Single cell type - THG1L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	THG1L
Gene descriptionⁱ Full gene name according to HGNC.	TRNA-histidine guanylyltransferase 1 like
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

THG1L is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NOB1	NIN1 (RPN12) binding protein 1 homolog	0.6868	32
RSL1D1	Ribosomal L1 domain containing 1	0.6240	32
NIFK	Nucleolar protein interacting with the FHA domain of MKI67	0.5913	39
SLC25A6	Solute carrier family 25 member 6	0.5796	32
RPL5	Ribosomal protein L5	0.5754	32
RPL7A	Ribosomal protein L7a	0.5685	32
EIF2D	Eukaryotic translation initiation factor 2D	0.5673	32
CDCA7	Cell division cycle associated 7	0.5637	53
NOA1	Nitric oxide associated 1	0.5584	32
TOP1MT	DNA topoisomerase I mitochondrial	0.5571	32
MRPL45	Mitochondrial ribosomal protein L45	0.5548	32
RPL6	Ribosomal protein L6	0.5527	32
RPL10A	Ribosomal protein L10a	0.5472	32
CDK4	Cyclin dependent kinase 4	0.5394	39
RPL18	Ribosomal protein L18	0.5391	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	6.0 nTPM
Breast	6.8 nTPM
Adipose tissue	5.1 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	8.6 nTPM
Lung	8.6 nTPM

Astrocytes	1.3 nTPM
Brain	1.3 nTPM

B-cells	14.7 nTPM
Liver	24.3 nTPM
Kidney	19.0 nTPM
Bone marrow	18.8 nTPM
Spleen	17.6 nTPM
Adipose tissue	15.6 nTPM
Breast	14.7 nTPM
Stomach	11.3 nTPM
Lymph node	10.4 nTPM
PBMC	8.5 nTPM
Colon	6.4 nTPM

Dendritic cells	10.2 nTPM
PBMC	12.0 nTPM
Adipose tissue	9.5 nTPM
Breast	9.1 nTPM

Endothelial cells	9.0 nTPM
Placenta	14.2 nTPM
Prostate	13.2 nTPM
Skin	13.1 nTPM
Pancreas	11.6 nTPM
Liver	11.0 nTPM
Lung	9.3 nTPM
Testis	8.6 nTPM
Esophagus	8.2 nTPM
Breast	8.1 nTPM
Ovary	7.6 nTPM
Heart muscle	7.3 nTPM
Endometrium	7.3 nTPM
Skeletal muscle	4.4 nTPM
Eye	2.4 nTPM

Fibroblasts	15.4 nTPM
Placenta	25.0 nTPM
Ovary	23.5 nTPM
Heart muscle	20.7 nTPM
Prostate	18.4 nTPM
Lung	15.7 nTPM
Skin	15.2 nTPM
Breast	13.6 nTPM
Esophagus	10.3 nTPM
Skeletal muscle	9.8 nTPM
Adipose tissue	9.8 nTPM
Stomach	7.4 nTPM

Intestinal goblet cells	14.3 nTPM
Rectum	22.7 nTPM
Small intestine	11.7 nTPM
Colon	8.5 nTPM

Macrophages	16.2 nTPM
Ovary	30.7 nTPM
Kidney	24.9 nTPM
Testis	23.8 nTPM
Adipose tissue	21.8 nTPM
Bone marrow	18.8 nTPM
Endometrium	17.7 nTPM
Lung	15.0 nTPM
Skeletal muscle	13.7 nTPM
PBMC	13.6 nTPM
Spleen	13.5 nTPM
Breast	13.3 nTPM
Prostate	11.5 nTPM
Stomach	8.8 nTPM
Esophagus	7.9 nTPM
Pancreas	7.7 nTPM

Paneth cells	19.6 nTPM
Small intestine	30.0 nTPM
Rectum	28.7 nTPM
Colon	0.0 nTPM

Plasma cells	13.7 nTPM
Spleen	19.8 nTPM
Stomach	15.3 nTPM
Adipose tissue	14.2 nTPM
Bone marrow	13.2 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	5.8 nTPM
Bronchus	7.3 nTPM
Lung	4.4 nTPM

Smooth muscle cells	12.4 nTPM
Pancreas	22.9 nTPM
Prostate	21.6 nTPM
Endometrium	16.1 nTPM
Ovary	15.5 nTPM
Skin	14.3 nTPM
Esophagus	10.9 nTPM
Breast	9.6 nTPM
Adipose tissue	8.7 nTPM
Skeletal muscle	7.2 nTPM
Heart muscle	4.9 nTPM
Bronchus	4.7 nTPM

T-cells	11.2 nTPM
Colon	20.0 nTPM
Lung	16.7 nTPM
Kidney	15.8 nTPM
PBMC	15.2 nTPM
Skin	14.3 nTPM
Adipose tissue	12.0 nTPM
Stomach	11.0 nTPM
Liver	10.3 nTPM
Endometrium	10.0 nTPM
Breast	9.8 nTPM
Lymph node	9.7 nTPM
Prostate	9.5 nTPM
Bone marrow	8.3 nTPM
Spleen	8.2 nTPM
Skeletal muscle	8.0 nTPM
Esophagus	6.6 nTPM
Ovary	4.5 nTPM

Basal keratinocytes	20.6 nTPM
Skin	20.6 nTPM

Basal prostatic cells	27.7 nTPM
Prostate	27.7 nTPM

Basal respiratory cells	27.1 nTPM
Bronchus	27.1 nTPM

Basal squamous epithelial cells	27.9 nTPM
Esophagus	27.9 nTPM

Undifferentiated cells	24.1 nTPM
Rectum	29.6 nTPM
Small intestine	24.8 nTPM
Colon	17.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC