.6074	42
MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4	0.6071	42
NCKAP5	NCK associated protein 5	0.6052	42
MAG	Myelin associated glycoprotein	0.5988	42
TMEM235	Transmembrane protein 235	0.5963	42
SLAIN1	SLAIN motif family member 1	0.5955	42
CARNS1	Carnosine synthase 1	0.5948	42
PLCL1	Phospholipase C like 1 (inactive)	0.5895	42
MOG	Myelin oligodendrocyte glycoprotein	0.5893	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	180.6 nTPM
Adipose tissue	213.1 nTPM
Breast	148.1 nTPM

Alveolar cells type 1	150.6 nTPM
Lung	150.6 nTPM

Alveolar cells type 2	51.5 nTPM
Lung	51.5 nTPM

B-cells	35.4 nTPM
Adipose tissue	76.7 nTPM
Colon	41.5 nTPM
PBMC	41.4 nTPM
Breast	37.5 nTPM
Liver	31.1 nTPM
Spleen	29.4 nTPM
Lymph node	29.3 nTPM
Kidney	28.5 nTPM
Bone marrow	22.9 nTPM
Stomach	15.9 nTPM

Basal keratinocytes	153.7 nTPM
Skin	153.7 nTPM

Dendritic cells	77.7 nTPM
Adipose tissue	98.7 nTPM
PBMC	91.6 nTPM
Breast	42.7 nTPM

Endothelial cells	130.0 nTPM
Ovary	197.7 nTPM
Skeletal muscle	182.3 nTPM
Eye	181.2 nTPM
Heart muscle	163.5 nTPM
Endometrium	160.2 nTPM
Skin	155.4 nTPM
Liver	111.9 nTPM
Testis	109.0 nTPM
Breast	102.5 nTPM
Prostate	100.4 nTPM
Lung	99.8 nTPM
Esophagus	92.5 nTPM
Placenta	87.0 nTPM
Pancreas	77.2 nTPM

Fibroblasts	92.2 nTPM
Adipose tissue	187.8 nTPM
Heart muscle	150.4 nTPM
Skin	144.4 nTPM
Skeletal muscle	116.0 nTPM
Ovary	85.2 nTPM
Breast	83.6 nTPM
Prostate	75.8 nTPM
Esophagus	58.1 nTPM
Stomach	44.6 nTPM
Placenta	39.8 nTPM
Lung	27.9 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	165.7 nTPM
Adipose tissue	357.5 nTPM
Endometrium	243.6 nTPM
Skeletal muscle	232.1 nTPM
Ovary	218.0 nTPM
Spleen	202.2 nTPM
Breast	161.7 nTPM
Testis	160.9 nTPM
Stomach	155.3 nTPM
Esophagus	144.8 nTPM
Prostate	143.4 nTPM
Bone marrow	128.7 nTPM
Lung	109.1 nTPM
Kidney	96.8 nTPM
PBMC	68.2 nTPM
Pancreas	63.8 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	34.4 nTPM
Adipose tissue	74.9 nTPM
Spleen	34.1 nTPM
Esophagus	24.6 nTPM
Stomach	23.6 nTPM
Bone marrow	14.8 nTPM

Respiratory ciliated cells	23.7 nTPM
Bronchus	24.0 nTPM
Lung	23.3 nTPM

Smooth muscle cells	83.5 nTPM
Adipose tissue	124.8 nTPM
Endometrium	123.6 nTPM
Heart muscle	108.5 nTPM
Ovary	102.6 nTPM
Skin	100.4 nTPM
Skeletal muscle	98.2 nTPM
Bronchus	75.8 nTPM
Breast	66.4 nTPM
Prostate	59.4 nTPM
Esophagus	29.4 nTPM
Pancreas	28.8 nTPM

T-cells	32.2 nTPM
Endometrium	68.7 nTPM
Skeletal muscle	66.1 nTPM
Adipose tissue	59.7 nTPM
Skin	50.2 nTPM
Ovary	35.6 nTPM
Breast	34.9 nTPM
Prostate	33.1 nTPM
Lung	28.8 nTPM
Colon	28.0 nTPM
Liver	20.3 nTPM
PBMC	20.1 nTPM
Spleen	19.8 nTPM
Esophagus	19.7 nTPM
Kidney	17.8 nTPM
Lymph node	16.6 nTPM
Bone marrow	16.2 nTPM
Stomach	11.5 nTPM

Astrocytes	1140.0 nTPM
Brain	1140.0 nTPM

Cholangiocytes	37.1 nTPM
Liver	37.1 nTPM

Collecting duct cells	20.2 nTPM
Kidney	20.2 nTPM

Cone photoreceptor cells	58.4 nTPM
Eye	58.4 nTPM

Undifferentiated cells	0.2 nTPM
Colon	0.6 nTPM
Rectum	0.1 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC